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Items: 1 to 20 of 207

1.
The translocation activity of Rad54 reduces crossover outcomes during homologous recombination
Krishay Sridalla, Mitchell V Woodhouse, Jingyi Hu, Jessica Scheer, Bryan Ferlez, J Brooks Crickard
Nucleic Acids Res. 2024 Jul 8; 52(12): 7031–7048. Published online 2024 Jun 3. doi: 10.1093/nar/gkae474
PMCID:
PMC11229335
AbstractArticlePDF–2.2M
2.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
3.
ATRX guards against aberrant differentiation in mesenchymal progenitor cells
Yan Fang, Douglas Barrows, Yakshi Dabas, Thomas S Carroll, Sam Singer, William D Tap, Benjamin A Nacev
Nucleic Acids Res. 2024 May 22; 52(9): 4950–4968. Published online 2024 Mar 13. doi: 10.1093/nar/gkae160
PMCID:
PMC11109985
AbstractArticlePDF–2.0M
4.
Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice
Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M. Flores, Simone Hausmann, Pawel K. Mazur
Sci Rep. 2024; 14: 8510. Published online 2024 Apr 12. doi: 10.1038/s41598-024-58874-2
PMCID:
PMC11014914
AbstractArticlePDF–1.7M
5.
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks
Lia M Pinto, Alexandros Pailas, Max Bondarchenko, Abhishek Bharadwaj Sharma, Katrin Neumann, Anthony J Rizzo, Céline Jeanty, Nathalie Nicot, Carine Racca, Mindy K Graham, Catherine Naughton, Yaqun Liu, Chun-Long Chen, Paul J Meakin, Nick Gilbert, Sébastien Britton, Alan K Meeker, Christopher M Heaphy, Florence Larminat, Eric Van Dyck
Nucleic Acids Res. 2024 Feb 9; 52(3): 1136–1155. Published online 2023 Dec 1. doi: 10.1093/nar/gkad1141
PMCID:
PMC10853780
AbstractArticlePDF–2.5M
6.
ATRX is a predictive marker for endocrinotherapy and chemotherapy resistance in HER2-/HR+ breast cancer through the regulation of the AR, GLI3 and GATA2 transcriptional network
Hongyan Qian, Rui Ji, Cheng Shen, Yinze Wei, Chenyi Sheng, Qichao Ni, Jing Pan, Yifan Chi, Huan You, Ying Miao, Minxin Shi, Xianghua Huang, Aiguo Shen
Aging (Albany NY) 2023 Dec 31; 15(24): 14996–15024. Published online 2023 Dec 20. doi: 10.18632/aging.205327
PMCID:
PMC10781474
AbstractArticlePDF–5.8M
7.
Mutant IDH1 Cooperates with ATRX Loss to Drive the Alternative Lengthening of Telomere Phenotype in Glioma
Joydeep Mukherjee, Tor-Christian Johannessen, Shigeo Ohba, Tracy T. Chow, Lindsey Jones, Ajay Pandita, Russell O. Pieper
Cancer Res. Author manuscript; available in PMC 2023 Oct 16.
Published in final edited form as: Cancer Res. 2018 Jun 1; 78(11): 2966–2977. Published online 2018 Mar 15. doi: 10.1158/0008-5472.CAN-17-2269
PMCID:
PMC10578296
AbstractArticlePDF–1.5M
8.
Inhibition of p53 and ATRX increases telomeric recombination in primary fibroblasts
Ion Udroiu, Jessica Marinaccio, Antonella Sgura
FEBS Open Bio. 2023 Sep; 13(9): 1683–1698. Published online 2023 Aug 3. doi: 10.1002/2211-5463.13680
PMCID:
PMC10476563
AbstractArticlePDF–2.0M
9.
Two opposing gene expression patterns within ATRX aberrant neuroblastoma
Michael R. van Gerven, Linda Schild, Jennemiek van Arkel, Bianca Koopmans, Luuk A. Broeils, Loes A. M. Meijs, Romy van Oosterhout, Max M. van Noesel, Jan Koster, Sander R. van Hooff, Jan J. Molenaar, Marlinde L. van den Boogaard
PLoS One. 2023; 18(8): e0289084. Published online 2023 Aug 4. doi: 10.1371/journal.pone.0289084
PMCID:
PMC10403137
AbstractArticlePDF–1.5M
10.
A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects
Rebekah Tillotson, Keqin Yan, Julie Ruston, Taylor DeYoung, Alex Córdova, Valérie Turcotte-Cardin, Yohan Yee, Christine Taylor, Shagana Visuvanathan, Christian Babbs, Evgueni A Ivakine, John G Sled, Brian J Nieman, David J Picketts, Monica J Justice
Hum Mol Genet. 2023 Aug 1; 32(15): 2485–2501. Published online 2023 May 12. doi: 10.1093/hmg/ddad075
PMCID:
PMC10360390
AbstractArticlePDF–1.7M
11.
Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants
Jennifer L Stundon, Heba Ijaz, Krutika S Gaonkar, Rebecca S Kaufman, Run Jin, Anastasios Karras, Zalman Vaksman, Jung Kim, Ryan J Corbett, Matthew R Lueder, Daniel P Miller, Yiran Guo, Mariarita Santi, Marilyn Li, Gonzalo Lopez, Phillip B Storm, Adam C Resnick, Angela J Waanders, Suzanne P MacFarland, Douglas R Stewart, Sharon J Diskin, Jo Lynne Rokita, Kristina A Cole
Neuro Oncol. 2023 Jul; 25(7): 1331–1342. Published online 2022 Dec 20. doi: 10.1093/neuonc/noac278
PMCID:
PMC10326481
AbstractArticlePDF–9.1M
12.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
13.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
14.
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions
Henri Bogumil, Martin Sill, Daniel Schrimpf, Britta Ismer, Christina Blume, Ramin Rahmanzade, Felix Hinz, Asan Cherkezov, Rouzbeh Banan, Dennis Friedel, David E. Reuss, Florian Selt, Jonas Ecker, Till Milde, Kristian W. Pajtler, Jens Schittenhelm, Jürgen Hench, Stephan Frank, Henning B. Boldt, Bjarne Winther Kristensen, David Scheie, Linea C. Melchior, Viola Olesen, Astrid Sehested, Daniel R. Boué, Zied Abdullaev, Laveniya Satgunaseelan, Ina Kurth, Annekatrin Seidlitz, Christine L. White, Ho-Keung Ng, Zhi-Feng Shi, Christine Haberler, Martina Deckert, Marco Timmer, Roland Goldbrunner, Arnault Tauziède-Espariat, Pascale Varlet, Sebastian Brandner, Sanda Alexandrescu, Matija Snuderl, Kenneth Aldape, Andrey Korshunov, Olaf Witt, Christel Herold-Mende, Andreas Unterberg, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David T. W. Jones, Felix Sahm, Philipp Sievers
Acta Neuropathol. 2023; 145(5): 667–680. Published online 2023 Mar 18. doi: 10.1007/s00401-023-02558-0
PMCID:
PMC10119244
AbstractArticlePDF–7.0M
15.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
16.
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188
PMCID:
PMC9881136
AbstractArticlePDF–4.4M
17.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
18.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
19.
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT
Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli
EMBO Mol Med. 2022 Oct; 14(10): e15859. Published online 2022 Aug 3. doi: 10.15252/emmm.202215859
PMCID:
PMC9549729
AbstractArticlePDF–15M
20.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M

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