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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104136522.

ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Mengshu Jia, Xiao Yue, Weixia Sun, Qianjun Zhou, Cheng Chang, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, Yejun Zou, Weicai Chen, Yan Li, Li Huang, Yi Yang, Yuzheng Zhao, Xiawei Cheng

Sci Adv. 2023 Jun 2; 9(22): eadg4993. Published online 2023 Jun 2. doi: 10.1126/sciadv.adg4993

PMCID:: PMC10413652

Abstract Article PDF–2.8M

Select item 103514363.

PIK3C3/VPS34 keeps body fats healthy

Wenqiang Song, J. Luke Postoak, Lan Wu, Luc Van Kaer

Autophagy. 2023; 19(8): 2398–2400. Published online 2023 Jan 18. doi: 10.1080/15548627.2023.2166275

PMCID:: PMC10351436

Abstract Article PDF–610K

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99732805.

Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34

Robert J. Cain, Mariela Scortti, Héctor J. Monzó, José A. Vázquez-Boland

mBio. 2023 Jan-Feb; 14(1): e03221-22. Published online 2023 Jan 19. doi: 10.1128/mbio.03221-22

PMCID:: PMC9973280

Abstract Article PDF–2.4M

Select item 94509856.

Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers

Shaoyang Zhang, Xiufeng Liu, Saleh Abdulmomen Ali Mohammed, Hui Li, Wanhua Cai, Wen Guan, Daiyun Liu, Yanli Wei, Dade Rong, Ying Fang, Farhan Haider, Haimei Lv, Ziwei Jin, Xiaomin Chen, Zhuomao Mo, Lujie Li, Shulan Yang, Haihe Wang

Autophagy. 2022; 18(8): 1822–1840. Published online 2021 Dec 6. doi: 10.1080/15548627.2021.2002108

PMCID:: PMC9450985

Abstract Article PDF–9.9M

Select item 94260357.

GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer

Feifei Zhou, Yufeng Liu, Wenqian Ai, Yanan Wang, Mingxi Gan, Qingkun Jiang, Tianyu Han, Jian-Bin Wang

Cell Commun Signal. 2022; 20: 133. Published online 2022 Aug 30. doi: 10.1186/s12964-022-00936-x

PMCID:: PMC9426035

Abstract Article PDF–3.0M

Select item 93434558.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 92885069.

Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein

Nat Commun. 2022; 13: 4146. Published online 2022 Jul 16. doi: 10.1038/s41467-022-31905-0

PMCID:: PMC9288506

Abstract Article PDF–3.9M

Select item 912461510.

Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss

Xiaobo Wang, Min Gu, Yongjian Ju, Juying Zhou

J Radiat Res. 2022 May; 63(3): 331–341. Published online 2022 Mar 25. doi: 10.1093/jrr/rrac004

PMCID:: PMC9124615

Abstract Article PDF–2.0M

Select item 911973611.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883612.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 872662413.

CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression

Xuan Li, Kai-Bin Yang, Wei Chen, Jia Mai, Xiao-Qi Wu, Ting Sun, Rui-Yan Wu, Lin Jiao, Dan-Dan Li, Jiao Ji, Hai-Liang Zhang, Yan Yu, Yu-Hong Chen, Gong-Kan Feng, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu

Autophagy. 2021; 17(12): 4323–4340. Published online 2021 May 12. doi: 10.1080/15548627.2021.1912270

PMCID:: PMC8726624

Abstract Article PDF–26M

Select item 854642014.

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

Mila Basic, Alexandra Hertel, Justyna Bajdzienko, Florian Bonn, Mariana Tellechea, Alexandra Stolz, Andreas Kern, Christian Behl, Anja Bremm

J Biol Chem. 2021 Nov; 297(5): 101263. Published online 2021 Sep 30. doi: 10.1016/j.jbc.2021.101263

PMCID:: PMC8546420

Abstract Article PDF–2.4M

Select item 849670615.

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3

Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou

Autophagy. 2021; 17(9): 2166–2183. Published online 2020 Sep 10. doi: 10.1080/15548627.2020.1817279

PMCID:: PMC8496706

Abstract Article PDF–10M

Select item 838661916.

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I

Cefan Zhou, Xuehong Qian, Miao Hu, Rui Zhang, Nanxi Liu, Yuan Huang, Jing Yang, Juan Zhang, Hua Bai, Yuyan Yang, Yefu Wang, Declan Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang

Autophagy. 2020; 16(10): 1786–1806. Published online 2019 Nov 7. doi: 10.1080/15548627.2019.1687212

PMCID:: PMC8386619

Abstract Article PDF–10M

Select item 838661517.

Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway

Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou

Autophagy. 2020; 16(9): 1697–1710. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704118

PMCID:: PMC8386615

Abstract Article PDF–3.6M

Select item 835328318.

ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication

Yafei Qu, Xin Wang, Yunkai Zhu, Weili Wang, Yuyan Wang, Gaowei Hu, Chengrong Liu, Jingjiao Li, Shanhui Ren, Maggie Z. X. Xiao, Zhenshan Liu, Chunxia Wang, Joyce Fu, Yucai Zhang, Ping Li, Rong Zhang, Qiming Liang

Front Cell Dev Biol. 2021; 9: 716208. Published online 2021 Jul 27. doi: 10.3389/fcell.2021.716208

PMCID:: PMC8353283

Abstract Article PDF–2.0M

Select item 835296419.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 828969520.

Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

Caroline G. Williams, Alexander S. Jureka, Jesus A. Silvas, Anthony M. Nicolini, Stacie A. Chvatal, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Christopher F. Basler

Cell Rep. 2021 Aug 3; 36(5): 109479. Published online 2021 Jul 20. doi: 10.1016/j.celrep.2021.109479

PMCID:: PMC8289695

Abstract Article PDF–4.1M

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