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Select item 99901471.

Structural basis of antifolate recognition and transport by PCFT

Joanne L. Parker, Justin C. Deme, Gabriel Kuteyi, Zhiyi Wu, Jiandong Huo, I. David Goldman, Raymond J. Owens, Philip C. Biggin, Susan M. Lea, Simon Newstead

Nature. Author manuscript; available in PMC 2023 Mar 7.

Published in final edited form as: Nature. 2021 Jul; 595(7865): 130–134. Published online 2021 May 26. doi: 10.1038/s41586-021-03579-z

PMCID:: PMC9990147

Abstract Article PDF–4.1M

Select item 95124842.

Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma

Dongyao Wang, Huiwen Wu, Jianxin Yang, Min Li, Changquan Ling, Zelong Gao, Hongtao Lu, Hui Shen, Yuxiao Tang

Hepatol Commun. 2022 Oct; 6(10): 2914–2924. Published online 2022 Jul 10. doi: 10.1002/hep4.2031

PMCID:: PMC9512484

Abstract Article PDF–10M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 79735454.

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H. Matherly, Zhanjun Hou

Sci Rep. 2021; 11: 6389. Published online 2021 Mar 18. doi: 10.1038/s41598-021-85818-x

PMCID:: PMC7973545

Abstract Article PDF–2.1M

Select item 76679815.

A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

He-Qin Zhan, Mitra Najmi, Kai Lin, Srinivas Aluri, Andras Fiser, I. David Goldman, Rongbao Zhao

J Biol Chem. 2020 Nov 13; 295(46): 15650–15661. Published online 2020 Sep 6. doi: 10.1074/jbc.RA120.014757

PMCID:: PMC7667981

Abstract Article PDF–2.3M

Select item 74348956.

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

Giovanna Li Petri, Btissame El Hassouni, Rocco Sciarrillo, Niccola Funel, Giulia Mantini, Eveline A. Zeeuw van der Laan, Stella Cascioferro, Amir Avan, Paolo Andrea Zucali, Nadia Zaffaroni, Tonny Lagerweij, Barbara Parrino, Kees Smid, Marcello Deraco, Carlotta Granchi, Alicja Braczko, Ryszard T. Smolenski, Larry H. Matherly, Gerrit Jansen, Yehuda G. Assaraf, Patrizia Diana, Jacqueline Cloos, Godefridus J. Peters, Filippo Minutolo, Elisa Giovannetti

Br J Cancer. 2020 Aug 18; 123(4): 644–656. Published online 2020 Jun 4. doi: 10.1038/s41416-020-0912-9

PMCID:: PMC7434895

Abstract Article PDF–1.2M

Select item 70501037.

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair

Zhen Chen, Chao Wang, Antrix Jain, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Xu Feng, Litong Nie, Dan Su, Yun Xiong, Sung Yun Jung, Jun Qin, Junjie Chen

Mol Cell Proteomics. 2020 Mar; 19(3): 467–477. Published online 2020 Jan 3. doi: 10.1074/mcp.RA119.001794

PMCID:: PMC7050103

Abstract Article PDF–1.8M

Select item 67941958.

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1

Zhanjun Hou, Carrie O’Connor, Josephine Frühauf, Steve Orr, Seongho Kim, Aleem Gangjee, Larry H. Matherly

Biochem J. Author manuscript; available in PMC 2019 Oct 15.

Published in final edited form as: Biochem J. 2019 Apr 26; 476(8): 1247–1266. Published online 2019 Apr 26. doi: 10.1042/BCJ20180394

PMCID:: PMC6794195

Abstract Article PDF–1.8M

Select item 65095039.

Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation

Srinivas Aluri, Rongbao Zhao, Kai Lin, Daniel Sanghoon Shin, Andras Fiser, I. David Goldman

J Biol Chem. 2019 May 3; 294(18): 7245–7258. Published online 2019 Mar 11. doi: 10.1074/jbc.RA118.005533

PMCID:: PMC6509503

Abstract Article PDF–2.4M

Select item 641565210.

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)

Srinivas Aluri, Rongbao Zhao, Andras Fiser, I. David Goldman

Am J Physiol Cell Physiol. 2018 Mar 1; 314(3): C289–C296. Published online 2017 Nov 22. doi: 10.1152/ajpcell.00215.2017

PMCID:: PMC6415652

Abstract Article

Select item 620529011.

Evaluation of Proton-Coupled Folate Transporter (SLC46A1) Polymorphisms as Risk Factors for Neural Tube Defects and Oral Clefts

Julia E. VanderMeer, Tonia C. Carter, Faith Pangilinan, Adam Mitchell, Emma Kurnat-Thoma, Peadar N. Kirke, James F. Troendle, Anne M. Molloy, Ronald G. Munger, Marcia L. Feldkamp, Maria A. Mansilla, James L. Mills, Jeff C. Murray, Lawrence C. Brody

Am J Med Genet A. Author manuscript; available in PMC 2018 Oct 29.

Published in final edited form as: Am J Med Genet A. 2016 Apr; 170A(4): 1007–1016. Published online 2016 Jan 20. doi: 10.1002/ajmg.a.37539

PMCID:: PMC6205290

Abstract Article PDF–416K

Select item 580866812.

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools

E Giovannetti, P A Zucali, Y G Assaraf, N Funel, M Gemelli, M Stark, E Thunnissen, Z Hou, I B Muller, E A Struys, M Perrino, G Jansen, L H Matherly, G J Peters

Ann Oncol. 2017 Nov; 28(11): 2725–2732. Published online 2017 Sep 7. doi: 10.1093/annonc/mdx499

PMCID:: PMC5808668

Abstract Article PDF–745K

Select item 576162813.

Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1

Srinivas Aluri, Rongbao Zhao, Charlotte Lubout, Susanna M. I. Goorden, Andras Fiser, I. David Goldman

Blood Adv. 2018 Jan 9; 2(1): 61–68. Published online 2018 Jan 5. doi: 10.1182/bloodadvances.2017012690

PMCID:: PMC5761628

Abstract Article PDF–1.2M

Select item 562432514.

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

Srinivas Aluri, Rongbao Zhao, Andras Fiser, I David Goldman

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Nov; 1859(11): 2193–2202. Published online 2017 Aug 9. doi: 10.1016/j.bbamem.2017.08.006

PMCID:: PMC5624325

Abstract Article PDF–834K

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 544335116.

Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates

Zhanjun Hou, Leda Gattoc, Carrie O’Connor, Si Yang, Adrianne Wallace-Povirk, Christina George, Steve Orr, Lisa Polin, Kathryn White, Juiwanna Kushner, Robert T. Morris, Aleem Gangjee, Larry H. Matherly

Mol Cancer Ther. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Mol Cancer Ther. 2017 May; 16(5): 819–830. Published online 2017 Jan 30. doi: 10.1158/1535-7163.MCT-16-0444