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Select item 110657491.

RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms

Ilin V. Joshi, Eunice C. Chan, Justin B. Lack, Chengyu Liu, Kirk M. Druey

J Biol Chem. 2024 Apr; 300(4): 107127. Published online 2024 Mar 2. doi: 10.1016/j.jbc.2024.107127

PMCID:: PMC11065749

Abstract Article PDF–3.9M

Select item 101470952.

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4

Jordana I. Borges, Malka S. Suster, Anastasios Lymperopoulos

Int J Mol Sci. 2023 Apr; 24(7): 6136. Published online 2023 Mar 24. doi: 10.3390/ijms24076136

PMCID:: PMC10147095

Abstract Article PDF–1.0M

Select item 91472833.

Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling

Alexandra M. Carbone, Jordana I. Borges, Malka S. Suster, Anastasiya Sizova, Natalie Cora, Victoria L. Desimine, Anastasios Lymperopoulos

Int J Mol Sci. 2022 May; 23(10): 5803. Published online 2022 May 22. doi: 10.3390/ijms23105803

PMCID:: PMC9147283

Abstract Article PDF–1.3M

Select item 86856714.

The N-terminal cysteine is a dual sensor of oxygen and oxidative stress

Ah Jung Heo, Su Bin Kim, Chang Hoon Ji, Dohyun Han, Su Jin Lee, Su Hyun Lee, Min Ju Lee, Ji Su Lee, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon

Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2107993118. Published online 2021 Dec 10. doi: 10.1073/pnas.2107993118

PMCID:: PMC8685671

Abstract Article PDF–3.1M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75011786.

RGS4 promotes allergen- and aspirin-associated airway hyper-responsiveness by inhibiting PGE2 biosynthesis

Gordon S. Wong, Jamie L. Redes, Nariman Balenga, Morgan McCullough, Nathalie Fuentes, Ameya Gokhale, Cynthia Koziol-White, Joseph A. Jude, Laura A. Madigan, Eunice C. Chan, William H. Jester, Sabrina Biardel, Nicolas Flamand, Reynold A. Panettieri, Jr., Kirk M. Druey

J Allergy Clin Immunol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Allergy Clin Immunol. 2020 Nov; 146(5): 1152–1164.e13. Published online 2020 Mar 19. doi: 10.1016/j.jaci.2020.03.004

PMCID:: PMC7501178

Abstract Article PDF–2.6M

Select item 75008057.

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Hoau-Yan Wang, Mathew L. MacDonald, Karin E. Borgmann-Winter, Anamika Banerjee, Patrick Sleiman, Andrew Tom, Amber Khan, Kuo-Chieh Lee, Panos Roussos, Steven J. Siegel, Scott E Hemby, Warren B. Bilker, Raquel E. Gur, Chang-Gyu Hahn

Mol Psychiatry. Author manuscript; available in PMC 2020 Sep 18.

Published in final edited form as: Mol Psychiatry. 2020 Apr; 25(4): 750–760. Published online 2018 Sep 13. doi: 10.1038/s41380-018-0234-y

PMCID:: PMC7500805

Abstract Article PDF–1.2M

Select item 72854728.

Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells

Yukeyoung Kim, Sungho Ghil

Cell Commun Signal. 2020; 18: 86. Published online 2020 Jun 9. doi: 10.1186/s12964-020-00552-7

PMCID:: PMC7285472

Abstract Article PDF–2.4M

Select item 72475889.

Targeting RGS4 Ablates Glioblastoma Proliferation

Maheedhara R. Guda, Kiran K. Velpula, Swapna Asuthkar, Charlie P. Cain, Andrew J. Tsung

Int J Mol Sci. 2020 May; 21(9): 3300. Published online 2020 May 7. doi: 10.3390/ijms21093300

PMCID:: PMC7247588

Abstract Article PDF–3.8M

Select item 667375210.

Allelic Variation in RGS4 Impacts Functional and Structural Connectivity in the Human Brain

Joshua W. Buckholtz, Andreas Meyer-Lindenberg, Robyn A. Honea, Richard E. Straub, Lukas Pezawas, Michael F. Egan, Radhakrishna Vakkalanka, Bhaskar Kolachana, Beth A. Verchinski, Steven Sust, Venkata S. Mattay, Daniel R. Weinberger, Joseph H. Callicott

J Neurosci. 2007 Feb 14; 27(7): 1584–1593. doi: 10.1523/JNEUROSCI.5112-06.2007

PMCID:: PMC6673752

Abstract Article PDF–291K

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 514695412.

Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gα_i/o

Jae-Pyo Jeon, Dhananjay P. Thakur, Jin-bin Tian, Insuk So, Michael X. Zhu

Biochem J. Author manuscript; available in PMC 2017 May 15.

Published in final edited form as: Biochem J. 2016 May 15; 473(10): 1379–1390. Published online 2016 Mar 17. doi: 10.1042/BCJ20160214

PMCID:: PMC5146954

Abstract Article PDF–1.0M

Select item 503481713.

Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP‐dependent manner

Rema Santhappan, Alicia Tamara Crowder, Shawn Gouty, Brian M. Cox, Thomas E. Côté

J Neurochem. 2015 Oct; 135(1): 76–87. Published online 2015 Jul 16. doi: 10.1111/jnc.13222

PMCID:: PMC5034817

Abstract Article PDF–965K

Select item 452104414.

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling

Aaisha Opel, Muriel Nobles, David Montaigne, Malcolm Finlay, Naomi Anderson, Ross Breckenridge, Andrew Tinker

J Biol Chem. 2015 Jul 31; 290(31): 19233–19244. Published online 2015 Jun 18. doi: 10.1074/jbc.M115.666719

PMCID:: PMC4521044

Abstract Article PDF–2.0M

Select item 389433815.

Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins

Buxin Chen, David P. Siderovski, Richard R. Neubig, Mark A. Lawson, JoAnn Trejo

J Biol Chem. 2014 Jan 17; 289(3): 1580–1591. Published online 2013 Dec 2. doi: 10.1074/jbc.M113.528273

PMCID:: PMC3894338

Abstract Article PDF–2.4M

Select item 378792216.

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

Linda M. Brzustowicz, Kathleen A. Hodgkinson, Eva W. C. Chow, William G. Honer, Anne S. Bassett

Science. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Science. 2000 Apr 28; 288(5466): 678–682. doi: 10.1126/science.288.5466.678

PMCID:: PMC3787922

Abstract Article PDF–600K

Select item 375729717.

Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system

Jing Jiang, Brooke L. Fridley, Qiping Feng, Ryan P. Abo, Abra Brisbin, Anthony Batzler, Gregory Jenkins, Pamela A. Long, Liewei Wang

Front Genet. 2013; 4: 166. Published online 2013 Aug 30. doi: 10.3389/fgene.2013.00166

PMCID:: PMC3757297

Abstract Article PDF–2.6M

Select item 372464018.

Rab Family Proteins Regulate the Endosomal Trafficking and Function of RGS4

Guillaume Bastin, Scott P. Heximer

J Biol Chem. 2013 Jul 26; 288(30): 21836–21849. Published online 2013 Jun 3. doi: 10.1074/jbc.M113.466888

PMCID:: PMC3724640

Abstract Article PDF–2.9M

Select item 365782019.

Regulator of G protein signaling 4 is a crucial modulator of antidepressant drug action in depression and neuropathic pain models

Maria Stratinaki, Artemis Varidaki, Vasiliki Mitsi, Subroto Ghose, Jane Magida, Caroline Dias, Scott J. Russo, Vincent Vialou, Barbara J. Caldarone, Carol A. Tamminga, Eric J. Nestler, Venetia Zachariou

Proc Natl Acad Sci U S A. 2013 May 14; 110(20): 8254–8259. Published online 2013 Apr 29. doi: 10.1073/pnas.1214696110