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Select item 110114001.

Squalene Epoxidase: Its Regulations and Links with Cancers

Lin Zhang, Zheng Cao, Yuheng Hong, Haihua He, Leifeng Chen, Zhentao Yu, Yibo Gao

Int J Mol Sci. 2024 Apr; 25(7): 3874. Published online 2024 Mar 30. doi: 10.3390/ijms25073874

PMCID:: PMC11011400

Abstract Article PDF–3.7M

Select item 108757112.

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index

Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang

Clin Transl Med. 2024 Feb; 14(2): e1586. Published online 2024 Feb 19. doi: 10.1002/ctm2.1586

PMCID:: PMC10875711

Abstract Article PDF–20M

Select item 107768543.

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE

J. Josephine Botsch, Roswitha Junker, Michèle Sorgenfrei, Patricia P. Ogger, Luca Stier, Susanne von Gronau, Peter J. Murray, Markus A. Seeger, Brenda A. Schulman, Bastian Bräuning

Nat Commun. 2024; 15: 410. Published online 2024 Jan 9. doi: 10.1038/s41467-023-44670-5

PMCID:: PMC10776854

Abstract Article PDF–6.1M

Select item 104035824.

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway

Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao

Cell Death Dis. 2023 Aug; 14(8): 497. Published online 2023 Aug 4. doi: 10.1038/s41419-023-05987-7

PMCID:: PMC10403582

Abstract Article PDF–8.1M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101762586.

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown

J Lipid Res. 2023 May; 64(5): 100362. Published online 2023 Mar 22. doi: 10.1016/j.jlr.2023.100362

PMCID:: PMC10176258

Abstract Article PDF–2.2M

Select item 96273667.

Downregulated ferroptosis‐related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma

Lei Yao, Juanni Li, Xiaofang Zhang, Lei Zhou, Kuan Hu

CNS Neurosci Ther. 2022 Dec; 28(12): 2104–2115. Published online 2022 Aug 13. doi: 10.1111/cns.13945

PMCID:: PMC9627366

Abstract Article PDF–14M

Select item 95236458.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 92587149.

SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis

Shuhui Wang, Lei Dong, Lin Ma, Suzhen Yang, Ying Zheng, Jing Zhang, Chuanghong Wu, Yidi Zhao, Yangfan Hou, Hong Li, Ting Wang

J Cell Mol Med. 2022 Jul; 26(13): 3636–3647. Published online 2022 May 31. doi: 10.1111/jcmm.17347

PMCID:: PMC9258714

Abstract Article PDF–5.3M

Select item 920431910.

SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma

Weiqiang You, Jia Ke, Yufeng Chen, Zerong Cai, Ze-ping Huang, Peishan Hu, Xiaojian Wu

Front Immunol. 2022; 13: 864244. Published online 2022 May 26. doi: 10.3389/fimmu.2022.864244

PMCID:: PMC9204319

Abstract Article PDF–11M

Select item 911973611.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 889870412.

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression

Huihong Jiang, Erjiang Tang, Ying Chen, Hailong Liu, Yun Zhao, Moubin Lin, Luwei He

Cancer Sci. 2022 Mar; 113(3): 971–985. Published online 2022 Jan 6. doi: 10.1111/cas.15248

PMCID:: PMC8898704

Abstract Article PDF–2.6M

Select item 855520913.

Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer

Wenqing Tang, Fangshi Xu, Meng Zhao, Shuqun Zhang

BMC Cancer. 2021; 21: 1160. Published online 2021 Oct 29. doi: 10.1186/s12885-021-08892-4

PMCID:: PMC8555209

Abstract Article PDF–6.1M

Select item 837921414.

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze

Nat Commun. 2021; 12: 5066. Published online 2021 Aug 20. doi: 10.1038/s41467-021-25325-9

PMCID:: PMC8379214

Abstract Article PDF–3.0M

Select item 836064115.

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Luwei He, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao, Moubin Lin

Cancer Commun (Lond) 2021 Aug; 41(8): 726–746. Published online 2021 Jul 16. doi: 10.1002/cac2.12187

PMCID:: PMC8360641

Abstract Article PDF–4.4M

Select item 816677516.

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

Hudson W. Coates, Isabelle M. Capell-Hattam, Andrew J. Brown

J Biol Chem. 2021 Jan-Jun; 296: 100731. Published online 2021 Apr 30. doi: 10.1016/j.jbc.2021.100731

PMCID:: PMC8166775

Abstract Article PDF–3.5M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 799307618.

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane, Zhe Han

Cell Biosci. 2021; 11: 58. Published online 2021 Mar 25. doi: 10.1186/s13578-021-00568-7

PMCID:: PMC7993076

Abstract Article PDF–2.0M

Select item 756688119.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 739233420.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

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