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Select item 111865771.

The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating Corneal Epithelial Wound Healing

Xuemei Ling, Weiwei Xu, Jingjing Tang, Qiongjie Cao, Guangying Luo, Xiaoyan Chen, Shuai Yang, Peter Sol Reinach, Dongsheng Yan

Invest Ophthalmol Vis Sci. 2024 Jun; 65(6): 29. Published online 2024 Jun 18. doi: 10.1167/iovs.65.6.29

PMCID:: PMC11186577

Abstract Article PDF–9.4M

Select item 111510502.

Thrombospondin‐1 Regulates Trophoblast Necroptosis via NEDD4‐Mediated Ubiquitination of TAK1 in Preeclampsia

Haoyue Hu, Jing Ma, You Peng, Rixuan Feng, Chenling Luo, Minyi Zhang, Zixin Tao, Lu Chen, Tao Zhang, Wenqian Chen, Qian Yin, Jinguo Zhai, Jun Chen, Ailan Yin, Chi Chiu Wang, Mei Zhong

Adv Sci (Weinh) 2024 Jun; 11(21): 2309002. Published online 2024 Apr 3. doi: 10.1002/advs.202309002

PMCID:: PMC11151050

Abstract Article PDF–15M

Select item 111181083.

ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis

Jiancheng He, Jianfeng Yi, Li Ji, Lingchen Dai, Yu Chen, Wanjiang Xue

Mol Med. 2024; 30: 69. Published online 2024 May 23. doi: 10.1186/s10020-024-00832-9

PMCID:: PMC11118108

Abstract Article PDF–3.6M

Select item 110246844.

DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage

Bingchen Lv, Ping Fu, Miao Wang, Likun Cui, Lei Bao, Xingzhi Wang, Lu Yu, Chao Zhou, Mengxin Zhu, Fei Wang, Ye Pang, Suhua Qi, Zuohui Zhang, Guiyun Cui

CNS Neurosci Ther. 2024 Apr; 30(4): e14685. Published online 2024 Apr 18. doi: 10.1111/cns.14685

PMCID:: PMC11024684

Abstract Article PDF–20M

Select item 109457075.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 108263276.

Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation

Zhiyi Liu, Qinghe Hu, Bin Hu, Kuan Cao, Tao Xu, Tianqi Hou, Tong Cao, Renhao Wang, Hengliang Shi, Bin Zhang

J Biol Chem. 2024 Jan; 300(1): 105593. Published online 2023 Dec 23. doi: 10.1016/j.jbc.2023.105593

PMCID:: PMC10826327

Abstract Article PDF–4.7M

Select item 107826157.

PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer

Liang Xu, Wanying Xiang, Jiezhen Yang, Jing Gao, Xinyue Wang, Li Meng, Kaihong Ye, Xiao Hong Zhao, Xu Dong Zhang, Lei Jin, Yan Ye

J Exp Clin Cancer Res. 2024; 43: 17. Published online 2024 Jan 11. doi: 10.1186/s13046-023-02937-1

PMCID:: PMC10782615

Abstract Article PDF–3.4M

Select item 105892728.

Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding

George Kefalas, Daniela Rotin

Sci Rep. 2023; 13: 17903. Published online 2023 Oct 20. doi: 10.1038/s41598-023-44761-9

PMCID:: PMC10589272

Abstract Article PDF–1.9M

Select item 103338849.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017409111.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 1013280512.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Filip Mihalič, Leandro Simonetti, Girolamo Giudice, Marie Rubin Sander, Richard Lindqvist, Marie Berit Akpiroro Peters, Caroline Benz, Eszter Kassa, Dilip Badgujar, Raviteja Inturi, Muhammad Ali, Izabella Krystkowiak, Ahmed Sayadi, Eva Andersson, Hanna Aronsson, Ola Söderberg, Doreen Dobritzsch, Evangelia Petsalaki, Anna K. Överby, Per Jemth, Norman E. Davey, Ylva Ivarsson

Nat Commun. 2023; 14: 2409. Published online 2023 Apr 26. doi: 10.1038/s41467-023-38015-5

PMCID:: PMC10132805

Abstract Article PDF–4.2M

Select item 1007150013.

A Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination

Reina Iwase, Daniel R. Dempsey, Samuel D. Whedon, Hanjie Jiang, Brad A. Palanski, Bedphiny Deng, Philip A. Cole

J Am Chem Soc. Author manuscript; available in PMC 2024 Mar 22.

Published in final edited form as: J Am Chem Soc. 2023 Mar 22; 145(11): 6039–6044. Published online 2023 Mar 10. doi: 10.1021/jacs.2c13871

PMCID:: PMC10071500

Abstract Article PDF–1.2M

Select item 1000869014.

Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer

Chenxi Zhong, Guosheng Xiong, Haitang Yang, Xiaohua Du, Jiankui Du, Feng Yao, Wentao Fang, Yuezhen Deng

Int J Biol Sci. 2023; 19(4): 1110–1122. Published online 2023 Feb 5. doi: 10.7150/ijbs.82015

PMCID:: PMC10008690

Abstract Article PDF–6.9M

Select item 994498415.

HECT domain interaction with ubiquitin binding sites on Tsg101-UEV controls HIV-1 egress, maturation, and infectivity

David A. Nyenhuis, Rohith Rajasekaran, Susan Watanabe, Marie-Paule Strub, Mahfuz Khan, Michael Powell, Carol A. Carter, Nico Tjandra

J Biol Chem. 2023 Feb; 299(2): 102901. Published online 2023 Jan 13. doi: 10.1016/j.jbc.2023.102901

PMCID:: PMC9944984

Abstract Article PDF–2.0M

Select item 989669716.

NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis

Wenjing Sun, Hongquan Lu, Shihua Cui, Shenghui Zhao, Haijia Yu, Huihui song, Qiuyue Ruan, Yabin Zhang, Yingjie Chu, Shujuan Dong

Cell Commun Signal. 2023; 21: 29. Published online 2023 Feb 2. doi: 10.1186/s12964-022-01022-y

PMCID:: PMC9896697

Abstract Article PDF–11M

Select item 960416917.

Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer

Sujitha Jayaprakash, Mangala Hegde, Bandari BharathwajChetty, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara

Int J Mol Sci. 2022 Oct; 23(20): 12380. Published online 2022 Oct 16. doi: 10.3390/ijms232012380

PMCID:: PMC9604169

Abstract Article PDF–2.7M

Select item 948193318.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 928970919.

TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

Yi Yang, Yifu Zhu, Shuai Zhou, Peipei Tang, Ran Xu, Yuwei Zhang, Dongping Wei, Jian Wen, Rick F Thorne, Xu Dong Zhang, Jun‐Lin Guan, Lianxin Liu, Mian Wu, Song Chen

EMBO J. 2022 Jul; 41(14): e109777. Published online 2022 Jun 7. doi: 10.15252/embj.2021109777