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Select item 109332671.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 107960872.

G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease

Aina Bellver-Sanchis, Qizhi Geng, Gemma Navarro, Pedro A. Ávila-López, Júlia Companys-Alemany, Laura Marsal-García, Raquel Larramona-Arcas, Lluisa Miró, Anna Perez-Bosque, Daniel Ortuño-Sahagún, Deb Ranjan Banerjee, Bhanwar Singh Choudhary, Francesc X Soriano, Coralie Poulard, Mercè Pallàs, Hai-Ning Du, Christian Griñán-Ferré

Aging Dis. 2024 Feb 1; 15(1): 311–337. Published online 2024 Feb 1. doi: 10.14336/AD.2023.0424-2

PMCID:: PMC10796087

Abstract Article PDF–1.5M

Select item 106076323.

Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma

Barbara Kunzler Souza, Natalia Hogetop Freire, Thiago Santos Monteiro, Alice Laschuk Herlinger, Mariane Jaeger, Matheus G. S. Dalmolin, Caroline Brunetto de Farias, Lauro Gregianin, André T. Brunetto, Algemir L. Brunetto, Carol J. Thiele, Rafael Roesler

Int J Mol Sci. 2023 Oct; 24(20): 15242. Published online 2023 Oct 17. doi: 10.3390/ijms242015242

PMCID:: PMC10607632

Abstract Article PDF–2.6M

Select item 105171714.

Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte

Zhiqin Fang, Yutong Wang, Bo Huang, Xiang Chen, Rundong Jiang, Mingzhu Yin

Cell Death Dis. 2023 Sep; 14(9): 627. Published online 2023 Sep 22. doi: 10.1038/s41419-023-06134-y

PMCID:: PMC10517171

Abstract Article PDF–9.7M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 97696986.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 95403457.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 94396818.

EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS ^G12D tumor development and propagation

Ariel Pribluda, Anneleen Daemen, Anthony Nelson Lima, Xi Wang, Marc Hafner, Chungkee Poon, Zora Modrusan, Anand Kumar Katakam, Oded Foreman, Jefferey Eastham, Jefferey Hung, Benjamin Haley, Julia T Garcia, Erica L Jackson, Melissa R Junttila

eLife. 2022; 11: e57648. Published online 2022 Aug 19. doi: 10.7554/eLife.57648

PMCID:: PMC9439681

Abstract Article PDF–3.9M

Select item 94339389.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 935700310.

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang

Nat Commun. 2022; 13: 4601. Published online 2022 Aug 6. doi: 10.1038/s41467-022-32295-z

PMCID:: PMC9357003

Abstract Article PDF–3.7M

Select item 934857611.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 933831312.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 929024113.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 927928514.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 925731815.

EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression

Jun Wang, Hui Xu, Shuang Ge, Chaoshuai Xue, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Cuijuan Zhang

Cancer Biol Med. 2022 Jun 15; 19(6): 836–849. Published online 2021 Oct 12. doi: 10.20892/j.issn.2095-3941.2020.0371

PMCID:: PMC9257318

Abstract Article PDF–1.6M

Select item 911973616.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523517.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 903876618.

Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer

Tae Young Ryu, Kwangho Kim, Tae-Su Han, Mi-Ok Lee, Jinkwon Lee, Jinhyeon Choi, Kwang Bo Jung, Eun-Jeong Jeong, Da Mi An, Cho-Rok Jung, Jung Hwa Lim, Jaeeun Jung, Kunhyang Park, Moo-Seung Lee, Mi-Young Kim, Soo Jin Oh, Keun Hur, Ryuji Hamamoto, Doo-Sang Park, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho

ISME J. 2022 May; 16(5): 1205–1221. Published online 2022 Jan 1. doi: 10.1038/s41396-021-01119-1

PMCID:: PMC9038766

Abstract Article PDF–7.1M

Select item 892305719.

Transcription Factor Protein Interactomes Reveal Genetic Determinants in Heart Disease

Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E. J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J. G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Cell. Author manuscript; available in PMC 2023 Mar 3.

Published in final edited form as: Cell. 2022 Mar 3; 185(5): 794–814.e30. Published online 2022 Feb 18. doi: 10.1016/j.cell.2022.01.021

PMCID:: PMC8923057

Abstract Article PDF–2.5M

Select item 882889520.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

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