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Select item 112190421.

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho

eLife. 2024; 13: e71980. Published online 2024 May 23. doi: 10.7554/eLife.71980

PMCID:: PMC11219042

Abstract Article PDF–2.0M

Select item 111926322.

miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression

Chen Wang, Runxi Fu, Yunkun Wang, Jia Wei, Ying Yu, Liuhua Hu, Chenran Zhang

Cancer Gene Ther. 2024; 31(6): 941–954. Published online 2024 Mar 19. doi: 10.1038/s41417-024-00762-y

PMCID:: PMC11192632

Abstract Article PDF–5.5M

Select item 111581823.

Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

Kazuhito Morioka, Chizu Tanikawa, Kensuke Ochi, Yataro Daigo, Toyomasa Katagiri, Hirotaka Kawano, Hiroshi Kawaguchi, Akira Myoui, Hideki Yoshikawa, Norifumi Naka, Nobuto Araki, Ikuo Kudawara, Makoto Ieguchi, Kozo Nakamura, Yusuke Nakamura, Koichi Matsuda

Cancer Sci. 2009 Jul; 100(7): 1227–1233. Published online 2009 Mar 25. doi: 10.1111/j.1349-7006.2009.01165.x

PMCID:: PMC11158182

Abstract Article PDF–815K

Select item 111135054.

Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

Lili Li, Jianming Ying, Xin Tong, Lan Zhong, Xianwei Su, Tingxiu Xiang, Xingsheng Shu, Rong Rong, Lei Xiong, Hongyu Li, Anthony T. C. Chan, Richard F. Ambinder, Yajun Guo, Qian Tao

Cell Mol Life Sci. 2014 Jun; 71(11): 2179–2192. Published online 2013 Oct 25. doi: 10.1007/s00018-013-1485-z

PMCID:: PMC11113505

Abstract Article PDF–4.5M

Select item 107714385.

ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons

Takuya Kuroda, Satoshi Yasuda, Satoko Matsuyama, Takumi Miura, Rumi Sawada, Akifumi Matsuyama, Yumiko Yamamoto, Masaki Suimye Morioka, Hideya Kawaji, Takeya Kasukawa, Masayoshi Itoh, Hidenori Akutsu, Jun Kawai, Yoji Sato

Sci Rep. 2024; 14: 690. Published online 2024 Jan 6. doi: 10.1038/s41598-023-51082-4

PMCID:: PMC10771438

Abstract Article PDF–1.7M

Select item 106958706.

Expression of Wnt5a and ROR2, Components of the Noncanonical Wnt-Signaling Pathway, is Associated with Tumor Differentiation in Hepatocellular Carcinoma

Kazuki Wakizaka, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Akihisa Nagatsu, Takeshi Aiyama, Shunsuke Shichi, Akinobu Taketomi

Ann Surg Oncol. 2024; 31(1): 262–271. Published online 2023 Oct 9. doi: 10.1245/s10434-023-14402-6

PMCID:: PMC10695870

Abstract Article PDF–899K

Select item 106606437.

ROR2 deficit may induce the tetralogy of Fallot via down‐regulating of β‐catenin/SOX3/HSPA6 in vitro and in vivo

Rui Guo, Yiran Zhou Guo, Qing Zhou, Guoju Li, Zhanghui Du, Yefei Shi, Quansheng Xing

J Cell Mol Med. 2023 Nov; 27(22): 3539–3552. Published online 2023 Sep 25. doi: 10.1111/jcmm.17969

PMCID:: PMC10660643

Abstract Article PDF–11M

Select item 106415248.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 105658769.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1052346110.

Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2

Sally Rogers, Chengting Zhang, Vasilis Anagnostidis, Corin Liddle, Melissa L. Fishel, Fabrice Gielen, Steffen Scholpp

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2217612120. Published online 2023 Sep 18. doi: 10.1073/pnas.2217612120

PMCID:: PMC10523461

Abstract Article PDF–3.5M

Select item 1013218111.

Downregulation of ROR2 attenuates LPS‐induced A549 cell injury through JNK and ERK signaling pathways

Zhonglin Wang, Liu Yang

Immun Inflamm Dis. 2023 Apr; 11(4): e803. Published online 2023 Apr 26. doi: 10.1002/iid3.803

PMCID:: PMC10132181

Abstract Article PDF–1.8M

Select item 1006029212.

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma

Nicholas Coupe, Lina Guo, Esther Bridges, Leticia Campo, Olivia Espinosa, Richard Colling, Andrea Marshall, Ashwin Nandakumar, Ruud van Stiphout, Francesca M. Buffa, Pippa G. Corrie, Mark R. Middleton, Valentine M. Macaulay

Cell Oncol (Dordr) 2023; 46(2): 391–407. Published online 2022 Dec 21. doi: 10.1007/s13402-022-00757-7

PMCID:: PMC10060292

Abstract Article PDF–2.2M

Select item 958280013.

Noncanonical Wnt/Ror2 signaling regulates cell–matrix adhesion to prompt directional tumor cell invasion in breast cancer

Hongjiang Si, Na Zhao, Andrea Pedroza, Ana-Maria Zaske, Jeffrey M. Rosen, Chad J. Creighton, Kevin Roarty

Mol Biol Cell. 2022 Sep 15; 33(11): ar103. Published online 2022 Sep 7. doi: 10.1091/mbc.E22-02-0055

PMCID:: PMC9582800

Abstract Article PDF–13M

Select item 923162314.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 917763615.

Phenotypic and mutational spectrum of ROR2-related Robinow syndrome

Ariadne R. Lima, Barbara M. Ferreira, Chaofan Zhang, Angad Jolly, Haowei Du, Janson J. White, Moez Dawood, Tulio C. Lins, Marcela A. Chiabai, Ellen van Beusekom, Mara S. Cordoba, Erica C.C. Caldas Rosa, Hulya Kayserili, Virginia Kimonis, Erica Wu, Cecilia Mellado, Vineet Aggarwal, Antonio Richieri-Costa, Décio Brunoni, Talyta M. Canó, Alexander A. L. Jorge, Chong A. Kim, Rachel Honjo, Débora R. Bertola, Raissa M. Dandalo-Girardi, Yavuz Bayram, Alper Gezdirici, Elif Yilmaz-Gulec, Evren Gumus, Gülay C. Yilmaz, Nobuhiko Okamoto, Hirofumi Ohashi, Zeynep Coban–Akdemir, Tadahiro Mitani, Shalini N. Jhangiani, Donna M. Muzny, Neysa A.P. Regattieri, Robert Pogue, Rinaldo W. Pereira, Paulo A. Otto, Richard A. Gibbs, Bassam R. Ali, Hans van Bokhoven, Han G. Brunner, V. Reid Sutton, James R. Lupski, Angela M. Vianna-Morgante, Claudia M. B. Carvalho, Juliana F. Mazzeu

Hum Mutat. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Hum Mutat. 2022 Jul; 43(7): 900–918. Published online 2022 May 10. doi: 10.1002/humu.24375

PMCID:: PMC9177636

Abstract Article PDF–2.3M

Select item 917141116.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 884482717.

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang

iScience. 2022 Feb 18; 25(2): 103813. Published online 2022 Jan 25. doi: 10.1016/j.isci.2022.103813

PMCID:: PMC8844827

Abstract Article PDF–6.0M

Select item 858218018.

ROR1 and ROR2 expression in pancreatic cancer

Dongli Liu, George Sharbeen, Phoebe Phillips, Australian Pancreatic Cancer Genome Initiative, Caroline E. Ford

BMC Cancer. 2021; 21: 1199. Published online 2021 Nov 11. doi: 10.1186/s12885-021-08952-9

PMCID:: PMC8582180

Abstract Article PDF–2.3M

Select item 855290719.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 855075920.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759

PMCID:: PMC8550759

Abstract Article PDF–7.4M

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