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Items: 1 to 20 of 41

1.
A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens
Yuefang Zhou, Thomas M. Bennett, Philip A. Ruzycki, Zhaohua Guo, Yu-Qing Cao, Mohammad Shahidullah, Nicholas A. Delamere, Alan Shiels
Cells. 2024 Feb; 13(3): 257. Published online 2024 Jan 30. doi: 10.3390/cells13030257
PMCID:
PMC10854584
AbstractArticlePDF–9.0M
2.
Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders
Lydie Burglen, Evelien Van Hoeymissen, Leila Qebibo, Magalie Barth, Newell Belnap, Felix Boschann, Christel Depienne, Katrien De Clercq, Andrew GL Douglas, Mark P Fitzgerald, Nicola Foulds, Catherine Garel, Ingo Helbig, Katharina Held, Denise Horn, Annelies Janssen, Angela M Kaindl, Vinodh Narayanan, Christina Prager, Mailys Rupin-Mas, Alexandra Afenjar, Siyuan Zhao, Vincent Th Ramaekers, Sarah M Ruggiero, Simon Thomas, Stéphanie Valence, Lionel Van Maldergem, Tibor Rohacs, Diana Rodriguez, David Dyment, Thomas Voets, Joris Vriens
eLife. 2023; 12: e81032. Published online 2023 Jan 17. doi: 10.7554/eLife.81032
PMCID:
PMC9886277
AbstractArticlePDF–3.5M
3.
Computational and functional studies of the PI(4,5)P2 binding site of the TRPM3 ion channel reveal interactions with other regulators
Siyuan Zhao, Vincenzo Carnevale, Matthew Gabrielle, Eleonora Gianti, Tibor Rohacs
J Biol Chem. 2022 Nov; 298(11): 102547. Published online 2022 Sep 28. doi: 10.1016/j.jbc.2022.102547
PMCID:
PMC9647539
AbstractArticlePDF–3.9M
4.
The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients
Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines, Sonya Marshall-Gradisnik
J Transl Med. 2021; 19: 306. Published online 2021 Jul 15. doi: 10.1186/s12967-021-02974-4
PMCID:
PMC8281618
AbstractArticlePDF–1.6M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
The structural basis for an on–off switch controlling Gβγ-mediated inhibition of TRPM3 channels
Marc Behrendt, Fabian Gruss, Raissa Enzeroth, Sandeep Dembla, Siyuan Zhao, Pierre-Antoine Crassous, Florian Mohr, Mieke Nys, Nikolaos Louros, Rodrigo Gallardo, Valentina Zorzini, Doris Wagner, Anastassios Economou, Frederic Rousseau, Joost Schymkowitz, Stephan E. Philipp, Tibor Rohacs, Chris Ulens, Johannes Oberwinkler
Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46): 29090–29100. Published online 2020 Oct 29. doi: 10.1073/pnas.2001177117
PMCID:
PMC7682392
AbstractArticlePDF–1.4M
7.
Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes
Jörn Lötsch, Dario Kringel, Gerd Geisslinger, Bruno G. Oertel, Eduard Resch, Sebastian Malkusch
Int J Mol Sci. 2020 Jun; 21(12): 4367. Published online 2020 Jun 19. doi: 10.3390/ijms21124367
PMCID:
PMC7352872
AbstractArticlePDF–3.8M
8.
Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms
Siyuan Zhao, Yevgen Yudin, Tibor Rohacs
eLife. 2020; 9: e55634. Published online 2020 Apr 28. doi: 10.7554/eLife.55634
PMCID:
PMC7255801
AbstractArticlePDF–1.2M
9.
Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy
Evelien Van Hoeymissen, Katharina Held, Ana Cristina Nogueira Freitas, Annelies Janssens, Thomas Voets, Joris Vriens
eLife. 2020; 9: e57190. Published online 2020 May 19. doi: 10.7554/eLife.57190
PMCID:
PMC7253177
AbstractArticlePDF–1.2M
10.
Functional expression and pharmacological modulation of TRPM3 in human sensory neurons
Laura Vangeel, Melissa Benoit, Yannick Miron, Paul E. Miller, Katrien De Clercq, Patrick Chaltin, Catherine Verfaillie, Joris Vriens, Thomas Voets
Br J Pharmacol. 2020 Jun; 177(12): 2683–2695. Published online 2020 Mar 5. doi: 10.1111/bph.14994
PMCID:
PMC7236075
AbstractArticlePDF–3.1M
11.
Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients
Cassandra Balinas, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik
J Transl Med. 2019; 17: 401. Published online 2019 Dec 3. doi: 10.1186/s12967-019-02155-4
PMCID:
PMC6891975
AbstractArticlePDF–1.0M
12.
Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Helene Cabanas, Katsuhiko Muraki, Donald Staines, Sonya Marshall-Gradisnik
Front Immunol. 2019; 10: 2545. Published online 2019 Oct 31. doi: 10.3389/fimmu.2019.02545
PMCID:
PMC6834647
AbstractArticlePDF–1.8M
13.
De novo substitutions of TRPM3 cause intellectual disability and epilepsy
David A. Dyment, Paulien A. Terhal, Cecilie F. Rustad, Kristian Tveten, Christopher Griffith, Parul Jayakar, Marwan Shinawi, Sara Ellingwood, Rosemarie Smith, Koen van Gassen, Kirsty McWalter, A. Micheil Innes, Matthew A. Lines
Eur J Hum Genet. 2019 Oct; 27(10): 1611–1618. Published online 2019 Jul 5. doi: 10.1038/s41431-019-0462-x
PMCID:
PMC6777445
AbstractArticlePDF–1.4M
14.
Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits
Omar Alkhatib, Robson da Costa, Clive Gentry, Talisia Quallo, Stuart Bevan, David A. Andersson
J Neurosci. 2019 Oct 2; 39(40): 7840–7852. doi: 10.1523/JNEUROSCI.0882-19.2019
Correction in:
J Neurosci. 2020 Sep 30; 40(40): 7778.
PMCID:
PMC6774412
AbstractArticlePDF–4.0M
15.
Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines, S. Marshall-Gradisnik
Mol Med. 2019; 25: 14. Published online 2019 Apr 23. doi: 10.1186/s10020-019-0083-4
PMCID:
PMC6480905
AbstractArticlePDF–3.0M
16.
Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines, Sonya Marshall-Gradisnik
Mol Med. 2018; 24: 44. Published online 2018 Aug 14. doi: 10.1186/s10020-018-0046-1
PMCID:
PMC6092868
AbstractArticlePDF–1.3M
17.
A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome
Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar
Mol Cell. Author manuscript; available in PMC 2017 Oct 31.
Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004
PMCID:
PMC5663465
AbstractArticlePDF–2.1M
18.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
19.
CREB, AP‐1, ternary complex factors and MAP kinases connect transient receptor potential melastatin‐3 (TRPM3) channel stimulation with increased c‐Fos expression
Sandra Rubil, Oliver G. Rössler, Gerald Thiel
Br J Pharmacol. 2016 Jan; 173(2): 305–318. Published online 2015 Dec 19. doi: 10.1111/bph.13372
PMCID:
PMC5341230
AbstractArticlePDF–1.7M
20.
Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels
T. Nguyen, S. Johnston, L. Clarke, P. Smith, D. Staines, S. Marshall‐Gradisnik
Clin Exp Immunol. 2017 Feb; 187(2): 284–293. Published online 2016 Nov 23. doi: 10.1111/cei.12882
PMCID:
PMC5217865
AbstractArticlePDF–528K

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