PMC Links for GEO Profiles (Select 74252897) - PMC

Select item 86708431.

Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression

Irena Pastar, Andrew P. Sawaya, Jelena Marjanovic, Jamie L. Burgess, Natasa Strbo, Katelyn E. Rivas, Tongyu C. Wikramanayake, Cheyanne R. Head, Rivka C. Stone, Ivan Jozic, Olivera Stojadinovic, Eran Y. Kornfeld, Robert S. Kirsner, Hadar Lev-Tov, Marjana Tomic-Canic

J Clin Invest. 2021 Dec 15; 131(24): e133727. Published online 2021 Dec 15. doi: 10.1172/JCI133727

PMCID:: PMC8670843

Abstract Article PDF–2.1M

Select item 80070652.

Macrophage-Specific Protein Perforin-2 is Associated with Poor Neurological Recovery and Reduced Survival After Sudden Cardiac Arrest

Sharma Kattel, Hardik Bhatt, Shirley Xu, Sharda Gurung, Saraswati Pokharel, Umesh C Sharma

Resuscitation. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Resuscitation. 2020 Oct; 155: 180–188. Published online 2020 Aug 20. doi: 10.1016/j.resuscitation.2020.08.005

PMCID:: PMC8007065

Abstract Article PDF–798K

Select item 79378643.

Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

Leidy C. Merselis, Zachary P. Rivas, George P. Munson

Front Immunol. 2021; 12: 597951. Published online 2021 Feb 22. doi: 10.3389/fimmu.2021.597951

PMCID:: PMC7937864

Abstract Article PDF–3.2M

Select item 76700694.

MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy

Leidy C. Merselis, Shirley Y. Jiang, Stanley F. Nelson, Hane Lee, Kavitha K. Prabaker, Jennifer L. Baker, George P. Munson, Manish J. Butte

Front Immunol. 2020; 11: 601584. Published online 2020 Nov 3. doi: 10.3389/fimmu.2020.601584

PMCID:: PMC7670069

Abstract Article PDF–1.2M

Select item 76147795.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik

Science. Author manuscript; available in PMC 2023 Jul 19.

Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802

PMCID:: PMC7614779

Abstract Article PDF–1.8M

Select item 74617196.

Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection

N Strbo, I Pastar, L Romero, V Chen, M Vujanac, A.P Sawaya, I Jozic, FA Ferreira, LL Wong, C Head, O Stojadinovic, D Garcia, K O’Neill, S Drakulich, S Taller, RS Kirsner, DR. M Tomic-Canic

Exp Dermatol. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Exp Dermatol. 2019 Mar; 28(3): 225–232. Published online 2019 Feb 12. doi: 10.1111/exd.13870

PMCID:: PMC7461719

Abstract Article PDF–1.0M

Select item 67530887.

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A. Spicer, Ruby H. P. Law, Adrian W. Hodel, Edward S. Parsons, Susan M. Ekkel, Paul J. Conroy, Georg Ramm, Hariprasad Venugopal, Phillip I. Bird, Bart W. Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A. Dunstone, James C. Whisstock

Nat Commun. 2019; 10: 4288. Published online 2019 Sep 19. doi: 10.1038/s41467-019-12279-2

PMCID:: PMC6753088

Abstract Article PDF–2.8M

Select item 46268118.

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack

eLife. 2015; 4: e06508. Published online 2015 Sep 24. doi: 10.7554/eLife.06508

PMCID:: PMC4626811

Abstract Article PDF–4.3M

Select item 46265739.

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

Ryan M McCormack, Kirill Lyapichev, Melissa L Olsson, Eckhard R Podack, George P Munson

eLife. 2015; 4: e06505. Published online 2015 Sep 29. doi: 10.7554/eLife.06505

PMCID:: PMC4626573

Abstract Article PDF–4.5M

Select item 460006110.

Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution

Ryan McCormack, Eckhard R. Podack

J Leukoc Biol. 2015 Nov; 98(5): 761–768. Published online 2015 Aug 25. doi: 10.1189/jlb.4MR1114-523RR

PMCID:: PMC4600061

Abstract Article

Select item 438092811.

Phospho-tyrosine dependent protein–protein interaction network

Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968

PMCID:: PMC4380928

Abstract Article PDF–1.9M

Select item 374693212.

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

Tory P. Johnson, Karan Patel, Kory R. Johnson, Dragan Maric, Peter A. Calabresi, Rodrigo Hasbun, Avindra Nath

Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33): 13588–13593. Published online 2013 Jul 29. doi: 10.1073/pnas.1308673110

PMCID:: PMC3746932

Abstract Article PDF–1002K

Select item 373247713.

Inhibition of Intracellular Bacterial Replication in Fibroblasts Is Dependent on the Perforin-Like Protein (Perforin-2) Encoded by Macrophage-Expressed Gene 1

Ryan McCormack, Lesley R. de Armas, Motoaki Shiratsuchi, Jahir E. Ramos, Eckhard R. Podack

J Innate Immun. 2013 Mar; 5(2): 185–194. Published online 2012 Dec 15. doi: 10.1159/000345249

PMCID:: PMC3732477

Abstract Article PDF–298K

Select item 371955514.

Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages

K. A. Fields, R. McCormack, L. R. de Armas, E. R. Podack

Infect Immun. 2013 Aug; 81(8): 3045–3054. doi: 10.1128/IAI.00497-13

PMCID:: PMC3719555

Abstract Article PDF–2.1M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 135612916.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 13924117.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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