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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 103521922.

The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome

Xujing Deng, Qing Sang, Ruixiu Zhang, Jian Mu, Shihua Bao

J Assist Reprod Genet. 2023 Jul; 40(7): 1703–1712. Published online 2023 May 27. doi: 10.1007/s10815-023-02829-5

PMCID:: PMC10352192

Abstract Article PDF–1009K

Select item 99342993.

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes

Asma Tlili, Coralie Pintard, Margarita Hurtado-Nedelec, Dan Liu, Viviana Marzaioli, Nathalie Thieblemont, Pham My-Chan Dang, Jamel El-Benna

Proc Natl Acad Sci U S A. 2023 Jan 17; 120(3): e2209184120. Published online 2023 Jan 10. doi: 10.1073/pnas.2209184120

PMCID:: PMC9934299

Abstract Article PDF–1.8M

Select item 98677624.

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I

Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang

Cell Death Dis. 2023 Jan; 14(1): 50. Published online 2023 Jan 21. doi: 10.1038/s41419-023-05581-x

PMCID:: PMC9867762

Abstract Article PDF–4.9M

Select item 95128015.

A dual Keap1 and p47^phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun

Cell Death Dis. 2022 Sep; 13(9): 824. Published online 2022 Sep 26. doi: 10.1038/s41419-022-05274-x

PMCID:: PMC9512801

Abstract Article PDF–6.7M

Select item 85455306.

NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma

Yifei Chen, Fei He, Ruhua Wang, Menglin Yao, Yarui Li, Dan Guo, Shuixiang He

Biomed Res Int. 2021; 2021: 5954036. Published online 2021 Oct 18. doi: 10.1155/2021/5954036

PMCID:: PMC8545530

Abstract Article PDF–7.3M

Select item 83577277.

Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis

Daan Fritz, Bart Ferwerda, Matthijs C. Brouwer, Diederik van de Beek

Clin Rheumatol. 2021; 40(9): 3735–3743. Published online 2021 Apr 27. doi: 10.1007/s10067-021-05684-w

PMCID:: PMC8357727

Abstract Article PDF–365K

Select item 82203918.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 684200411.

Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

Nozomi Yokoyama, Aya Kawasaki, Takashi Matsushita, Hiroshi Furukawa, Yuya Kondo, Fumio Hirano, Ken-ei Sada, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Shouhei Nagaoka, Keigo Setoguchi, Tatsuo Nagai, Kota Shimada, Shoji Sugii, Atsushi Hashimoto, Toshihiro Matsui, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Shigeru Ohno, Masao Katayama, Kiyoshi Migita, Hajime Kono, Minoru Hasegawa, Shigeto Kobayashi, Hidehiro Yamada, Kenji Nagasaka, Takahiko Sugihara, Kunihiro Yamagata, Shoichi Ozaki, Naoto Tamura, Yoshinari Takasaki, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Shinichi Sato, Takayuki Sumida, Shigeto Tohma, Kazuhiko Takehara, Naoyuki Tsuchiya

Sci Rep. 2019; 9: 16366. Published online 2019 Nov 8. doi: 10.1038/s41598-019-52920-0

PMCID:: PMC6842004

Abstract Article PDF–1.1M

Select item 682959912.

Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils

Delphine Ohayon, Alessia De Chiara, Pham My-Chan Dang, Nathalie Thieblemont, Simon Chatfield, Viviana Marzaioli, Sabrina Sofia Burgener, Julie Mocek, Céline Candalh, Coralie Pintard, Pascale Tacnet-Delorme, Gilles Renault, Isabelle Lagoutte, Maryline Favier, Francine Walker, Margarita Hurtado-Nedelec, Dominique Desplancq, Etienne Weiss, Charaf Benarafa, Dominique Housset, Jean-Claude Marie, Philippe Frachet, Jamel El-Benna, Véronique Witko-Sarsat

J Exp Med. 2019 Nov 4; 216(11): 2669–2687. Published online 2019 Sep 6. doi: 10.1084/jem.20180371

Correction in:: J Exp Med. 2019 Dec 2; 216(12): 2900.

PMCID:: PMC6829599

Abstract Article PDF–3.4M

Select item 634428613.

Redox Activation of Nox1 Involves an Intermolecular Disulfide Bond between Protein Disulfide Isomerase and p47^phox in Vascular Smooth Muscle Cells

Marcela Gimenez, Sidney Veríssimo-Filho, Ilka Wittig, Brandon M. Schickling, Fabian Hahner, Christoph Schürmann, Luis E.S. Netto, José César Rosa, Ralf P. Brandes, Simone Sartoretto, Lívia De Lucca Camargo, Fernando Abdulkader, Francis J. Miller, Jr., Lucia Rossetti Lopes

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Feb; 39(2): 224–236. doi: 10.1161/ATVBAHA.118.311038

PMCID:: PMC6344286

Abstract Article PDF–950K

Select item 634119014.

NCF1 (p47^phox)–deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis

Douglas B. Kuhns, Amy P. Hsu, David Sun, Karen Lau, Danielle Fink, Paul Griffith, Da Wei Huang, Debra A. Long Priel, Laura Mendez, Samantha Kreuzburg, Christa S. Zerbe, Suk See De Ravin, Harry L. Malech, Steven M. Holland, Xiaolin Wu, John I. Gallin

Blood Adv. 2019 Jan 22; 3(2): 136–147. Published online 2019 Jan 16. doi: 10.1182/bloodadvances.2018023184

PMCID:: PMC6341190

Abstract Article PDF–1.4M

Select item 618920915.

Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils

Yebin Zhou, Ling-Ling An, Raghothama Chaerkady, Nanette Mittereder, Lori Clarke, Taylor S. Cohen, Bo Chen, Sonja Hess, Gary P. Sims, Tomas Mustelin

Sci Rep. 2018; 8: 15228. Published online 2018 Oct 15. doi: 10.1038/s41598-018-33385-z

PMCID:: PMC6189209

Abstract Article PDF–2.8M

Select item 588909316.

Suppressed ubiquitination of Nrf2 by p47^phox contributes to Nrf2 activation

Kyun Ha Kim, Ruxana T. Sadikot, Ji Yeon Lee, Han-Sol Jeong, Yu-Kyoung Oh, Timothy S. Blackwell, Myungsoo Joo

Free Radic Biol Med. Author manuscript; available in PMC 2018 Apr 6.

Published in final edited form as: Free Radic Biol Med. 2017 Dec; 113: 48–58. Published online 2017 Sep 19. doi: 10.1016/j.freeradbiomed.2017.09.011

PMCID:: PMC5889093

Abstract Article PDF–1.8M

Select item 581805517.

Tks adaptor proteins at a glance

Priyanka Saini, Sara A. Courtneidge

J Cell Sci. 2018 Jan 1; 131(1): jcs203661. doi: 10.1242/jcs.203661

PMCID:: PMC5818055

Abstract Article

Select item 563754618.

CYBA encoding p22^phox, the cytochrome b₅₅₈ alpha polypeptide: gene structure, expression, role and physiopathology

Marie José Stasia

Gene. Author manuscript; available in PMC 2017 Oct 12.

Published in final edited form as: Gene. 2016 Jul 15; 586(1): 27–35. Published online 2016 Apr 2. doi: 10.1016/j.gene.2016.03.050

PMCID:: PMC5637546

Abstract Article PDF–632K

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 540009820.

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

Jian Zhao, Jianyang Ma, Yun Deng, Jennifer A. Kelly, Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Quan-Zhen Li, Edward K. Wakeland, Rong Qiu, Mengru Liu, Jianping Guo, Zhanguo Li, Wenfeng Tan, Astrid Rasmussen, Christopher J. Lessard, Kathy L. Sivils, Bevra H. Hahn, Jennifer M. Grossman, Diane L. Kamen, Gary S. Gilkeson, Sang-Cheol Bae, Patrick M. Gaffney, Nan Shen, Betty P. Tsao

Nat Genet. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Nat Genet. 2017 Mar; 49(3): 433–437. Published online 2017 Jan 30. doi: 10.1038/ng.3782

PMCID:: PMC5400098

Abstract Article PDF–480K

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