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Select item 112901021.

Genetic variation at a splicing branch point in intron 7 of STK11: a rare variant decreasing its expression in a Chinese family with Peutz–Jeghers syndrome

Xiufang Wang, Yuanyuan Li, Jingqiong Zhang, Chao Liu, Aiping Deng, Juyi Li

World J Surg Oncol. 2024; 22: 202. Published online 2024 Jul 30. doi: 10.1186/s12957-024-03475-6

PMCID:: PMC11290102

Abstract Article PDF–3.3M

Select item 111588712.

LKB1 gene mutations in Japanese lung cancer patients

Ryoichi Onozato, Takayuki Kosaka, Hiroyuki Achiwa, Hiroyuki Kuwano, Takashi Takahashi, Yasushi Yatabe, Tetsuya Mitsudomi

Cancer Sci. 2007 Nov; 98(11): 1747–1751. Published online 2007 Aug 16. doi: 10.1111/j.1349-7006.2007.00585.x

PMCID:: PMC11158871

Abstract Article PDF–116K

Select item 111270503.

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase

John R. Ferrarone, Jerin Thomas, Arun M. Unni, Yuxiang Zheng, Michal J. Nagiec, Eric E. Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C. Cantley, John Blenis, Neville E. Sanjana, Harold Varmus

Proc Natl Acad Sci U S A. 2024 May 21; 121(21): e2403685121. Published online 2024 May 14. doi: 10.1073/pnas.2403685121

PMCID:: PMC11127050

Abstract Article PDF–1.4M

Select item 110251844.

Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non-small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics analyses

Ke Xu, Weinan Lu, Airu Yu, Hongwei Wu, Jie He

BMC Cancer. 2024; 24: 491. Published online 2024 Apr 17. doi: 10.1186/s12885-024-12130-y

PMCID:: PMC11025184

Abstract Article PDF–3.1M

Select item 109805595.

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

Biagio Ricciuti, Kathryn C. Arbour, Jessica J. Lin, Amir Vajdi, Natalie Vokes, Lingzhi Hong, Jianjun Zhang, Michael Y. Tolstorukov, Yvonne Y. Li, Liam F. Spurr, Andrew D. Cherniack, Gonzalo Recondo, Giuseppe Lamberti, Xinan Wang, Deepti Venkatraman, Joao V. Alessi, Victor R. Vaz, Hira Rizvi, Jacklynn Egger, Andrew J. Plodkowski, Sara Khosrowjerdi, Subba Digumarthy, Hyesun Park, Nuno Vaz, Mizuki Nishino, Lynette M. Sholl, David Barbie, Mehmet Altan, John V. Heymach, Ferdinandos Skoulidis, Justin F. Gainor, Matthew D. Hellmann, Mark M. Awad

J Thorac Oncol. Author manuscript; available in PMC 2024 Mar 29.

Published in final edited form as: J Thorac Oncol. 2022 Mar; 17(3): 399–410. Published online 2021 Nov 2. doi: 10.1016/j.jtho.2021.10.013

PMCID:: PMC10980559

Abstract Article PDF–1.5M

Select item 109380036.

Impact of LKB1 status on radiation outcome in patients with stage III non-small-cell lung cancer

Piyada Sitthideatphaiboon, Chonnipa Nantavithya, Poonchavist Chantranuwat, Chanida Vinayanuwattikun, Virote Sriuranpong

Sci Rep. 2024; 14: 6146. Published online 2024 Mar 14. doi: 10.1038/s41598-024-55476-w

PMCID:: PMC10938003

Abstract Article PDF–1.2M

Select item 107941397.

STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines

Sean M. Lenahan, Hailey M. Sarausky, Paula Deming, David J. Seward

Cancer Gene Ther. 2024; 31(1): 1–8. Published online 2023 Nov 15. doi: 10.1038/s41417-023-00687-y

PMCID:: PMC10794139

Abstract Article PDF–4.1M

Select item 107016018.

LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub

EMBO Mol Med. 2023 Dec; 15(12): e17719. Published online 2023 Nov 15. doi: 10.15252/emmm.202317719

Correction in:: EMBO Mol Med. 2024 Sep; 16(9): 2262–2267.

PMCID:: PMC10701601

Abstract Article PDF–3.7M

Select item 105688209.

DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy

Ning Wu, Jinzhong Ji, Xiaoqin Gou, Pan Hu, Yao Cheng, Yuhang Liu, Yuanying Wang, Qilong Zhang, Li Zuo

Virol J. 2023; 20: 231. Published online 2023 Oct 11. doi: 10.1186/s12985-023-02166-0

PMCID:: PMC10568820

Abstract Article PDF–2.1M

Select item 1053042210.

STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non–Small-Cell Lung Cancer

Rohan R. Katipally, Liam F. Spurr, Stanley I. Gutiontov, William Tyler Turchan, Philip Connell, Aditya Juloori, Renuka Malik, Michael S. Binkley, Alice L. Jiang, Sherin J. Rouhani, Carolina Soto Chervin, Pankhuri Wanjari, Jeremy P. Segal, Victor Ng, Billy W. Loo, Daniel R. Gomez, Christine M. Bestvina, Everett E. Vokes, Mark K. Ferguson, Jessica S. Donington, Maximilian Diehn, Sean P. Pitroda

JCO Precis Oncol. 2023; 7: e2200273. Published online 2023 Jan 5. doi: 10.1200/PO.22.00273

PMCID:: PMC10530422

Abstract Article PDF–639K

Select item 1034791911.

Alteration of STK11 Expression Associated With Cholangiocarcinoma Progression

PAPITCHAYA SIRITHAWAT, APINYA JUSAKUL, SARINYA KONGPETCH, MALINEE THANEE, PEERADA SRICHANCHARA, SUPARADA PANJAROENSAK, PHONGSARAN KIMAWAHA, SUTTHIWAN JANTHAMALA, CHAIWAT APHIVATANASIRI, ANCHALEE TECHASEN

In Vivo. 2023 Jul-Aug; 37(4): 1638–1648. Published online 2023 Jul 3. doi: 10.21873/invivo.13249

PMCID:: PMC10347919

Abstract Article PDF–5.4M

Select item 1034446712.

STK11 Alterations in the Pan-Cancer Setting: Prognostic and Therapeutic Implications

Nithya Krishnamurthy, Aaron M. Goodman, Donald A. Barkauskas, Razelle Kurzrock

Eur J Cancer. Author manuscript; available in PMC 2023 Jul 13.

Published in final edited form as: Eur J Cancer. 2021 May; 148: 215–229. Published online 2021 Mar 19. doi: 10.1016/j.ejca.2021.01.050

PMCID:: PMC10344467

Abstract Article PDF–1.0M

Select item 1029214813.

Peutz-Jeghers syndrome without STK11 mutation may correlate with less severe clinical manifestations in Chinese patients

Li-Xin Jiang, Yu-Rui Chen, Zu-Xin Xu, Yu-Hui Zhang, Zhi Zhang, Peng-Fei Yu, Zhi-Wei Dong, Hai-Rui Yang, Guo-Li Gu

World J Gastroenterol. 2023 Jun 7; 29(21): 3302–3317. Published online 2023 Jun 7. doi: 10.3748/wjg.v29.i21.3302

PMCID:: PMC10292148

Abstract Article PDF–1.3M

Select item 1024382014.

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante

JCI Insight. 2023 Apr 24; 8(8): e165419. Published online 2023 Apr 24. doi: 10.1172/jci.insight.165419

PMCID:: PMC10243820

Abstract Article PDF–6.8M

Select item 1023505315.

Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis

Guojiang Tan, Baiying Liu

Sci Rep. 2023; 13: 8937. Published online 2023 Jun 1. doi: 10.1038/s41598-023-36239-5

PMCID:: PMC10235053

Abstract Article PDF–2.5M

Select item 1017711916.

LKB1 Regulates Inflammation of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis via AMPK-Dependent SLC7A11-NOX4-ROS Signaling

Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Seong Wook Kang

Cells. 2023 May; 12(9): 1263. Published online 2023 Apr 26. doi: 10.3390/cells12091263

PMCID:: PMC10177119

Abstract Article PDF–6.6M

Select item 1015364917.

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu

Cell Rep. Author manuscript; available in PMC 2023 May 2.

Published in final edited form as: Cell Rep. 2022 Oct 18; 41(3): 111498. doi: 10.1016/j.celrep.2022.111498

PMCID:: PMC10153649

Abstract Article PDF–1.6M

Select item 1011932218.

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi

Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x