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Select item 110280841.

Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature

Emily Hinchcliff, Cherie Paquette, Jason Roszik, Sarah Kelting, Mark H. Stoler, Samuel C. Mok, Tsz-Lun Yeung, Qian Zhang, Melinda Yates, Weiyi Peng, Patrick Hwu, Amir Jazaeri

Cancer Immunol Immunother. 2019 Sep; 68(9): 1515–1526. Published online 2019 Sep 12. doi: 10.1007/s00262-019-02385-x

PMCID:: PMC11028084

Abstract Article PDF–1.5M

Select item 107306912.

Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK

Baerbel Keller, Shlomit Kfir-Erenfeld, Paul Matusewicz, Frederike Hartl, Atar Lev, Yu Nee Lee, Amos J. Simon, Tali Stauber, Orly Elpeleg, Raz Somech, Polina Stepensky, Susana Minguet, Burkhart Schraven, Klaus Warnatz

J Clin Immunol. 2024; 44(1): 4. Published online 2023 Dec 19. doi: 10.1007/s10875-023-01614-4

PMCID:: PMC10730691

Abstract Article PDF–7.3M

Select item 107243243.

A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature

Anna-Lisa Lanz, Serife Erdem, Alper Ozcan, Gulay Ceylaner, Murat Cansever, Serdar Ceylaner, Raffaele Conca, Thomas Magg, Oreste Acuto, Sylvain Latour, Christoph Klein, Turkan Patiroglu, Ekrem Unal, Ahmet Eken, Fabian Hauck

J Clin Immunol. 2024; 44(1): 1. Published online 2023 Dec 15. doi: 10.1007/s10875-023-01602-8

Correction in:: J Clin Immunol. 2024; 44(1): 41.

PMCID:: PMC10724324

Abstract Article PDF–1.6M

Select item 104879174.

Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization

Fatma Al Qutami, Walaa Al Halabi, Mahmood Y. Hachim

Int J Mol Sci. 2023 Sep; 24(17): 13269. Published online 2023 Aug 26. doi: 10.3390/ijms241713269

PMCID:: PMC10487917

Abstract Article PDF–7.8M

Select item 104805355.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 102945096.

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer

Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes

J Ovarian Res. 2023; 16: 122. Published online 2023 Jun 27. doi: 10.1186/s13048-023-01194-2

PMCID:: PMC10294509

Abstract Article PDF–8.5M

Select item 100729067.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 97339378.

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Von Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L. Safgren, Yi-Chien Tsai, Beat Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D. Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos

Sci Adv. 2022 Dec; 8(49): eabq8437. Published online 2022 Dec 9. doi: 10.1126/sciadv.abq8437

PMCID:: PMC9733937

Abstract Article PDF–2.2M

Select item 94550829.

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling

Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni

Cells. 2022 Sep; 11(17): 2723. Published online 2022 Sep 1. doi: 10.3390/cells11172723

PMCID:: PMC9455082

Abstract Article PDF–1.7M

Select item 910523510.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 908800011.

Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5⁺ Innate-Like B Cells

Jiajun Zhou, Lance K. Blevins, Robert B. Crawford, Norbert E. Kaminski

Front Immunol. 2022; 13: 884203. Published online 2022 Apr 26. doi: 10.3389/fimmu.2022.884203

PMCID:: PMC9088000

Abstract Article PDF–5.7M

Select item 861639012.

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL

Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado, Ana C. Carrera

Cells. 2021 Nov; 10(11): 2803. Published online 2021 Oct 20. doi: 10.3390/cells10112803

PMCID:: PMC8616390

Abstract Article PDF–4.6M

Select item 821170013.

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx

Nat Commun. 2021; 12: 3705. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24037-4

PMCID:: PMC8211700

Abstract Article PDF–5.6M

Select item 819417914.

Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation

Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner

Mol Cancer. 2021; 20: 88. Published online 2021 Jun 11. doi: 10.1186/s12943-021-01384-w

Correction in:: Mol Cancer. 2023; 22: 50.

PMCID:: PMC8194179

Abstract Article PDF–5.0M

Select item 806802615.

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

Frederike A. Hartl, Jatuporn Ngoenkam, Esmeralda Beck-Garcia, Liz Cerqueira, Piyamaporn Wipa, Pussadee Paensuwan, Prapat Suriyaphol, Pankaj Mishra, Burkhart Schraven, Stefan Günther, Sutatip Pongcharoen, Wolfgang W. A. Schamel, Susana Minguet

Cells. 2021 Apr; 10(4): 834. Published online 2021 Apr 7. doi: 10.3390/cells10040834

PMCID:: PMC8068026

Abstract Article PDF–1.4M

Select item 797970516.

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu

NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3

PMCID:: PMC7979705

Abstract Article PDF–6.8M

Select item 791531217.

A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling

Inmaculada Vico-Barranco, Mikel M. Arbulo-Echevarria, Isabel Serrano-García, Alba Pérez-Linaza, José M. Miranda-Sayago, Arkadiusz Miazek, Isaac Narbona-Sánchez, Enrique Aguado

Cells. 2021 Feb; 10(2): 343. Published online 2021 Feb 6. doi: 10.3390/cells10020343

PMCID:: PMC7915312

Abstract Article PDF–2.3M

Select item 779597118.

The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37

Sarah Kowallik, Andreas Kritikos, Matthias Kästle, Christoph Thurm, Burkhart Schraven, Luca Simeoni

Int J Mol Sci. 2021 Jan; 22(1): 126. Published online 2020 Dec 24. doi: 10.3390/ijms22010126

PMCID:: PMC7795971

Abstract Article PDF–1.7M

Select item 768201819.

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56^Lck regulates T-cell activation independently of Lck/CD45 interactions

Matthias Kästle, Camilla Merten, Roland Hartig, Thilo Kaehne, Ardiyanto Liaunardy-Jopeace, Nadine M. Woessner, Wolfgang W. Schamel, John James, Susana Minguet, Luca Simeoni, Burkhart Schraven

Cell Commun Signal. 2020; 18: 183. Published online 2020 Nov 23. doi: 10.1186/s12964-020-00673-z

PMCID:: PMC7682018

Abstract Article PDF–3.7M

Select item 742732720.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

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