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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99833162.

Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A‐RUNX2 pathway

Subin Weon, Sungsin Jo, Bora Nam, Sung Hoon Choi, Ye‐Soo Park, Yong‐Gil Kim, Tae‐Hwan Kim

J Cell Mol Med. 2023 Mar; 27(5): 650–658. Published online 2023 Feb 9. doi: 10.1111/jcmm.17685

PMCID:: PMC9983316

Abstract Article PDF–2.4M

Select item 95248253.

Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage

Dayun Feng, Jinpeng Zhou, Haixiao Liu, Xun Wu, Fei Li, Junlong Zhao, Yu Zhang, Lei Wang, Min Chao, Qiang Wang, Huaizhou Qin, Shunnan Ge, Qiang Liu, Jian Zhang, Yan Qu

Sci Adv. 2022 Sep; 8(39): eabq2423. Published online 2022 Sep 30. doi: 10.1126/sciadv.abq2423

PMCID:: PMC9524825

Abstract Article PDF–13M

Select item 93391864.

TRIM18 is a critical regulator of viral myocarditis and organ inflammation

Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing, Zhiqiang Zhang

J Biomed Sci. 2022; 29: 55. Published online 2022 Jul 31. doi: 10.1186/s12929-022-00840-z

PMCID:: PMC9339186

Abstract Article PDF–5.2M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92643636.

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex

Peristera Roboti, Craig Lawless, Stephen High

J Cell Sci. 2022 May 1; 135(9): jcs259596. Published online 2022 May 11. doi: 10.1242/jcs.259596

PMCID:: PMC9264363

Abstract Article

Select item 89832407.

The Effect of the NFκB-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Xiaoqiu Yuan, Yongfei Guo, Jilu Liu, Jingchuan Sun, Lei Shi, Jinhao Miao, Jiangang Shi, Yu Chen

Oxid Med Cell Longev. 2022; 2022: 1604932. Published online 2022 Mar 29. doi: 10.1155/2022/1604932

PMCID:: PMC8983240

Abstract Article PDF–1.9M

Select item 89433268.

A comprehensive overview of PPM1A: From structure to disease

Mao Li, Xingfeng Xu, Yan Su, Xiaoyun Shao, Yali Zhou, Jianguo Yan

Exp Biol Med (Maywood) 2022 Mar; 247(6): 453–461. Published online 2021 Dec 3. doi: 10.1177/15353702211061883

PMCID:: PMC8943326

Abstract Article PDF–1.0M

Select item 83133499.

lncRNA TSPEAR-AS2, a Novel Prognostic Biomarker, Promotes Oral Squamous Cell Carcinoma Progression by Upregulating PPM1A via Sponging miR-487a-3p

Yi-chao Xia, Jun Cao, Jing Yang, Ying Zhang, Yong-sheng Li

Dis Markers. 2021; 2021: 2217663. Published online 2021 Jul 17. doi: 10.1155/2021/2217663

PMCID:: PMC8313349

Abstract Article PDF–2.6M

Select item 829185310.

MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A

Lishan Wang, Shuqing Ge, Futing Zhou

Bioengineered. 2021; 12(1): 937–947. Published online 2021 Mar 16. doi: 10.1080/21655979.2021.1884396

PMCID:: PMC8291853

Abstract Article PDF–3.1M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 780840812.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S. Jureka, Kirsten Obernier, Jeffrey Z. Guo, Jyoti Batra, Robyn M. Kaake, Andrew R. Weckstein, Tristan W. Owens, Meghna Gupta, Sergei Pourmal, Erron W. Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Zeynep Cakir, Gwendolyn Jang, Matthew J. O’Meara, Tia A. Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L. Swaney, Jacqueline M. Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M. Haas, Zun Zar Chi Naing, Ernst H. Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair Dunham, Miguel Correa Marrero, David Burke, Cassandra Koh, Thomas Vallet, Jesus A. Silvas, Caleigh M. Azumaya, Christian Billesbølle, Axel F. Brilot, Melody G. Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nick Hoppe, Huong T. Kratochvil, Yanxin Liu, Gregory E. Merz, Michelle Moritz, Henry C. Nguyen, Carlos Nowotny, Cristina Puchades, Alexandrea N. Rizo, Ursula Schulze-Gahmen, Amber M. Smith, Ming Sun, Iris D. Young, Jianhua Zhao, Daniel Asarnow, Justin Biel, Alisa Bowen, Julian R. Braxton, Jen Chen, Cynthia M. Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Kate Kim, Victor L. Lam, Fei Li, Junrui Li, Yen-Li Li, Yang Li, Xi Liu, Megan Lo, Kyle E. Lopez, Arthur A. Melo, Frank R. Moss, III, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K. Peters, Thomas H. Pospiech, Jr., Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V. Thomas, Aye C. Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Yang Zhang, Fengbo Zhou, Daniel Saltzberg, QCRG Structural Biology Consortium, Anthony J. Hodder, Amber S. Shun-Shion, Daniel M. Williams, Kris M. White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H. Patel, Suzannah Rihn, Mir M. Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R. Simoneau, Theodore L. Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James Logue, Marisa McGrath, Stuart Weston, Robert Haupt, C. James Hastie, Matthew Elliott, Fiona Brown, Kerry A. Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G. Wilkinson, Anna Geyer, Daniel M. Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C. Keough, Abigail L. Lind, Zoonomia Consortium, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S. Pollard, Andrej Sali, David A. Agard, Yifan Cheng, James S. Fraser, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R. Southworth, Robert M. Stroud, Dario R. Alessi, Paul Davies, Matthew B. Frieman, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian Shoichet, Melanie Ott, Massimo Palmarini, Kevan M. Shokat, Adolfo García-Sastre, Jeremy A. Rassen, Robert Grosse, Oren S. Rosenberg, Kliment A. Verba, Christopher F. Basler, Marco Vignuzzi, Andrew A. Peden, Pedro Beltrao, Nevan J. Krogan

Science. 2020 Dec 4; 370(6521): eabe9403. Published online 2020 Oct 15. doi: 10.1126/science.abe9403

PMCID:: PMC7808408

Abstract Article PDF–4.2M

Select item 721869113.

Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis

Beomgu Lee, You Seon Song, Christopher Rhodes, Tae Sik Goh, Jong Seong Roh, Hoim Jeong, Jisu Park, Han-Na Lee, Seung-Geun Lee, Soohyun Kim, Mingyo Kim, Sang-Il Lee, Dong Hyun Sohn, William H. Robinson

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Feb 12.

Published in final edited form as: Biochem Biophys Res Commun. 2020 Feb 12; 522(3): 731–735. Published online 2019 Nov 30. doi: 10.1016/j.bbrc.2019.11.112

PMCID:: PMC7218691

Abstract Article PDF–1005K

Select item 707225414.

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273

Keon Woo Khim, Sun Sil Choi, Hyun-Jun Jang, Yo Han Lee, Eujin Lee, Ji-Min Hyun, Hye-Jin Eom, Sora Yoon, Jeong-Won Choi, Tae-Eun Park, Dougu Nam, Jang Hyun Choi

Cells. 2020 Feb; 9(2): 343. Published online 2020 Feb 2. doi: 10.3390/cells9020343

PMCID:: PMC7072254

Abstract Article PDF–3.0M

Select item 698120615.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 692775416.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 672605417.

A Protein Phosphatase 2cα-Ca²⁺ Channel Complex for Dephosphorylation of Neuronal Ca²⁺ Channels Phosphorylated by Protein Kinase C

Dongjun Li, Fushun Wang, Meizan Lai, Yuan Chen, Ji-fang Zhang

J Neurosci. 2005 Feb 23; 25(8): 1914–1923. doi: 10.1523/JNEUROSCI.4790-04.2005

PMCID:: PMC6726054

Abstract Article PDF–533K

Select item 630936618.

PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

Xia Lin, Xueyan Duan, Yao-Yun Liang, Ying Su, Katharine H. Wrighton, Jianyin Long, Min Hu, Candi M. Davis, Jinrong Wang, F. Charles Brunicardi, Yigong Shi, Ye-Guang Chen, Anming Meng, Xin-Hua Feng

Cell. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: Cell. 2006 Jun 2; 125(5): 915–928. doi: 10.1016/j.cell.2006.03.044

PMCID:: PMC6309366

Abstract Article PDF–3.3M

Select item 623429219.

The Cellular Senescence-Inhibited Gene Is Essential for PPM1A Myristoylation To Modulate Transforming Growth Factor β Signaling

Feng Zhu, Nan Xie, Zhe Jiang, Guodong Li, Liwei Ma, Tanjun Tong

Mol Cell Biol. 2018 Dec 1; 38(23): e00414-18. Prepublished online 2018 Sep 10. Published online 2018 Nov 13. doi: 10.1128/MCB.00414-18

PMCID:: PMC6234292

Abstract Article PDF–2.3M

Select item 616668220.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

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