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Select item 111864551.

Tracking protein–protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b₅

Alaina M. Richard, D. Fernando Estrada, Liam Flynn, Susan Sondej Pochapsky, Emily E. Scott, Thomas C. Pochapsky

Phys Chem Chem Phys. 2024 Jun 19; 26(24): 16980–16988. Published online 2024 May 31. doi: 10.1039/d4cp01268b

PMCID:: PMC11186455

Abstract Article

Select item 108787932.

Proteomics, modeling, and fluorescence assays delineate cytochrome b₅ residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase

Yasuhiro Tateishi, Stephany N. Webb, Bian Li, Lu Liu, Kristie Lindsey Rose, Micheal Leser, Purvi Patel, F. Peter Guengerich

J Biol Chem. 2024 Mar; 300(3): 105688. Published online 2024 Jan 26. doi: 10.1016/j.jbc.2024.105688

PMCID:: PMC10878793

Abstract Article PDF–2.3M

Select item 104994823.

Genotype Frequencies of 50 Polymorphisms for 241 Japanese Non-cancer Patients

Nobuyuki Hamajima, Toshiko Saito, Keitaro Matsuo, Takashi Suzuki, Tsuneya Nakamura, Akio Matsuura, Katashi Okuma, Kazuo Tajima

J Epidemiol. 2002; 12(3): 229–236. Published online 2007 Nov 30. doi: 10.2188/jea.12.229

PMCID:: PMC10499482

Abstract Article PDF–588K

Select item 104407804.

CYP17A1 (rs74357) polymorphism and polycystic ovary syndrome risk: A systemic review and meta-analysis

Mohamed Larbi Rezgoun, Djihan El Khour, Hiba Bendaoud, Djalila Chellat

Acta Biomed. 2023; 94(4): e2023167. Published online 2023 Aug 3. doi: 10.23750/abm.v94i4.14229

PMCID:: PMC10440780

Abstract Article PDF–3.5M

Select item 103094465.

Combined Effect of the PGR +331C > T, CYP17A1 -34A > G and CYP19A1 1531G > A Polymorphisms on the Risk of Developing Endometriosis

Jéssica Vilarinho Cardoso, Daniel Escorsim Machado, Renato Ferrari, Mayara Calixto da Silva, Plínio Tostes Berardo, Jamila Alessandra Perini

Rev Bras Ginecol Obstet. 2017 Jun; 39(6): 273–281. Published online 2017 Jun 14. doi: 10.1055/s-0037-1604097

PMCID:: PMC10309446

Abstract Article PDF–292K

Select item 102944736.

Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease

Ting-Ting Wu, Ying-Ying Zheng, Xiang Ma, Wen-Juan Xiu, Hai-Tao Yang, Xian-Geng Hou, Yi Yang, You Chen, Yi-Tong Ma, Xiang Xie

Cell Commun Signal. 2023; 21: 155. Published online 2023 Jun 27. doi: 10.1186/s12964-023-01061-z

PMCID:: PMC10294473

Abstract Article PDF–6.0M

Select item 99728517.

The importance of Asparagine 202 in manipulating active site structure and substrate preference for human CYP17A1

Yilin Liu, Ilia Denisov, Michael Gregory, Stephen G. Sligar, James R. Kincaid

Biochemistry. Author manuscript; available in PMC 2023 Apr 5.

Published in final edited form as: Biochemistry. 2022 Apr 5; 61(7): 583–594. Published online 2022 Mar 15. doi: 10.1021/acs.biochem.2c00023

PMCID:: PMC9972851

Abstract Article PDF–1.5M

Select item 98923038.

Hydroxylation and Lyase Reactions of Steroids Catalyzed by Mouse Cytochrome P450 17A1 (Cyp17a1)

Sung-Gyu Lee, Vitchan Kim, Gyu-Hyeong Lee, Changmin Kim, Eunseo Jeong, F. Peter Guengerich, Donghak Kim

J Inorg Biochem. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: J Inorg Biochem. 2023 Mar; 240: 112085. Published online 2023 Jan 10. doi: 10.1016/j.jinorgbio.2022.112085

PMCID:: PMC9892303

Abstract Article PDF–857K

Select item 97976739.

Clinical characteristics and molecular etiology of partial 17α-hydroxylase deficiency diagnosed in 46,XX patients

Duoduo Zhang, Fengxia Yao, Min Luo, Yanfang Wang, Tiffany Tian, Shan Deng, Qinjie Tian

Front Endocrinol (Lausanne) 2022; 13: 978026. Published online 2022 Dec 15. doi: 10.3389/fendo.2022.978026

PMCID:: PMC9797673

Abstract Article PDF–5.4M

Select item 960449710.

A Role of DNA Methylation within the CYP17A1 Gene in the Association of Genetic and Environmental Risk Factors with Stress-Related Manifestations of Schizophrenia

Margarita Alfimova, Nikolay Kondratyev, Galina Korovaitseva, Tatyana Lezheiko, Victoria Plakunova, Marina Gabaeva, Vera Golimbet

Int J Mol Sci. 2022 Oct; 23(20): 12629. Published online 2022 Oct 20. doi: 10.3390/ijms232012629

PMCID:: PMC9604497

Abstract Article PDF–1.9M

Select item 912086811.

Aberrant H19 Expression Disrupts Ovarian Cyp17 and Testosterone Production and Is Associated with Polycystic Ovary Syndrome in Women

Zhaojuan Chen, Lan Liu, Xia Xi, Martina Burn, Cengiz Karakaya, Amanda N. Kallen

Reprod Sci. Author manuscript; available in PMC 2022 May 20.

Published in final edited form as: Reprod Sci. 2022 Apr; 29(4): 1357–1367. Published online 2021 Oct 15. doi: 10.1007/s43032-021-00700-5

PMCID:: PMC9120868

Abstract Article PDF–1021K

Select item 884885912.

P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency

Yilin Liu, Ilia G. Denisov, Yelena V. Grinkova, Stephen G. Sligar, James R. Kincaid

Chemistry. Author manuscript; available in PMC 2022 Feb 16.

Published in final edited form as: Chemistry. 2020 Dec 15; 26(70): 16846–16852. Published online 2020 Nov 9. doi: 10.1002/chem.202003181

PMCID:: PMC8848859

Abstract Article PDF–849K

Select item 882290213.

Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1

Yilin Liu, Yelena Grinkova, Michael C. Gregory, Ilia G. Denisov, James R. Kincaid, Stephen G. Sligar

Biochemistry. Author manuscript; available in PMC 2022 Nov 2.

Published in final edited form as: Biochemistry. 2021 Nov 2; 60(43): 3262–3271. Published online 2021 Oct 18. doi: 10.1021/acs.biochem.1c00282

PMCID:: PMC8822902

Abstract Article PDF–1.5M

Select item 835002014.

Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis

F. Peter Guengerich, Kevin D. McCarty, Jesse G. Chapman, Yasuhiro Tateishi

J Biol Chem. 2021 Aug; 297(2): 100969. Published online 2021 Jul 15. doi: 10.1016/j.jbc.2021.100969

PMCID:: PMC8350020

Abstract Article PDF–1.2M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808765516.

Steroidogenic Cytochrome P450 17A1 Structure and Function

Sarah D. Burris-Hiday, Emily E. Scott

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: Mol Cell Endocrinol. 2021 May 15; 528: 111261. Published online 2021 Mar 26. doi: 10.1016/j.mce.2021.111261

PMCID:: PMC8087655

Abstract Article PDF–1.6M

Select item 798049917.

Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students

Jing Zhang, Mengyi Yang, Pengfei Luan, Wei Jia, Qiujun Liu, Zhanbing Ma, Jie Dang, Hong Lu, Qian Ma, Yanfeng Wang, Chunlan Mu, Zhenghao Huo

Med Sci Monit. 2021; 27: e930591-1–e930591-13. Prepublished online 2021 Mar 3. Published online 2021 Mar 16. doi: 10.12659/MSM.930591

PMCID:: PMC7980499

Abstract Article PDF–1.8M

Select item 751800318.

Polymorphism in the Androgen Biosynthesis Gene (CYP17), a Risk for Prostate Cancer: A Meta-Analysis

Clement Yaw Effah, Ling Wang, Clement Agboyibor, Emmanuel Kwateng Drokow, Songcheng Yu, Wei Wang, Yongjun Wu

Am J Mens Health. 2020 Sep-Oct; 14(5): 1557988320959984. Published online 2020 Sep 23. doi: 10.1177/1557988320959984

PMCID:: PMC7518003

Abstract Article PDF–1.0M

Select item 751768219.

Exploration of CYP21A2 and CYP17A1 polymorphisms and preeclampsia risk among Chinese Han population: a large-scale case-control study based on 5021 subjects

Bo Hou, Xuewen Jia, Ziwen Deng, Xin Liu, Huitang Liu, Haichu Yu, Shiguo Liu

Hum Genomics. 2020; 14: 33. Published online 2020 Sep 25. doi: 10.1186/s40246-020-00286-0

PMCID:: PMC7517682

Abstract Article PDF–560K

Select item 746925220.

Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen

Eleanor Jing Yi Cheong, Pramod C. Nair, Rebecca Wan Yi Neo, Ho Thanh Tu, Fu Lin, Edmund Chiong, Kesavan Esuvaranathan, Hao Fan, Russell Z. Szmulewitz, Cody J. Peer, William D. Figg, Christina Li Lin Chai, John O. Miners, Eric Chun Yong Chan

J Pharmacol Exp Ther. 2020 Sep; 374(3): 438–451. Published online 2020 Sep. doi: 10.1124/jpet.120.265868

PMCID:: PMC7469252

Abstract Article PDF–1.2M

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