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Select item 107523751.

Fructose Induced KHK-C Can Increase ER Stress Independent of its Effect on Lipogenesis to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD

Se-Hyung Park, Robert N. Helsley, Taghreed Fadhul, Jennifer L.S. Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H. Solheim, Shiho Fujisaka, Hui Pan, Jonathan M. Dreyfuss, Joanna Bons, Jacob Rose, Christina D. King, Birgit Schilling, Aldons J. Lusis, Calvin Pan, Manoj Gupta, Rohit N. Kulkarni, Kevin Fitzgerald, Philip A. Kern, Senad Divanovic, C. Ronald Kahn, Samir Softic

Metabolism. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Metabolism. 2023 Aug; 145: 155591. Published online 2023 May 23. doi: 10.1016/j.metabol.2023.155591

PMCID:: PMC10752375

Abstract Article PDF–3.2M

Select item 81650302.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79017753.

Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants

Joseph A. Johnston, David R. Nelson, Pallav Bhatnagar, Sarah E. Curtis, Yu Chen, James G. MacKrell

PLoS One. 2021; 16(2): e0247683. Published online 2021 Feb 23. doi: 10.1371/journal.pone.0247683

PMCID:: PMC7901775

Abstract Article PDF–455K

Select item 75951124.

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer

Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, Jongmin Woo, Youngsoo Kim, June Huh, Jong-Wan Park

Nat Commun. 2020; 11: 5436. Published online 2020 Oct 28. doi: 10.1038/s41467-020-19263-1

PMCID:: PMC7595112

Abstract Article PDF–5.1M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67134756.

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne JG Chan, Samir Kharbanda, Jonathon J O'Brien, Fiona E McAllister, Ari J Firestone, Calvin H Jan, Jeffrey Settleman

eLife. 2019; 8: e47362. Published online 2019 Aug 27. doi: 10.7554/eLife.47362

PMCID:: PMC6713475

Abstract Article PDF–4.6M

Select item 64820127.

The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62

Daqian Xu, Xinjian Li, Fei Shao, Guishuai Lv, Hongwei Lv, Jong-Ho Lee, Xu Qian, Zheng Wang, Yan Xia, Linyong Du, Yanhua Zheng, Hongyang Wang, Jianxin Lyu, Zhimin Lu

Sci Adv. 2019 Apr; 5(4): eaav4570. Published online 2019 Apr 24. doi: 10.1126/sciadv.aav4570

PMCID:: PMC6482012

Abstract Article PDF–7.5M

Select item 56908668.

Genome-wide CRISPR screen for essential cell growth mediators in mutant KRAS colorectal cancers

Edwin H. Yau, Indrasena Reddy Kummetha, Gianluigi Lichinchi, Rachel Tang, Yunlin Zhang, Tariq M. Rana

Cancer Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Cancer Res. 2017 Nov 15; 77(22): 6330–6339. Published online 2017 Sep 27. doi: 10.1158/0008-5472.CAN-17-2043

PMCID:: PMC5690866

Abstract Article PDF–1.6M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 503652710.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 491389611.

Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase

MyPhuong T. Le, Miguel A. Lanaspa, Christina M. Cicerchi, Jatinder Rana, Jeffrey D. Scholten, Brandi L. Hunter, Christopher J. Rivard, R. Keith Randolph, Richard J. Johnson

PLoS One. 2016; 11(6): e0157458. Published online 2016 Jun 20. doi: 10.1371/journal.pone.0157458

PMCID:: PMC4913896

Abstract Article PDF–1.0M

Select item 488879412.

A splicing switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation

Xinjian Li, Xu Qian, Li-Xia Peng, Yuhui Jiang, David H. Hawke, Yanhua Zheng, Yan Xia, Jong-Ho Lee, Gilbert Cote, Hongxia Wang, Liwei Wang, Chao-Nan Qian, Zhimin Lu

Nat Cell Biol. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Nat Cell Biol. 2016 May; 18(5): 561–571. Published online 2016 Apr 18. doi: 10.1038/ncb3338

Correction in:: Nat Cell Biol. 2016 May 27; 18(6): 709.

PMCID:: PMC4888794

Abstract Article PDF–2.1M

Select item 478386913.

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

Peter Mirtschink, Jaya Krishnan, Fiona Grimm, Alexandre Sarre, Manuel Hörl, Melis Kayikci, Niklaus Fankhauser, Yann Christinat, Cédric Cortijo, Owen Feehan, Ana Vukolic, Samuel Sossalla, Sebastian N. Stehr, Jernej Ule, Nicola Zamboni, Thierry Pedrazzini, Wilhelm Krek

Nature. Author manuscript; available in PMC 2016 Mar 9.

Published in final edited form as: Nature. 2015 Jun 25; 522(7557): 444–449. Published online 2015 Jun 17. doi: 10.1038/nature14508

PMCID:: PMC4783869

Abstract Article PDF–5.0M

Select item 444121514.

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Nidhi Sahni, Song Yi, Mikko Taipale, Juan I. Fuxman Bass, Jasmin Coulombe-Huntington, Fan Yang, Jian Peng, Jochen Weile, Georgios I. Karras, Yang Wang, István A. Kovács, Atanas Kamburov, Irina Krykbaeva, Mandy H. Lam, George Tucker, Vikram Khurana, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Kourosh Salehi-Ashtiani, Luke J. Whitesell, Shamil Sunyaev, Bonnie Berger, Albert-László Barabási, Benoit Charloteaux, David E. Hill, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, Marc Vidal

Cell. Author manuscript; available in PMC 2016 Apr 23.

Published in final edited form as: Cell. 2015 Apr 23; 161(3): 647–660. doi: 10.1016/j.cell.2015.04.013

PMCID:: PMC4441215

Abstract Article PDF–1.2M

Select item 426658815.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 421452216.

Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

Miguel A. Lanaspa, Takuji Ishimoto, Christina Cicerchi, Yoshifuru Tamura, Carlos A. Roncal-Jimenez, Wei Chen, Katsuyuki Tanabe, Ana Andres-Hernando, David J. Orlicky, Esteban Finol, Shinichiro Inaba, Nanxing Li, Christopher J. Rivard, Tomoki Kosugi, Laura G. Sanchez-Lozada, J. Mark Petrash, Yuri Y. Sautin, A. Ahsan Ejaz, Wataru Kitagawa, Gabriela E. Garcia, David T. Bonthron, Aruna Asipu, Christine P. Diggle, Bernardo Rodriguez-Iturbe, Takahiko Nakagawa, Richard J. Johnson

J Am Soc Nephrol. 2014 Nov; 25(11): 2526–2538. Published online 2014 May 29. doi: 10.1681/ASN.2013080901

PMCID:: PMC4214522

Abstract Article

Select item 354485417.

Impact of Genetic Polymorphisms of SLC2A2, SLC2A5, and KHK on Metabolic Phenotypes in Hypertensive Individuals

MyPhuong T. Le, Maximilian T. Lobmeyer, Marcus Campbell, Jing Cheng, Zhiying Wang, Stephen T. Turner, Arlene B. Chapman, Eric Boerwinkle, John G. Gums, Yan Gong, Richard J. Johnson, Julie A. Johnson

PLoS One. 2013; 8(1): e52062. Published online 2013 Jan 14. doi: 10.1371/journal.pone.0052062

PMCID:: PMC3544854

Abstract Article PDF–240K

Select item 348044118.

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver

Miguel A. Lanaspa, Laura G. Sanchez-Lozada, Christina Cicerchi, Nanxing Li, Carlos A. Roncal-Jimenez, Takuji Ishimoto, Myphuong Le, Gabriela E. Garcia, Jeffrey B. Thomas, Christopher J. Rivard, Ana Andres-Hernando, Brandi Hunter, George Schreiner, Bernardo Rodriguez-Iturbe, Yuri Y. Sautin, Richard J. Johnson

PLoS One. 2012; 7(10): e47948. Published online 2012 Oct 24. doi: 10.1371/journal.pone.0047948

PMCID:: PMC3480441

Abstract Article PDF–1.2M

Select item 330669219.

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice

Takuji Ishimoto, Miguel A. Lanaspa, MyPhuong T. Le, Gabriela E. Garcia, Christine P. Diggle, Paul S. MacLean, Matthew R. Jackman, Aruna Asipu, Carlos A. Roncal-Jimenez, Tomoki Kosugi, Christopher J. Rivard, Shoichi Maruyama, Bernardo Rodriguez-Iturbe, Laura G. Sánchez-Lozada, David T. Bonthron, Yuri Y. Sautin, Richard J. Johnson

Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11): 4320–4325. Published online 2012 Feb 27. doi: 10.1073/pnas.1119908109

PMCID:: PMC3306692

Abstract Article PDF–1.0M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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