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Items: 1 to 20 of 53

1.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg
Science. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021
PMCID:
PMC10617673
AbstractArticlePDF–3.6M
2.
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB
Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan
EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698
PMCID:
PMC9433938
AbstractArticlePDF–9.3M
3.
Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs
Divya Ram Jayaram, Sigal Frost, Chanan Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Debra Toiber, Chen Keasar, Moshe Elkabets, Esti Yeger-Lotem, Etta Livneh
Proc Natl Acad Sci U S A. 2021 Oct 5; 118(40): e2018899118. Published online 2021 Sep 30. doi: 10.1073/pnas.2018899118
PMCID:
PMC8501901
AbstractArticlePDF–1.8M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
6.
PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia
Shaina N. Porter, Jeffrey A. Magee
Exp Hematol. Author manuscript; available in PMC 2019 Sep 6.
Published in final edited form as: Exp Hematol. 2017 Sep; 53: 43–47. Published online 2017 Jun 6. doi: 10.1016/j.exphem.2017.05.006
PMCID:
PMC6731097
AbstractArticlePDF–855K
7.
PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin
Cell Rep. Author manuscript; available in PMC 2019 Jun 26.
Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060
PMCID:
PMC6594551
AbstractArticlePDF–1.4M
8.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
9.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
10.
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
Javier Rodriguez, Ruth Pilkington, Amaya Garcia Munoz, Lan K. Nguyen, Nora Rauch, Susan Kennedy, Naser Monsefi, Ana Herrero, Cormac T. Taylor, Alex von Kriegsheim
Cell Rep. 2016 Mar 22; 14(11): 2745–2760. Published online 2016 Mar 10. doi: 10.1016/j.celrep.2016.02.043
PMCID:
PMC4805855
AbstractArticlePDF–4.6M
11.
Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes
Lídia Ambrus, Attila Oláh, Tamás Oláh, György Balla, Moin A. Saleem, Petronella Orosz, Judit Zsuga, Klára Bíró, László Csernoch, Tamás Bíró, Tamás Szabó
J Cell Mol Med. 2015 Dec; 19(12): 2771–2779. Published online 2015 Sep 25. doi: 10.1111/jcmm.12660
PMCID:
PMC4687697
AbstractArticlePDF–1.1M
12.
NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells
Nurdan Özkucur, Bing Song, Sharanya Bola, Lei Zhang, Brian Reid, Guo Fu, Richard H. W. Funk, Min Zhao
Cell Mol Life Sci. 2014 Dec; 71(23): 4653–4663. Published online 2014 May 1. doi: 10.1007/s00018-014-1632-1
PMCID:
PMC4437769
AbstractArticlePDF–1.6M
13.
A proteome-scale map of the human interactome network
Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal
Cell. Author manuscript; available in PMC 2015 Nov 20.
Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050
PMCID:
PMC4266588
AbstractArticlePDF–3.1M
14.
PKCη promotes senescence induced by oxidative stress and chemotherapy
U Zurgil, A Ben-Ari, K Atias, N Isakov, R Apte, E Livneh
Cell Death Dis. 2014 Nov; 5(11): e1531. Published online 2014 Nov 20. doi: 10.1038/cddis.2014.481
PMCID:
PMC4260739
AbstractArticlePDF–2.3M
15.
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
Eleanor Wheeler, Ni Huang, Elena Bochukova, Julia M. Keogh, Sarah Lindsay, Sumedha Garg, Elana Henning, Hannah Blackburn, Ruth J.F. Loos, Nick J Wareham, Stephen O’Rahilly, Matthew E. Hurles, Inês Barroso, I. Sadaf Farooqi
Nat Genet. Author manuscript; available in PMC 2014 Jul 22.
Published in final edited form as: Nat Genet. 2013 May; 45(5): 513–517. Published online 2013 Apr 7. doi: 10.1038/ng.2607
PMCID:
PMC4106235
ArticlePDF–756K
16.
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert R. Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua C. Denny, Robert J. Carroll, Anne E. Eyler, Jeffrey D. Greenberg, Joel M. Kremer, Dimitrios A. Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tõnu Esko, Andres Metspalu, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli A. Stahl, Dorothée Diogo, Jing Cui, Katherine Liao, Michael H. Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke J.H. Coenen, Piet L.C.M. van Riel, Mart A.F.J. van de Laar, Henk-Jan Guchelaar, Tom W.J. Huizinga, Philippe Dieudé, Xavier Mariette, S. Louis Bridges, Jr., Alexandra Zhernakova, Rene E.M. Toes, Paul P. Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Javier Martin, Miguel A. Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapää-Dahlqvist, Lisbeth Ärlestig, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, the RACI consortium, the GARNET consortium, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry W. Moreland, Lindsey A. Criswell, Elizabeth W. Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun S. Liu, Sang-Cheol Bae, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager, Lude Franke, Peter M. Visscher, Matthew A. Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Timothy W. Behrens, Katherine A. Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Robert M. Plenge
Nature. Author manuscript; available in PMC 2014 Aug 20.
Published in final edited form as: Nature. 2014 Feb 20; 506(7488): 376–381. Published online 2013 Dec 25. doi: 10.1038/nature12873
PMCID:
PMC3944098
AbstractArticlePDF–1.9M
17.
A genome-wide association study for reading and language abilities in two population cohorts
M Luciano, D M Evans, N K Hansell, S E Medland, G W Montgomery, N G Martin, M J Wright, T C Bates
Genes Brain Behav. 2013 Aug; 12(6): 645–652. Published online 2013 Jun 20. doi: 10.1111/gbb.12053
PMCID:
PMC3908370
AbstractArticlePDF–513K
18.
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist
Cell. Author manuscript; available in PMC 2014 Jan 17.
Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047
PMCID:
PMC3894786
AbstractArticlePDF–5.0M
19.
Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival
Deepanwita Pal, Shalini Persaud Outram, Alakananda Basu
Biochim Biophys Acta. Author manuscript; available in PMC 2014 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Aug; 1830(8): 4040–4045. Published online 2013 Apr 4. doi: 10.1016/j.bbagen.2013.03.028
PMCID:
PMC3697430
AbstractArticlePDF–2.1M
20.
PKCε regulates ATF2 availability to alter mitochondrial permeability following genotoxic stress
Eric Lau, Harriet Kluger, Tal Varsano, KiYoung Lee, Immo Scheffler, David L. Rimm, Trey Ideker, Ze’ev A. Ronai
Cell. Author manuscript; available in PMC 2013 Apr 3.
Published in final edited form as: Cell. 2012 Feb 3; 148(3): 543–555. doi: 10.1016/j.cell.2012.01.016
PMCID:
PMC3615433
AbstractArticlePDF–5.3M

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