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Select item 104008851.

Basonuclin-2 regulates extracellular matrix production and degradation

Ayla Orang, B Kate Dredge, Chi Yau Liu, Julie M Bracken, Chun-Hsien Chen, Laura Sourdin, Holly J Whitfield, Rachael Lumb, Sarah T Boyle, Melissa J Davis, Michael S Samuel, Philip A Gregory, Yeesim Khew-Goodall, Gregory J Goodall, Katherine A Pillman, Cameron P Bracken

Life Sci Alliance. 2023 Oct; 6(10): e202301984. Published online 2023 Aug 3. doi: 10.26508/lsa.202301984

PMCID:: PMC10400885

Abstract Article PDF–4.0M

Select item 94642132.

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute

Nat Commun. 2022; 13: 5324. Published online 2022 Sep 10. doi: 10.1038/s41467-022-33063-9

PMCID:: PMC9464213

Abstract Article PDF–3.6M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78231104.

Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome

Nadja Makki, Jingjing Zhao, Zhaoyang Liu, Walter L Eckalbar, Aki Ushiki, Anas M Khanshour, Joe Wu, Jonathan Rios, Ryan S Gray, Carol A Wise, Nadav Ahituv

Hum Mol Genet. 2020 Nov 15; 29(22): 3606–3615. Published online 2020 Nov 12. doi: 10.1093/hmg/ddaa242

PMCID:: PMC7823110

Abstract Article PDF–1.3M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 65068636.

Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction

Caroline M. Kolvenbach, Gabriel C. Dworschak, Sandra Frese, Anna S. Japp, Peggy Schuster, Nina Wenzlitschke, Öznur Yilmaz, Filipa M. Lopes, Alexey Pryalukhin, Luca Schierbaum, Loes F.M. van der Zanden, Franziska Kause, Ronen Schneider, Katarzyna Taranta-Janusz, Maria Szczepańska, Krzysztof Pawlaczyk, William G. Newman, Glenda M. Beaman, Helen M. Stuart, Raimondo M. Cervellione, Wouter F.J. Feitz, Iris A.L.M. van Rooij, Michiel F. Schreuder, Martijn Steffens, Stefanie Weber, Waltraut M. Merz, Markus Feldkötter, Bernd Hoppe, Holger Thiele, Janine Altmüller, Christoph Berg, Glen Kristiansen, Michael Ludwig, Heiko Reutter, Adrian S. Woolf, Friedhelm Hildebrandt, Phillip Grote, Marcin Zaniew, Benjamin Odermatt, Alina C. Hilger

Am J Hum Genet. 2019 May 2; 104(5): 994–1006. Published online 2019 May 2. doi: 10.1016/j.ajhg.2019.03.023

PMCID:: PMC6506863

Abstract Article PDF–2.5M

Select item 58568327.

An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis

Yoji Ogura, Kazuki Takeda, Ikuyo Kou, Anas Khanshour, Anna Grauers, Hang Zhou, Gang Liu, Yan-Hui Fan, Taifeng Zhou, Zhihong Wu, Yohei Takahashi, Morio Matsumoto, Japan Scoliosis Clinical Research Group (JSCRG), Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), Elisabet Einarsdottir, Juha Kere, Dongsheng Huang, Guixing Qiu, Leilei Xu, Yong Qiu, Carol A. Wise, You-Qiang Song, Nan Wu, Peiqiang Su, Paul Gerdhem, Kota Watanabe, Shiro Ikegawa

Sci Rep. 2018; 8: 4730. Published online 2018 Mar 16. doi: 10.1038/s41598-018-22552-x

PMCID:: PMC5856832

Abstract Article PDF–1.2M

Select item 58269268.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 505987710.

BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stress

Laura Cesaratto, Eleonora Grisard, Michela Coan, Luigi Zandonà, Elena De Mattia, Elena Poletto, Erika Cecchin, Fabio Puglisi, Vincenzo Canzonieri, Maria Teresa Mucignat, Antonella Zucchetto, Gabriele Stocco, Alfonso Colombatti, Milena S Nicoloso, Riccardo Spizzo

Cell Death Dis. 2016 Sep; 7(9): e2374. Published online 2016 Sep 22. doi: 10.1038/cddis.2016.278

Correction in:: Cell Death Dis. 2016 Dec; 7(12): e2526.

PMCID:: PMC5059877

Abstract Article PDF–1.1M

Select item 499354111.

BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein

Sadiya Malik, Hiroko Saito, Miho Takaoka, Yoshio Miki, Akira Nakanishi

Cell Cycle. 2016; 15(16): 2145–2156. Published online 2016 Jul 19. doi: 10.1080/15384101.2016.1195531

PMCID:: PMC4993541

Abstract Article PDF–1.6M

Select item 478388712.

Decreased Expression of BNC1 and BNC2 Is Associated with Genetic or Epigenetic Regulation in Hepatocellular Carcinoma

Yali Wu, Xiaolei Zhang, Yongzhen Liu, Fengmin Lu, Xiangmei Chen

Int J Mol Sci. 2016 Feb; 17(2): 153. Published online 2016 Jan 25. doi: 10.3390/ijms17020153

PMCID:: PMC4783887

Abstract Article PDF–1.4M

Select item 457326013.

A Functional SNP in BNC2 Is Associated with Adolescent Idiopathic Scoliosis

Yoji Ogura, Ikuyo Kou, Shigenori Miura, Atsushi Takahashi, Leilei Xu, Kazuki Takeda, Yohei Takahashi, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Ikuho Yonezawa, Haruhisa Yanagida, Hiroshi Taneichi, Zezhang Zhu, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Kota Watanabe, Naobumi Hosogane, Eijiro Okada, Aritoshi Iida, Masahiro Nakajima, Akihiro Sudo, Kazuhiro Chiba, Yuji Hiraki, Yoshiaki Toyama, Yong Qiu, Chisa Shukunami, Yoichiro Kamatani, Michiaki Kubo, Morio Matsumoto, Shiro Ikegawa

Am J Hum Genet. 2015 Aug 6; 97(2): 337–342. doi: 10.1016/j.ajhg.2015.06.012

PMCID:: PMC4573260

Abstract Article PDF–606K

Select item 407910714.

Genome-Wide Association Study of a Heart Failure-Related Metabolomic Profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study

Bing Yu, Yan Zheng, Danny Alexander, Teri A. Manolio, Alvaro Alonso, Jennifer A. Nettleton, Eric Boerwinkle

Genet Epidemiol. Author manuscript; available in PMC 2014 Jul 2.

Published in final edited form as: Genet Epidemiol. 2013 Dec; 37(8): 840–845. Published online 2013 Aug 11. doi: 10.1002/gepi.21752

PMCID:: PMC4079107

Abstract Article PDF–269K

Select item 407195715.

Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer

Stacey J. Winham, Sebastian M. Armasu, Mine S. Cicek, Melissa C. Larson, Julie M. Cunningham, Kimberly R. Kalli, Brooke L. Fridley, Ellen L. Goode

Genet Epidemiol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Genet Epidemiol. 2014 Jul; 38(5): 457–466. Published online 2014 May 22. doi: 10.1002/gepi.21815

PMCID:: PMC4071957

Abstract Article PDF–400K

Select item 325365816.

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

Shitao Li, Lingyan Wang, Michael Berman, Young-Yun Kong, Martin E. Dorf

Immunity. Author manuscript; available in PMC 2012 Sep 23.

Published in final edited form as: Immunity. 2011 Sep 23; 35(3): 426–440. Published online 2011 Sep 8. doi: 10.1016/j.immuni.2011.06.014

Correction in:: volume 35 on page 647

PMCID:: PMC3253658

Abstract Article PDF–4.2M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313128718.

Genetic Variation on 9p22 Is Associated with Abnormal Ovarian Ultrasound Results in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Nicolas Wentzensen, Amanda Black, Kevin Jacobs, Hannah P. Yang, Christine D. Berg, Neil Caporaso, Ulrike Peters, Lawrence Ragard, Saundra S. Buys, Stephen Chanock, Patricia Hartge

PLoS One. 2011; 6(7): e21731. Published online 2011 Jul 7. doi: 10.1371/journal.pone.0021731

PMCID:: PMC3131287

Abstract Article PDF–147K

Select item 308362419.

Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development

Elizabeth J Bhoj, Purita Ramos, Linda A Baker, Nicholas Cost, Agneta Nordenskjöld, Frederick F Elder, Steven B Bleyl, Neil E Bowles, Cammon B Arrington, Brigitte Delhomme, Amandine Vanhoutteghem, Philippe Djian, Andrew R Zinn

Eur J Hum Genet. 2011 May; 19(5): 540–546. Published online 2011 Feb 2. doi: 10.1038/ejhg.2010.245