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Items: 1 to 20 of 57

1.
The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress
Dylan F Fingerman, David R O’Leary, Ava R Hansen, Thi Tran, Brooke R Harris, Rachel A DeWeerd, Katharina E Hayer, Jiayi Fan, Emily Chen, Mithila Tennakoon, Alice Meroni, Julia H Szeto, Jessica Devenport, Danielle LaVigne, Matthew D Weitzman, Ophir Shalem, Jeffrey Bednarski, Alessandro Vindigni, Xiaolan Zhao, Abby M Green
EMBO J. 2024 Aug; 43(15): 3240–3255. Published online 2024 Jun 17. doi: 10.1038/s44318-024-00137-x
PMCID:
PMC11294446
AbstractArticlePDF–9.0M
2.
The SMC5/6 complex: folding chromosomes back into shape when genomes take a break
Shamayita Roy, Hemanta Adhikary, Damien D’Amours
Nucleic Acids Res. 2024 Mar 21; 52(5): 2112–2129. Published online 2024 Feb 20. doi: 10.1093/nar/gkae103
PMCID:
PMC10954462
AbstractArticlePDF–2.3M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120
PMCID:
PMC10151615
AbstractArticlePDF–2.9M
5.
The structural maintenance of chromosomes 5 is a possible biomarker for individualized treatment of colorectal cancer
Xiaoxia Gong, Xiaowei Tian, Hao Xie, Zhaoshui Li
Cancer Med. 2023 Feb; 12(3): 3276–3287. Published online 2022 Jul 27. doi: 10.1002/cam4.5074
PMCID:
PMC9939147
AbstractArticlePDF–2.9M
6.
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0
PMCID:
PMC9922468
AbstractArticlePDF–4.9M
7.
In‐frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance
Wenjiao Zhu, Yuanping Shi, Changrun Zhang, Yajie Peng, Yueyue Wan, Yue Xu, Xuemeng Liu, Bing Han, Shuangxia Zhao, Yanping Kuang, Huaidong Song, Jie Qiao
Clin Transl Med. 2023 Jan; 13(1): e1007. Published online 2023 Jan 10. doi: 10.1002/ctm2.1007
PMCID:
PMC9832215
AbstractArticlePDF–5.2M
8.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
9.
Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
Ishak D. Irwan, Hal P. Bogerd, Bryan R. Cullen
Nat Microbiol. 2022; 7(12): 2101–2113. Published online 2022 Nov 14. doi: 10.1038/s41564-022-01264-z
PMCID:
PMC9712108
AbstractArticlePDF–5.5M
10.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
11.
Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Nat Commun. 2022; 13: 6664. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34349-8
PMCID:
PMC9636423
AbstractArticlePDF–3.4M
12.
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation
Yulemi Gonzalez Quesada, Luc DesGroseillers
Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588
PMCID:
PMC9569955
AbstractArticlePDF–2.1M
13.
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y
PMCID:
PMC9343455
AbstractArticlePDF–3.7M
14.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
15.
Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening
Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C. E. Tosatto
Cancers (Basel) 2022 Feb; 14(4): 1009. Published online 2022 Feb 17. doi: 10.3390/cancers14041009
PMCID:
PMC8869832
AbstractArticlePDF–1.1M
16.
The Smc5/6 core complex is a structure-specific DNA binding and compacting machine
Diego Serrano, Gustavo Cordero, Ryo Kawamura, Aleksandr Sverzhinsky, Muzaddid Sarker, Shamayita Roy, Catherine Malo, John M. Pascal, John F. Marko, Damien D’Amours
Mol Cell. Author manuscript; available in PMC 2021 Dec 17.
Published in final edited form as: Mol Cell. 2020 Dec 17; 80(6): 1025–1038.e5. Published online 2020 Dec 9. doi: 10.1016/j.molcel.2020.11.011
PMCID:
PMC8224240
AbstractArticlePDF–2.5M
17.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
18.
The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
Liane Dupont, Stuart Bloor, James C. Williamson, Sergio Martínez Cuesta, Raven Shah, Ana Teixeira-Silva, Adi Naamati, Edward J.D. Greenwood, Stefan G. Sarafianos, Nicholas J. Matheson, Paul J. Lehner
Cell Host Microbe. 2021 May 12; 29(5): 792–805.e6. doi: 10.1016/j.chom.2021.03.001
PMCID:
PMC8118623
AbstractArticle
19.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
20.
N‐Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS‐CoV‐2 Main Protease
Tomas Koudelka, Juliane Boger, Alessandra Henkel, Robert Schönherr, Stefanie Krantz, Sabine Fuchs, Estefanía Rodríguez, Lars Redecke, Andreas Tholey
Proteomics. 2021 Jan; 21(2): 2000246. Published online 2020 Nov 17. doi: 10.1002/pmic.202000246
PMCID:
PMC7645863
AbstractArticlePDF–497K

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