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Select item 110374271.

Comparison of the Activation Kinetics of the M₃ Acetylcholine Receptor and a Constitutively Active Mutant Receptor in Living Cells

Carsten Hoffmann, Susanne Nuber, Ulrike Zabel, Nicole Ziegler, Christiane Winkler, Peter Hein, Catherine H. Berlot, Moritz Bünemann, Martin J. Lohse

Mol Pharmacol. 2012 Aug; 82(2): 236–245. doi: 10.1124/mol.112.077578

PMCID:: PMC11037427

Abstract Article PDF–950K

Select item 107950802.

Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults

Xi Zhang, Shi Yao, Peng Bao, Mingfei Du, Guilin Hu, Chao Chu, Dan Wang, Chen Chen, Qiong Ma, Hao Jia, Yue Sun, Yu Yan, Yueyuan Liao, Zejiaxin Niu, Ziyue Man, Lan Wang, Weihua Gao, Hao Li, Jie Zhang, Wenjing Luo, Xin Wang, Yang Wang, Jianjun Mu

J Clin Hypertens (Greenwich) 2024 Jan; 26(1): 36–46. Published online 2023 Nov 27. doi: 10.1111/jch.14753

PMCID:: PMC10795080

Abstract Article PDF–222K

Select item 101790053.

Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma—An Unexpected Correlation to Guide Future Treatment?

Leonard A. Lobbes, Marcel A. Schütze, Raoul Droeser, Marco Arndt, Ioannis Pozios, Johannes C. Lauscher, Nina A. Hering, Benjamin Weixler

Int J Mol Sci. 2023 May; 24(9): 8198. Published online 2023 May 3. doi: 10.3390/ijms24098198

PMCID:: PMC10179005

Abstract Article PDF–1.1M

Select item 101521544.

CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells

Çağdaş Aktan, Fatih Tekin, Nevin Oruç, Ömer Özütemiz

Turk J Gastroenterol. 2023 Mar; 34(3): 298–307. Published online 2023 Mar 1. doi: 10.5152/tjg.2022.22605

PMCID:: PMC10152154

Abstract Article PDF–1.2M

Select item 93737965.

Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands

Yiyu Wang, Jörg Scheffel, Carolina Ayala Vera, Wei Liu, Dorothee Günzel, Dorothea Terhorst-Molawi, Marcus Maurer, Sabine Altrichter

Front Immunol. 2022; 13: 955161. Published online 2022 Jul 29. doi: 10.3389/fimmu.2022.955161

PMCID:: PMC9373796

Abstract Article PDF–3.8M

Select item 92897156.

Expression of M3 muscarinic acetylcholine receptors in gastric cancer

Alina Maria Mehedinţeanu, Cecil Sorin Mirea, Puiu Olivian Stovicek, Michael Schenker, Marius Ionuţ Stancu, Ana-Maria Ciurea, Liliana Streba, Anca-Maria Istrate-Ofiţeru, Teodor-Nicuşor Sas, Cristin Constantin Vere

Rom J Morphol Embryol. 2021 Oct-Dec; 62(4): 1001–1010. Published online 2022 May 24. doi: 10.47162/RJME.62.4.12

PMCID:: PMC9289715

Abstract Article PDF–4.3M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 76708798.

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients

Silvia Jiménez-Morales, Juan Luis Jiménez-Ruíz, Blanca Estela Del Río-Navarro, Efraín Navarro-Olivos, Guillermo Escamilla-Guerrero, Ram Savan, Michael Dean, Lorena Orozco

Mol Biol Rep. Author manuscript; available in PMC 2020 Nov 17.

Published in final edited form as: Mol Biol Rep. 2014; 41(4): 2109–2117. Published online 2014 Jan 16. doi: 10.1007/s11033-014-3060-6

PMCID:: PMC7670879

Abstract Article PDF–468K

Select item 74550869.

M3 muscarinic acetylcholine receptor–reactive Th17 cells in primary Sjögren’s syndrome

Saori Abe, Hiroto Tsuboi, Hanae Kudo, Hiromitsu Asashima, Yuko Ono, Fumika Honda, Hiroyuki Takahashi, Mizuki Yagishita, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida

JCI Insight. 2020 Aug 6; 5(15): e135982. Published online 2020 Aug 6. doi: 10.1172/jci.insight.135982

PMCID:: PMC7455086

Abstract Article PDF–13M

Select item 742807610.

Muscarinic receptors promote castration resistant growth of prostate cancer through a FAK-YAP signaling axis

Yusuke Goto, Toshinori Ando, Hiroki Izumi, Xiaodong Feng, Nadia Arang, Mara Gilardi, Zhiyong Wang, Kazuyo Ando, J. Silvio Gutkind

Oncogene. Author manuscript; available in PMC 2020 Sep 23.

Published in final edited form as: Oncogene. 2020 May; 39(20): 4014–4027. Published online 2020 Mar 23. doi: 10.1038/s41388-020-1272-x

PMCID:: PMC7428076

Abstract Article PDF–1.0M

Select item 689947611.

A homozygous missense variant in CHRM3 associated with familial urinary bladder disease

Glenda M. Beaman, Gabriella Galatà, Keng W. Teik, Jill E. Urquhart, Ali Aishah, James O'Sullivan, Sanjeev S. Bhaskar, Katherine A. Wood, Huw B. Thomas, Raymond T. O'Keefe, Adrian S. Woolf, Helen M. Stuart, William G. Newman

Clin Genet. 2019 Dec; 96(6): 515–520. Published online 2019 Sep 11. doi: 10.1111/cge.13631

PMCID:: PMC6899476

Abstract Article PDF–1.3M

Select item 686124012.

A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans

Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter

Transl Psychiatry. 2019; 9: 309. Published online 2019 Nov 18. doi: 10.1038/s41398-019-0639-7

PMCID:: PMC6861240

Abstract Article PDF–767K

Select item 619383713.

M₃-subtype muscarinic receptor activation stimulates intracellular calcium oscillations and aldosterone production in human adrenocortical HAC15 cells

Latha M. Malaiyandi, Harsh Sharthiya, Nuntida Surachaicharn, Yara Shams, Mohammad Arshad, Chad Schupbach, Phillip G. Kopf, Kirk E. Dineley

Mol Cell Endocrinol. Author manuscript; available in PMC 2019 Dec 15.

Published in final edited form as: Mol Cell Endocrinol. 2018 Dec 15; 478: 1–9. Published online 2018 Jun 28. doi: 10.1016/j.mce.2018.06.016

PMCID:: PMC6193837

Abstract Article PDF–412K

Select item 607066314.

Muscarinic Receptor M₃R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells

R. Ross Welliver, Jessie J. Polanco, Richard A. Seidman, Anjali K. Sinha, Melanie A. O'Bara, Zainab M. Khaku, Diara A. Santiago González, Akiko Nishiyama, Jurgen Wess, M. Laura Feltri, Pablo M. Paez, Fraser J. Sim

J Neurosci. 2018 Aug 1; 38(31): 6921–6932. doi: 10.1523/JNEUROSCI.1862-17.2018

PMCID:: PMC6070663

Abstract Article PDF–3.8M

Select item 565006715.

Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells

Anan H. Said, Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, Jean-Pierre Raufman

Biochem J. Author manuscript; available in PMC 2018 Feb 20.

Published in final edited form as: Biochem J. 2017 Feb 20; 474(5): 647–665. Published online 2017 Feb 20. doi: 10.1042/BCJ20160704

PMCID:: PMC5650067

Abstract Article PDF–1.6M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522517.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 540056918.

Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis

Kunrong Cheng, Aaron C. Shang, Cinthia B. Drachenberg, Min Zhan, Jean-Pierre Raufman

Oncotarget. 2017 Mar 28; 8(13): 21106–21114. Published online 2017 Feb 18. doi: 10.18632/oncotarget.15500

PMCID:: PMC5400569

Abstract Article PDF–4.3M

Select item 537173019.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 534347920.

Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca²⁺ signaling in human retinal pigment epithelial cells

Rina Ikarashi, Honami Akechi, Yuzuki Kanda, Alsawaf Ahmad, Kouhei Takeuchi, Eri Morioka, Takashi Sugiyama, Takashi Ebisawa, Masaaki Ikeda, Masayuki Ikeda

Sci Rep. 2017; 7: 44175. Published online 2017 Mar 9. doi: 10.1038/srep44175

PMCID:: PMC5343479

Abstract Article PDF–2.0M

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