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Select item 111133111.

Glutamine deprivation initiates reversible assembly of mammalian rods and rings

S. John Calise, Wendy C. Carcamo, Claire Krueger, Joyce D. Yin, Daniel L. Purich, Edward K. L. Chan

Cell Mol Life Sci. 2014 Aug; 71(15): 2963–2973. Published online 2014 Jan 30. doi: 10.1007/s00018-014-1567-6

PMCID:: PMC11113311

Abstract Article PDF–1.4M

Select item 108384402.

Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

Yuting Huang, Szehoi Chan, Shuna Chen, Xueqi Liu, Miao Li, Liyuan Zheng, Zhaoxia Dong, Ziyi Yang, Zixuan Liu, Disheng Zhou, Xingding Zhang, Bo Zhang

J Transl Med. 2024; 22: 133. Published online 2024 Feb 3. doi: 10.1186/s12967-024-04934-0

PMCID:: PMC10838440

Abstract Article PDF–11M

Select item 107999033.

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun

Nat Commun. 2024; 15: 640. Published online 2024 Jan 20. doi: 10.1038/s41467-024-44958-0

PMCID:: PMC10799903

Abstract Article PDF–25M

Select item 104074314.

Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation

Audrey G. O’Neill, Anika L. Burrell, Michael Zech, Orly Elpeleg, Tamar Harel, Simon Edvardson, Hagar Mor-Shaked, Alyssa L. Rippert, Tomoki Nomakuchi, Kosuke Izumi, Justin M. Kollman

J Biol Chem. 2023 Aug; 299(8): 105012. Published online 2023 Jul 4. doi: 10.1016/j.jbc.2023.105012

PMCID:: PMC10407431

Abstract Article PDF–3.9M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516156.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 99504477.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 99501838.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 98519739.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 983242510.

c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming

Qiang Zhang, Kaisa Cui, Xiaoya Yang, Qilang He, Jing Yu, Li Yang, Gang Yao, Weiwei Guo, Zhanhao Luo, Yugeng Liu, Yuan Chen, Zhen He, Ping Lan

Clin Transl Med. 2023 Jan; 13(1): e1164. Published online 2023 Jan 11. doi: 10.1002/ctm2.1164

PMCID:: PMC9832425

Abstract Article PDF–5.4M

Select item 976969811.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 959735212.

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

Shalini Rawat, Dhruba Chatterjee, Rituraj Marwaha, Gitanjali Charak, Gaurav Kumar, Shrestha Shaw, Divya Khatter, Sheetal Sharma, Cecilia de Heus, Nalan Liv, Judith Klumperman, Amit Tuli, Mahak Sharma

J Cell Biol. 2023 Jan 2; 222(1): e202108001. Published online 2022 Oct 25. doi: 10.1083/jcb.202108001

PMCID:: PMC9597352

Abstract Article PDF–12M

Select item 953348613.

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong, Bo Xiang

Mol Cancer. 2022; 21: 192. Published online 2022 Oct 5. doi: 10.1186/s12943-022-01659-w

PMCID:: PMC9533486

Abstract Article PDF–12M

Select item 952399714.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 952364515.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 951337416.

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling

Tai-Wei Li, Adam D. Kenney, Jun-Gyu Park, Guillaume N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty Santoso, Luis Martinez-Sobrido, Jacob S. Yount, Jian Zhu

Front Immunol. 2022; 13: 1007089. Published online 2022 Sep 13. doi: 10.3389/fimmu.2022.1007089

PMCID:: PMC9513374

Abstract Article PDF–6.1M

Select item 949923817.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Marius Walter, Irene P. Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L. Lam, Jennifer M. Hayashi, Andrew Cruz, Samah Shah, Frank W. Soveg, John D. Gross, Nevan J. Krogan, Keith R. Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

PLoS Pathog. 2022 Sep; 18(9): e1010811. Published online 2022 Sep 12. doi: 10.1371/journal.ppat.1010811

PMCID:: PMC9499238

Abstract Article PDF–3.7M

Select item 948193318.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 944065319.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 934345520.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

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