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Select item 97849401.

The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain

Maike Stegen, Ulrich H. Frey

Int J Mol Sci. 2022 Dec; 23(24): 15880. Published online 2022 Dec 14. doi: 10.3390/ijms232415880

PMCID:: PMC9784940

Abstract Article PDF–1.6M

Select item 92626142.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 89515563.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80421745.

Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport

Maria Vistrup-Parry, W. Bruce Sneddon, Sofie Bach, Kristian Strømgaard, Peter A. Friedman, Tatyana Mamonova

J Biol Chem. 2021 Jan-Jun; 296: 100473. Published online 2021 Feb 24. doi: 10.1016/j.jbc.2021.100473

PMCID:: PMC8042174

Abstract Article PDF–1.4M

Select item 78917176.

Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site

Maike Stegen, Andrea Engler, Crista Ochsenfarth, Iris Manthey, Jürgen Peters, Winfried Siffert, Ulrich H. Frey

PLoS One. 2021; 16(2): e0247087. Published online 2021 Feb 18. doi: 10.1371/journal.pone.0247087

PMCID:: PMC7891717

Abstract Article PDF–2.6M

Select item 74273277.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 71882908.

S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease

Weiwei Wu, Chun Chau Sung, Peichun Yu, Jiahua Li, Kenny K. K. Chung

PLoS One. 2020; 15(4): e0232019. Published online 2020 Apr 28. doi: 10.1371/journal.pone.0232019

Correction in:: PLoS One. 2020; 15(6): e0235296.

PMCID:: PMC7188290

Abstract Article PDF–3.1M

Select item 64438619.

Hypermethylation of the G protein‐coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells

Sumei Yao, Dandan Wu, Jinliang Chen, Peng Wang, Xuedong Lv, Jianan Huang

FEBS Open Bio. 2019 Apr; 9(4): 605–617. Published online 2019 Mar 19. doi: 10.1002/2211-5463.12606

PMCID:: PMC6443861

Abstract Article PDF–1.5M

Select item 612890510.

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Hema Adhikari, Christopher M. Counter

Nat Commun. 2018; 9: 3646. Published online 2018 Sep 7. doi: 10.1038/s41467-018-05692-6

PMCID:: PMC6128905

Abstract Article PDF–2.2M

Select item 600136711.

Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma

Xiaoqi Che, Guihui Zhang, Xiaojing Zhang, Jie Xue

Med Sci Monit. 2018; 24: 3540–3548. Published online 2018 May 28. doi: 10.12659/MSM.908176

PMCID:: PMC6001367

Abstract Article PDF–1003K

Select item 558125412.

The association of single nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes

Chad A GROTEGUT, Ms Emily NGAN, Ms Melanie E GARRETT, Marie Lynn MIRANDA, Allison E ASHLEY-KOCH, Geeta K SWAMY

Am J Obstet Gynecol. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Am J Obstet Gynecol. 2017 Sep; 217(3): 367.e1–367.e9. Published online 2017 May 17. doi: 10.1016/j.ajog.2017.05.023

PMCID:: PMC5581254

Abstract Article PDF–695K

Select item 555224113.

c-Src, Insulin-like growth factor I receptor, G-protein-coupled Receptor Kinases and Focal Adhesion Kinase are enriched into Prostate Cancer Cell Exosomes

Rachel M. DeRita, Brad Zerlanko, Amrita Singh, Huimin Lu, Renato V. Iozzo, Jeffrey L. Benovic, Lucia R. Languino

J Cell Biochem. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: J Cell Biochem. 2017 Jan; 118(1): 66–73. Published online 2016 Jul 12. doi: 10.1002/jcb.25611

PMCID:: PMC5552241

Abstract Article PDF–798K

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 541918415.

Regulation of Oxytocin Receptor Responsiveness by G Protein-Coupled Receptor Kinase 6 in Human Myometrial Smooth Muscle

Jonathon M. Willets, Paul J. Brighton, Rajendra Mistry, Gavin E. Morris, Justin C. Konje, R. A. John Challiss

Mol Endocrinol. August 1, 2009; 23(8): 1272–1280. doi: 10.1210/me.2009-0047

PMCID:: PMC5419184

Abstract Article

Select item 526093916.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 526090417.

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal

Qiumin Le, Wenqing Yao, Yuejun Chen, Biao Yan, Cao Liu, Man Yuan, Yuqing Zhou, Lan Ma

Cell Death Dis. 2016 Nov; 7(11): e2478. Published online 2016 Nov 24. doi: 10.1038/cddis.2016.377

PMCID:: PMC5260904

Abstract Article PDF–1.1M

Select item 461721118.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 404523519.

Identifying biological pathways that underlie primordial short stature using network analysis

Dan Hanson, Adam Stevens, Philip G Murray, Graeme C M Black, Peter E Clayton

J Mol Endocrinol. 2014 Jun; 52(3): 333–344. Prepublished online 2014 Apr 7. doi: 10.1530/JME-14-0029

PMCID:: PMC4045235

Abstract Article PDF–663K

Select item 395990220.

Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail

Rebecca N. Burns, Monalisa Singh, Ilya S. Senatorov, Nader H. Moniri

Biochem Pharmacol. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: Biochem Pharmacol. 2014 Feb 15; 87(4): 650–659. Published online 2014 Jan 8. doi: 10.1016/j.bcp.2013.12.016

PMCID:: PMC3959902

Abstract Article PDF–1.3M

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