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Items: 1 to 20 of 77

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
WNT signalling control by KDM5C during development affects cognition
Violetta Karwacki-Neisius, Ahram Jang, Engin Cukuroglu, Albert Tai, Alan Jiao, Danilo Predes, Joon Yoon, Emily Brookes, Jiekai Chen, Aimee Iberg, Florian Halbritter, Katrin Õunap, Jozef Gecz, Thorsten M. Schlaeger, Shannan Ho Sui, Jonathan Göke, Xi He, Maria K. Lehtinen, Scott L. Pomeroy, Yang Shi
Nature. 2024; 627(8004): 594–603. Published online 2024 Feb 21. doi: 10.1038/s41586-024-07067-y
PMCID:
PMC10954547
AbstractArticlePDF–27M
3.
Comparative interactome analysis of α-arrestin families in human and Drosophila
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam
eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328
PMCID:
PMC10945707
AbstractArticlePDF–2.8M
4.
Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression
Fulong Yu, Liang Li, Yimei Gu, Song Wang, Lianbang Zhou, Xiaohu Cheng, Heng Jiang, Yang Huang, Yingfeng Zhang, Wenbao Qian, Xianghua Li, Zhining Liu
Mol Med. 2024; 30: 9. Published online 2024 Jan 12. doi: 10.1186/s10020-023-00775-7
PMCID:
PMC10785505
AbstractArticlePDF–8.9M
5.
KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas
Dan Wang, Yingjun Zhang, Zhouning Liao, Heming Ge, Cenap Güngör, Yuqiang Li
Sci Rep. 2023; 13: 18250. Published online 2023 Oct 25. doi: 10.1038/s41598-023-44536-2
PMCID:
PMC10600175
AbstractArticlePDF–5.5M
6.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
7.
Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations
Fatima S. Ugur, Mark J. S. Kelly, Danica Galonić Fujimori
J Mol Biol. Author manuscript; available in PMC 2023 Jun 7.
Published in final edited form as: J Mol Biol. 2023 Jan 30; 435(2): 167913. Published online 2022 Dec 7. doi: 10.1016/j.jmb.2022.167913
PMCID:
PMC10247153
AbstractArticlePDF–2.1M
8.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
9.
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy
BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4
PMCID:
PMC10080908
AbstractArticlePDF–3.2M
10.
The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts
Huadie Liu, Lukai Zhai, Ye Liu, Di Lu, Alexandra Vander Ark, Tao Yang, Connie M. Krawczyk
Sci Adv. 2023 Apr; 9(14): eadg0731. Published online 2023 Apr 5. doi: 10.1126/sciadv.adg0731
PMCID:
PMC10075994
AbstractArticlePDF–2.2M
11.
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir, Mafalda Araujo Pereira, Adrija Kalvisa, Marta Tapia, Jinyu Su, Ying Ge, Bauke de Boer, Alexander Balhuizen, Frederik Otzen Bagger, Pavel Shliaha, Patrycja Sroczynska, Julian Walfridsson, Kirsten Grønbæk, Kim Theilgaard-Mönch, Ole N. Jensen, Kristian Helin, Bo T. Porse
Leukemia. 2023; 37(3): 593–605. Published online 2023 Jan 12. doi: 10.1038/s41375-023-01810-6
PMCID:
PMC9991918
AbstractArticlePDF–2.4M
12.
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0
PMCID:
PMC9922468
AbstractArticlePDF–4.9M
13.
Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants
Emanuela Leonardi, Maria Cristina Aspromonte, Denise Drongitis, Elisa Bettella, Lucia Verrillo, Roberta Polli, Meriel McEntagart, Laura Licchetta, Robertino Dilena, Stefano D’Arrigo, Claudia Ciaccio, Silvia Esposito, Vincenzo Leuzzi, Annalaura Torella, Demetrio Baldo, Fortunato Lonardo, Giulia Bonato, Serena Pellegrin, Franco Stanzial, Renata Posmyk, Ewa Kaczorowska, Miryam Carecchio, Monika Gos, Sylwia Rzońca-Niewczas, Maria Giuseppina Miano, Alessandra Murgia
Eur J Hum Genet. 2023 Feb; 31(2): 202–215. Published online 2022 Nov 25. doi: 10.1038/s41431-022-01233-4
PMCID:
PMC9905063
AbstractArticlePDF–1.5M
14.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
15.
Regulation of KDM5C stability and enhancer reprogramming in breast cancer
Qiong Xiao, Chen-Yu Wang, Chuan Gao, Ji-Dong Chen, Jing-Jing Chen, Zhen Wang, Lin-Gao Ju, Shan-Bo Tang, Jie Yao, Feng Li, Lian-Yun Li, Min Wu
Cell Death Dis. 2022 Oct; 13(10): 843. Published online 2022 Oct 3. doi: 10.1038/s41419-022-05296-5
PMCID:
PMC9530161
AbstractArticlePDF–5.9M
16.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
17.
Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7
Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang, Huan-Ping Wang
Bioengineered. 2022; 13(4): 8538–8547. Published online 2022 Mar 24. doi: 10.1080/21655979.2022.2051840
PMCID:
PMC9161961
AbstractArticlePDF–1.1M
18.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
19.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
20.
HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression
YuYing Cui, Chao LV, Yu Wen, Dongmei Zhao, Yu Yang, Hongbin Qiu, Chennan Wang
Balkan Med J. 2022 Jan; 39(1): 30–38. Published online 2022 Jan 25. doi: 10.5152/balkanmedj.2021.21068
PMCID:
PMC8941240
AbstractArticlePDF–4.3M

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