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Select item 109428651.

CRL4^DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication

Josina Grossmann, Anne-Sophie Kratz, Alina Kordonsky, Gali Prag, Ingrid Hoffmann

Life Sci Alliance. 2024 Jun; 7(6): e202402668. Published online 2024 Mar 15. doi: 10.26508/lsa.202402668

PMCID:: PMC10942865

Abstract Article PDF–3.4M

Select item 108698002.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 105413133.

PLK4 self-phosphorylation drives the selection of a single site for procentriole assembly

Phillip Scott, Ana Curinha, Colin Gliech, Andrew J. Holland

J Cell Biol. 2023 Dec 4; 222(12): e202301069. Published online 2023 Sep 29. doi: 10.1083/jcb.202301069

Correction in:: J Cell Biol. 2024 Jan 1; 223(1): e20230106912112023c.

PMCID:: PMC10541313

Abstract Article PDF–7.7M

Select item 105014434.

Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning

Catherine Sullenberger, Dong Kong, Pegah Avazpour, Delgermaa Luvsanjav, Jadranka Loncarek

J Cell Biol. 2023 Dec 4; 222(12): e202301092. Published online 2023 Sep 14. doi: 10.1083/jcb.202301092

PMCID:: PMC10501443

Abstract Article PDF–6.8M

Select item 103360055.

Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells

Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee

Commun Biol. 2023; 6: 712. Published online 2023 Jul 11. doi: 10.1038/s42003-023-05067-8

Correction in:: Commun Biol. 2023; 6: 784.

PMCID:: PMC10336005

Abstract Article PDF–6.1M

Select item 103239016.

NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4

Declan Whyte, George Skalka, Peter Walsh, Ania Wilczynska, Nikki R. Paul, Claire Mitchell, Colin Nixon, William Clarke, Martin Bushell, Jennifer P. Morton, Daniel J. Murphy, Nathiya Muthalagu

Mol Oncol. 2023 Jul; 17(7): 1212–1227. Published online 2023 Apr 3. doi: 10.1002/1878-0261.13425

PMCID:: PMC10323901

Abstract Article PDF–2.5M

Select item 101154937.

Polo-like Kinase 4: the Variation During Therapy and its Relation to Treatment Response and Prognostic Risk Stratification in Childhood Acute Lymphoblastic Leukemia Patients

Junfang Xu, Liping Zhao

J Pediatr Hematol Oncol. 2023 May; 45(4): 189–194. Published online 2022 Aug 11. doi: 10.1097/MPH.0000000000002520

PMCID:: PMC10115493

Abstract Article PDF–357K

Select item 100729068.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99359219.

Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

Irina Fonseca, Cíntia Horta, Ana Sofia Ribeiro, Barbara Sousa, Gaëlle Marteil, Mónica Bettencourt-Dias, Joana Paredes

Cell Death Dis. 2023 Feb; 14(2): 133. Published online 2023 Feb 16. doi: 10.1038/s41419-023-05618-1

PMCID:: PMC9935921

Abstract Article PDF–3.1M

Select item 955637210.

Transmission ratio distortion of mutations in the master regulator of centriole biogenesis PLK4

Heidemarie Neitzel, Raymonda Varon, Sana Chughtai, Josephine Dartsch, Véronique Dutrannoy-Tönsing, Peter Nürnberg, Gudrun Nürnberg, Michal Schweiger, Martin Digweed, Gabriele Hildebrand, Karl Hackmann, Manuel Holtgrewe, Nanette Sarioglu, Bernt Schulze, Denise Horn, Karl Sperling

Hum Genet. 2022; 141(11): 1785–1794. Published online 2022 May 10. doi: 10.1007/s00439-022-02461-w

PMCID:: PMC9556372

Abstract Article PDF–1.8M

Select item 925104911.

Downregulation of PLK4 expression induces apoptosis and G0/G1‐phase cell cycle arrest in keloid fibroblasts

Ru‐Lin Huang, Chuanqi Liu, Rao Fu, Yuxin Yan, Jing Yang, Xinggang Wang, Qingfeng Li

Cell Prolif. 2022 Jul; 55(7): e13271. Published online 2022 Jun 7. doi: 10.1111/cpr.13271

PMCID:: PMC9251049

Abstract Article PDF–13M

Select item 911973612.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 909099613.

PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence

Chandra K. Singh, Ryan A. Denu, Minakshi Nihal, Maria Shabbir, Debra R. Garvey, Wei Huang, Kenneth A. Iczkowski, Nihal Ahmad

Prostate. 2022 Jun 15; 82(9): 957–969. Published online 2022 Mar 25. doi: 10.1002/pros.24342

PMCID:: PMC9090996

Abstract Article PDF–3.5M

Select item 898350514.

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4

Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S. Toss, Mohammed Aleskandarany, Emiel A. Janssen, Håvard Søiland, Meenakshi. V. Gupta, Michelle D. Reid, Emad A. Rakha, Ritu Aneja

Mol Cancer Res. 2022 Apr 1; 20(4): 596–606. Published online 2021 Dec 21. doi: 10.1158/1541-7786.MCR-20-0798

PMCID:: PMC8983505

Abstract Article PDF–2.2M

Select item 840930015.

Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Ziyi Yang, Haiyan Sun, Wenlong Ma, Kai Wu, Guoyu Peng, Tong Ou, Song Wu

FEBS Open Bio. 2021 Sep; 11(9): 2631–2646. Published online 2021 Aug 22. doi: 10.1002/2211-5463.13262

PMCID:: PMC8409300

Abstract Article PDF–3.1M

Select item 835296416.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 827812317.

Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile

Sisi Deng, Xiaoli Lu, Zhi Zhang, Rui Meng, Mi Li, Shilin Xia

J Cell Mol Med. 2021 Jul; 25(14): 6652–6663. Published online 2021 Jun 2. doi: 10.1111/jcmm.16668

PMCID:: PMC8278123

Abstract Article PDF–2.2M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 802652519.

Role of polo-like kinase 4 (PLK4) in epithelial cancers and recent progress in its small molecule targeting for cancer management

Debra R. Garvey, Gagan Chhabra, Mary A. Ndiaye, Nihal Ahmad

Mol Cancer Ther. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cancer Ther. 2021 Apr; 20(4): 632–640. Published online 2021 Jan 5. doi: 10.1158/1535-7163.MCT-20-0741

PMCID:: PMC8026525

Abstract Article PDF–814K

Select item 792718020.

Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis

Roberta Sala, KC Farrell, Tim Stearns

Mol Biol Cell. 2020 Nov 15; 31(24): 2646–2656. doi: 10.1091/mbc.E19-04-0195

PMCID:: PMC7927180

Abstract Article PDF–2.0M

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