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Items: 1 to 20 of 167

1.
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel‐induced leukopenia
Kazuma Kiyotani, Taisei Mushiroda, Michiaki Kubo, Hitoshi Zembutsu, Yuichi Sugiyama, Yusuke Nakamura
Cancer Sci. 2008 May; 99(5): 967–972. Published online 2008 Feb 20. doi: 10.1111/j.1349-7006.2008.00765.x
PMCID:
PMC11159748
AbstractArticlePDF–101K
2.
Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2
Yong Zhang, Guoyu Yu, Yanjie Wang, Yang Xiang, Qian Gao, Ping Jiang, Jie Zhang, Wenhui Lee, Yun Zhang
Cell Mol Life Sci. 2011 Nov; 68(22): 3771–3780. Published online 2011 Apr 3. doi: 10.1007/s00018-011-0678-6
PMCID:
PMC11115081
AbstractArticlePDF–2.2M
3.
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
Moumita Dutta, Joe Jongpyo Lim, Julia Yue Cui
Drug Metab Dispos. 2022 Apr; 50(4): 478–491. Published online 2022 Apr. doi: 10.1124/dmd.121.000415
PMCID:
PMC11022899
AbstractArticlePDF–424K
4.
St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism
Tingting Yan, Yuhong Luo, Yangliu Xia, Keisuke Hamada, Qiong Wang, Nana Yan, Kristopher W. Krausz, Jerrold M. Ward, Haiping Hao, Ping Wang, Frank J. Gonzalez
FASEB J. Author manuscript; available in PMC 2023 May 9.
Published in final edited form as: FASEB J. 2021 Nov; 35(11): e21968. doi: 10.1096/fj.202001098R
PMCID:
PMC10167919
AbstractArticlePDF–2.7M
5.
Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients
Hironobu Yagishita, Hideaki Kagaya, Mitsuru Saito, Kazuyuki Numakura, Ryohei Yamamoto, Ryuichiro Sagehashi, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura
Int J Mol Sci. 2022 Oct; 23(19): 11742. Published online 2022 Oct 3. doi: 10.3390/ijms231911742
PMCID:
PMC9570057
AbstractArticlePDF–510K
6.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
7.
Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age
Wei Li, Ehab Osman, Claes Forssell, Xi-Ming Yuan
Int J Mol Sci. 2022 Jun; 23(12): 6363. Published online 2022 Jun 7. doi: 10.3390/ijms23126363
PMCID:
PMC9223560
AbstractArticlePDF–1.2M
8.
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen
Nucleic Acids Res. 2022 Apr 8; 50(6): 3254–3275. Published online 2022 Feb 25. doi: 10.1093/nar/gkac133
PMCID:
PMC8989523
AbstractArticlePDF–2.8M
9.
Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3
Xiaxia Niu, Hongmei Cui, Xinsheng Gu, Ting Wu, Min Sun, Changlong Zhou, Mei Ma
Front Oncol. 2022; 12: 837980. Published online 2022 Mar 16. doi: 10.3389/fonc.2022.837980
PMCID:
PMC8965888
AbstractArticlePDF–5.4M
10.
The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance Gq/Gi Signaling
Qiu-Yan Xu, Yong-Jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang
Front Immunol. 2022; 13: 818151. Published online 2022 Feb 28. doi: 10.3389/fimmu.2022.818151
PMCID:
PMC8918515
AbstractArticlePDF–3.7M
11.
Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
Mikko Karpale, Janne Hukkanen, Jukka Hakkola
Cells. 2022 Feb; 11(3): 313. Published online 2022 Jan 18. doi: 10.3390/cells11030313
PMCID:
PMC8833906
AbstractArticlePDF–892K
12.
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis
Mengyao Qin, Yu Xin, Yong Bian, Xuan Yang, Tao Xi, Jing Xiong
Cells. 2022 Jan; 11(2): 264. Published online 2022 Jan 13. doi: 10.3390/cells11020264
PMCID:
PMC8773821
AbstractArticlePDF–3.2M
13.
PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
Cells. 2021 Dec; 10(12): 3550. Published online 2021 Dec 16. doi: 10.3390/cells10123550
PMCID:
PMC8700377
AbstractArticlePDF–2.5M
14.
Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation
Julian Friebel, Eileen Moritz, Marco Witkowski, Kai Jakobs, Elisabeth Strässler, Andrea Dörner, Daniel Steffens, Marianna Puccini, Stella Lammel, Rainer Glauben, Franziska Nowak, Nicolle Kränkel, Arash Haghikia, Verena Moos, Heinz-Peter Schutheiss, Stephan B. Felix, Ulf Landmesser, Bernhard H. Rauch, Ursula Rauch
Cells. 2021 Dec; 10(12): 3517. Published online 2021 Dec 13. doi: 10.3390/cells10123517
PMCID:
PMC8700178
AbstractArticlePDF–5.8M
15.
Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment
Aikaterini Skandalaki, Panagiotis Sarantis, Stamatios Theocharis
Biomolecules. 2021 Aug; 11(8): 1142. Published online 2021 Aug 2. doi: 10.3390/biom11081142
PMCID:
PMC8394562
AbstractArticlePDF–1.4M
16.
High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct
Venkateswara R. Gogulamudi, Danielle Y. Arita, Camille R. T. Bourgeois, Justine Jorgensen, Jing He, William C. Wimley, Ryosuke Satou, Alexis A. Gonzalez, Minolfa C. Prieto
Sci Rep. 2021; 11: 13815. Published online 2021 Jul 5. doi: 10.1038/s41598-021-93296-4
PMCID:
PMC8257763
AbstractArticlePDF–3.3M
17.
B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation
Cinzia Giagulli, Francesca Caccuri, Simone Zorzan, Antonella Bugatti, Alberto Zani, Federica Filippini, Ekta Manocha, Pasqualina D’Ursi, Alessandro Orro, Riccardo Dolcetti, Arnaldo Caruso
Cancer Gene Ther. 2021; 28(6): 649–666. Published online 2020 Oct 22. doi: 10.1038/s41417-020-00246-9
PMCID:
PMC8203498
AbstractArticlePDF–2.3M
18.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
19.
Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis
Hanze Guo, Yan Chi, Naiyu Chi
Sci Rep. 2021; 11: 5428. Published online 2021 Mar 8. doi: 10.1038/s41598-021-83742-8
PMCID:
PMC7940411
AbstractArticlePDF–2.0M
20.
Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
Vanessa Delfosse, Tiphaine Huet, Deborah Harrus, Meritxell Granell, Maxime Bourguet, Caroline Gardia-Parège, Barbara Chiavarina, Marina Grimaldi, Sébastien Le Mével, Pauline Blanc, David Huang, Jakub Gruszczyk, Barbara Demeneix, Sarah Cianférani, Jean-Baptiste Fini, Patrick Balaguer, William Bourguet
Proc Natl Acad Sci U S A. 2021 Jan 5; 118(1): e2020551118. Published online 2020 Dec 28. doi: 10.1073/pnas.2020551118
PMCID:
PMC7817120
AbstractArticlePDF–2.0M

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