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Select item 106438901.

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19

Maximilian Peter Götz, Mikkel-Ole Skjoedt, Rafael Bayarri-Olmos, Cecilie Bo Hansen, Laura Pérez-Alós, Ida Jarlhelt, Thomas Benfield, Anne Rosbjerg, Peter Garred

J Innate Immun. 2023 Jan-Dec; 15(1): 122–135. Published online 2022 Jul 11. doi: 10.1159/000525508

PMCID:: PMC10643890

Abstract Article PDF–577K

Select item 103617442.

MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence

Sonia Elhadad, David Redmond, Jenny Huang, Adrian Tan, Jeffrey Laurence

Clin Exp Immunol. 2023 Aug; 213(2): 252–264. Published online 2023 May 16. doi: 10.1093/cei/uxad055

PMCID:: PMC10361744

Abstract Article PDF–999K

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101963104.

Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India)

Sadhana Sharma, Bandana Kumari, Asgar Ali, Pankaj Kumar Patel, Abhay Kumar Sharma, Rathish Nair, Prabhat Kumar Singh, Krishnan Hajela

Mol Genet Genomics. 2023; 298(4): 955–963. Published online 2023 May 18. doi: 10.1007/s00438-023-02030-4

PMCID:: PMC10196310

Abstract Article PDF–839K

Select item 95093615.

Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel

Rikke Zachar, Steffen Thiel, Søren Hansen, Maiken Lumby Henriksen, Mikkel-Ole Skjoedt, Karsten Skjodt, Zohra Hamzaei, Kirsten Madsen, Lars Lund, Edith Hummler, Per Svenningsen, Boye Lagerbon Jensen

Sci Rep. 2022; 12: 15955. Published online 2022 Sep 24. doi: 10.1038/s41598-022-20213-8

PMCID:: PMC9509361

Abstract Article PDF–2.0M

Select item 94706756.

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Ting Gao, Lin Zhu, Hainan Liu, Xiaopeng Zhang, Tingting Wang, Yangbo Fu, Hongzhen Li, Qincai Dong, Yong Hu, Zhang Zhang, Jing Jin, Zijing Liu, Weihong Yang, Yaoning Liu, Yanwen Jin, Kaitong Li, Yongjiu Xiao, Junli Liu, Huailong Zhao, Yue Liu, Ping Li, Jibo Song, Lu Zhang, Yuwei Gao, Sisi Kang, Shoudeng Chen, Qingjun Ma, Xiuwu Bian, Wei Chen, Xuan Liu, Qing Mao, Cheng Cao

Signal Transduct Target Ther. 2022; 7: 318. Published online 2022 Sep 14. doi: 10.1038/s41392-022-01133-5

PMCID:: PMC9470675

Abstract Article PDF–6.1M

Select item 91361297.

Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation

Zoltán Attila Nagy, Dávid Héja, Dániel Bencze, Bence Kiss, Eszter Boros, Dávid Szakács, Krisztián Fodor, Matthias Wilmanns, Andrea Kocsis, József Dobó, Péter Gál, Veronika Harmat, Gábor Pál

J Biol Chem. 2022 Jun; 298(6): 101985. Published online 2022 Apr 25. doi: 10.1016/j.jbc.2022.101985

Correction in:: J Biol Chem. 2023 Jan; 299(1): 102807.

PMCID:: PMC9136129

Abstract Article PDF–3.1M

Select item 79853238.

Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis

Zihao Li, Mian Wang, Hua Zhong, Xin Huang, Xinyin Wu, Xian Zhang, Jing Wang, Jing Deng, Mengshi Chen, Lizhang Chen, Hongzhuan Tan

Sci Rep. 2021; 11: 6544. Published online 2021 Mar 22. doi: 10.1038/s41598-021-86129-x

PMCID:: PMC7985323

Abstract Article PDF–948K

Select item 79797059.

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu

NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3

PMCID:: PMC7979705

Abstract Article PDF–6.8M

Select item 775805010.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 752133511.

Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus

Wang‐Dong Xu, Xiao‐Yan Liu, Lin‐Chong Su, An‐Fang Huang

J Cell Mol Med. 2020 Sep; 24(18): 10432–10443. Published online 2020 Jul 17. doi: 10.1111/jcmm.15656

PMCID:: PMC7521335

Abstract Article PDF–560K

Select item 740515912.

MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti‐MASP2 antibody narsoplimab

S. Elhadad, J. Chapin, D. Copertino, K. Van Besien, J. Ahamed, J. Laurence

Clin Exp Immunol. 2021 Jan; 203(1): 96–104. Published online 2020 Aug 5. doi: 10.1111/cei.13497

PMCID:: PMC7405159

Abstract Article PDF–326K

Select item 722397213.

Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway

M. Isabel García-Laorden, Elisa Hernández-Brito, Carmen Muñoz-Almagro, Svetlana Pavlovic-Nesic, Iñigo Rúa-Figueroa, M. Luisa Briones, Olga Rajas, Luis Borderías, Antoni Payeras, Leonardo Lorente, Jordi Freixinet, Jose Ferreres, Ignacio Obando, Nereida González-Quevedo, Felipe Rodríguez de Castro, Jordi Solé-Violán, Carlos Rodríguez-Gallego

J Clin Immunol. 2020; 40(1): 203–210. Published online 2019 Dec 11. doi: 10.1007/s10875-019-00714-4

PMCID:: PMC7223972

Abstract Article PDF–409K

Select item 711536914.

MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection

Siumara Tulio, Fabio R. Faucz, Renata I. Werneck, Márcia Olandoski, Rodrigo B. Alexandre, Angélica B.W. Boldt, Maria Lucia Pedroso, Iara J. de Messias-Reason

Hum Immunol. 2011 Oct; 72(10): 912–915. Published online 2011 Jul 31. doi: 10.1016/j.humimm.2011.06.016

PMCID:: PMC7115369

Abstract Article PDF–249K

Select item 711267415.

MBL-associated serine proteases (MASPs) and infectious diseases

Marcia H. Beltrame, Angelica B.W. Boldt, Sandra J. Catarino, Hellen C. Mendes, Stefanie E. Boschmann, Isabela Goeldner, Iara Messias-Reason

Mol Immunol. 2015 Sep; 67(1): 85–100. Published online 2015 Apr 8. doi: 10.1016/j.molimm.2015.03.245

PMCID:: PMC7112674

Abstract Article PDF–1.1M

Select item 709987716.

MAp19, the alternative splice product of the MASP2 gene

Søren E. Degn, Steffen Thiel, Ole Nielsen, Annette G. Hansen, Rudi Steffensen, Jens C. Jensenius

J Immunol Methods. 2011 Oct 28; 373(1): 89–101. Published online 2011 Aug 17. doi: 10.1016/j.jim.2011.08.006

PMCID:: PMC7099877

Abstract Article PDF–1.2M

Select item 694438917.

Herpes simplex encephalitis in adult patients with MASP-2 deficiency

Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard, Florence Fellmann, Carlo Rivolta, Guy Boivin, Pierre-Yves Bochud

PLoS Pathog. 2019 Dec; 15(12): e1008168. Published online 2019 Dec 23. doi: 10.1371/journal.ppat.1008168