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Select item 108477481.

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism

Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi

Blood Adv. 2024 Feb 13; 8(3): 785–796. Published online 2024 Jan 3. doi: 10.1182/bloodadvances.2023010080

PMCID:: PMC10847748

Abstract Article PDF–2.5M

Select item 103160632.

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron

Saki Ichikawa, Hope A. Flaxman, Wenqing Xu, Nandini Vallavoju, Hannah C. Lloyd, Binyou Wang, Dacheng Shen, Matthew R. Pratt, Christina M. Woo

Nature. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Nature. 2022 Oct; 610(7933): 775–782. Published online 2022 Oct 19. doi: 10.1038/s41586-022-05333-5

PMCID:: PMC10316063

Abstract Article PDF–5.2M

Select item 101415813.

Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ

Phillip Zhu, Stanislau Stanisheuski, Rachel Franklin, Amber Vogel, Cat Hoang Vesely, Patrick Reardon, Nikolai N. Sluchanko, Joseph S. Beckman, P. Andrew Karplus, Ryan A. Mehl, Richard B. Cooley

ACS Cent Sci. 2023 Apr 26; 9(4): 816–835. Published online 2023 Apr 10. doi: 10.1021/acscentsci.3c00191

PMCID:: PMC10141581

Abstract Article PDF–9.1M

Select item 97725584.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 97145265.

Molecular glue CELMoD compounds are regulators of cereblon conformation

Edmond R. Watson, Scott Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres H. de la Peña, Jinyi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander

Science. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Science. 2022 Nov 4; 378(6619): 549–553. Published online 2022 Nov 3. doi: 10.1126/science.add7574

PMCID:: PMC9714526

Abstract Article PDF–1.3M

Select item 95136766.

CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells

Mi‐Jeong Kim, Ji Su Lee, Ji Young Kim, Bongkum Choi, Juhee Son, Yoon Min, Soo‐Kyung Jeong, Duk‐Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki‐Young Lee

Clin Transl Med. 2022 Sep; 12(9): e1050. Published online 2022 Sep 27. doi: 10.1002/ctm2.1050

PMCID:: PMC9513676

Article PDF–3.6M

Select item 93525467.

The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon

Chen Shen, Anmada Nayak, Leif R. Neitzel, Fan Yang, Bin Li, Charles H. Williams, Charles C. Hong, Yashi Ahmed, Ethan Lee, David J. Robbins

J Biol Chem. 2022 Aug; 298(8): 102227. Published online 2022 Jul 1. doi: 10.1016/j.jbc.2022.102227

PMCID:: PMC9352546

Abstract Article PDF–1.6M

Select item 93205528.

E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism

Jun Shao, Qian Feng, Weifan Jiang, Yuting Yang, Zhiqiang Liu, Liang Li, Wenlong Yang, Yufeng Zou

Aging (Albany NY) 2022 Jul 15; 14(13): 5493–5510. Published online 2022 Jul 8. doi: 10.18632/aging.204163

PMCID:: PMC9320552

Abstract Article PDF–1.8M

Select item 92911489.

Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation

Cinzia Fionda, Helena Stabile, Rosa Molfetta, Andrea Kosta, Giovanna Peruzzi, Silvia Ruggeri, Alessandra Zingoni, Cristina Capuano, Alessandra Soriani, Rossella Paolini, Angela Gismondi, Marco Cippitelli, Angela Santoni

Eur J Immunol. 2021 Nov; 51(11): 2607–2617. Published online 2021 Sep 18. doi: 10.1002/eji.202149269

PMCID:: PMC9291148

Abstract Article PDF–1.6M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 889702211.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 881951912.

Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

Shaunna L. Beedie, Phoebe A. Huang, Emily M. Harris, Jonathan D. Strope, Christopher Mahony, Cindy H. Chau, Neil Vargesson, William D. Figg

FASEB J. Author manuscript; available in PMC 2022 Feb 7.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 11395–11404. Published online 2020 Jul 17. doi: 10.1096/fj.201903060RR

PMCID:: PMC8819519

Abstract Article PDF–1.1M

Select item 874863013.

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

Satoshi Yamanaka, Yuto Horiuchi, Saya Matsuoka, Kohki Kido, Kohei Nishino, Mayaka Maeno, Norio Shibata, Hidetaka Kosako, Tatsuya Sawasaki

Nat Commun. 2022; 13: 183. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27818-z

PMCID:: PMC8748630

Abstract Article PDF–2.8M

Select item 858633614.

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito

Commun Biol. 2021; 4: 1277. Published online 2021 Nov 11. doi: 10.1038/s42003-021-02801-y

PMCID:: PMC8586336

Abstract Article PDF–2.1M

Select item 856941115.

Cereblon enhancer methylation and IMiD resistance in multiple myeloma

Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Cornelia Vogt, Rafael Alonso Fernández, Max Bittrich, Yanira Ruiz-Heredia, Matteo Da Viá, Josip Zovko, Andoni Garitano-Trojaola, Niccolò Bolli, Anna Ruckdeschel, Thorsten Stühmer, Manik Chatterjee, Miriam Kull, Jan Krönke, Xabier Agirre, Jose I. Martin-Subero, Peter Raab, Hermann Einsele, Leo Rasche, Joaquin Martinez-Lopez, Thomas Haaf, K. Martin Kortüm

Blood. 2021 Nov 4; 138(18): 1721–1726. doi: 10.1182/blood.2020010452

PMCID:: PMC8569411

Abstract Article

Select item 847864016.

Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs

J. R. Jones, A. Barber, Y-V Le Bihan, N. Weinhold, C. Ashby, B. A. Walker, C. P. Wardell, H. Wang, M. F. Kaiser, G. H. Jackson, F. E. Davies, R. Chopra, G. J. Morgan, C. Pawlyn

Leukemia. 2021; 35(10): 3017–3020. Published online 2021 Aug 9. doi: 10.1038/s41375-021-01373-4

PMCID:: PMC8478640

Article PDF–961K

Select item 842136617.

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins

Nat Commun. 2021; 12: 5263. Published online 2021 Sep 6. doi: 10.1038/s41467-021-25634-z

PMCID:: PMC8421366

Abstract Article PDF–3.4M

Select item 822811418.

Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4^CRBN Protein Degradation Axis

Seung-Joo Yang, Seungje Jeon, Jeong Won Baek, Kwang Min Lee, Chul-Seung Park

Pharmaceuticals (Basel) 2021 Jun; 14(6): 512. Published online 2021 May 26. doi: 10.3390/ph14060512

PMCID:: PMC8228114

Abstract Article PDF–1.4M

Select item 821153819.

Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1

Uroos Akber, Heeji Jo, Seungje Jeon, Seung-Joo Yang, Sunhwa Bong, Sungsu Lim, Yun Kyung Kim, Zee-Yong Park, Chul-Seung Park

J Neurosci. 2021 Jun 16; 41(24): 5138–5156. doi: 10.1523/JNEUROSCI.2494-20.2021

PMCID:: PMC8211538

Abstract Article PDF–6.9M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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