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Select item 101415081.

Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b

Lindsey A. Lee, Samantha K. Barrick, Ada E. Buvoli, Jonathan Walklate, W. Tom Stump, Michael Geeves, Michael J. Greenberg, Leslie A. Leinwand

J Biol Chem. 2023 May; 299(5): 104631. Published online 2023 Mar 22. doi: 10.1016/j.jbc.2023.104631

PMCID:: PMC10141508

Abstract Article PDF–1.7M

Select item 98002082.

Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles

Lindsey A. Lee, Samantha K. Barrick, Artur Meller, Jonathan Walklate, Jeffrey M. Lotthammer, Jian Wei Tay, W. Tom Stump, Gregory Bowman, Michael A. Geeves, Michael J. Greenberg, Leslie A. Leinwand

J Biol Chem. 2023 Jan; 299(1): 102657. Published online 2022 Nov 9. doi: 10.1016/j.jbc.2022.102657

PMCID:: PMC9800208

Abstract Article PDF–4.5M

Select item 83641813.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81418955.

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart

Lindsey J. Broadwell, Michael J. Smallegan, Kevin M. Rigby, Jose S. Navarro-Arriola, Rusty L. Montgomery, John L. Rinn, Leslie A. Leinwand

J Biol Chem. 2021 Jan-Jun; 296: 100694. Published online 2021 Apr 22. doi: 10.1016/j.jbc.2021.100694

PMCID:: PMC8141895

Abstract Article PDF–2.5M

Select item 80177206.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 75423567.

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

Jaya Bhushan, Joshua B. Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J. Lenschow, Herbert W. Virgin, L. David Sibley

mBio. 2020 Sep-Oct; 11(5): e00852-20. Published online 2020 Oct 6. doi: 10.1128/mBio.00852-20

PMCID:: PMC7542356

Abstract Article PDF–2.4M

Select item 75267228.

Phosphorylated tau interactome in the human Alzheimer’s disease brain

Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewski

Brain. 2020 Sep; 143(9): 2803–2817. Published online 2020 Aug 19. doi: 10.1093/brain/awaa223

PMCID:: PMC7526722

Abstract Article PDF–1.1M

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 679649210.

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

Shouhua Wang, Yongjie Zhang, Qiang Cai, Mingzhe Ma, Long Yang Jin, Mingzhe Weng, Di Zhou, Zhaohui Tang, Jian Dong Wang, Zhiwei Quan

Mol Cancer. 2019; 18: 145. Published online 2019 Oct 17. doi: 10.1186/s12943-019-1078-z

PMCID:: PMC6796492

Abstract Article PDF–4.1M

Select item 616668211.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 511781613.

Myosin-7b promotes distal tip localization of the intermicrovillar adhesion complex

Meredith L. Weck, Scott W. Crawley, Colin R. Stone, Matthew J. Tyska

Curr Biol. Author manuscript; available in PMC 2017 Oct 24.

Published in final edited form as: Curr Biol. 2016 Oct 24; 26(20): 2717–2728. Published online 2016 Sep 22. doi: 10.1016/j.cub.2016.08.014

PMCID:: PMC5117816

Abstract Article PDF–3.2M

Select item 503652714.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

Select item 482661415.

?F508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis

Sandra Pankow, Casimir Bamberger, Diego Calzolari, Salvador Martínez-Bartolomé, Mathieu Lavallée-Adam, William E. Balch, John R. Yates, III

Nature. Author manuscript; available in PMC 2016 May 30.

Published in final edited form as: Nature. 2015 Dec 24; 528(7583): 510–516. Published online 2015 Nov 30. doi: 10.1038/nature15729

PMCID:: PMC4826614

Abstract Article PDF–5.7M

Select item 438092816.

Phospho-tyrosine dependent protein–protein interaction network

Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968

PMCID:: PMC4380928

Abstract Article PDF–1.9M

Select item 370730517.

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells

J-Y Chuang, S-A Wang, W-B Yang, H-C Yang, C-Y Hung, T-P Su, W-C Chang, J-J Hung

Oncogene. Author manuscript; available in PMC 2013 Jul 10.

Published in final edited form as: Oncogene. 2012 Nov 22; 31(47): 4946–4959. Published online 2012 Jan 23. doi: 10.1038/onc.2011.649

PMCID:: PMC3707305

Abstract Article PDF–6.7M

Select item 369585118.

Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy

Teresa Esposito, Simone Sampaolo, Giuseppe Limongelli, Antonio Varone, Daniela Formicola, Daria Diodato, Olimpia Farina, Filomena Napolitano, Giuseppe Pacileo, Fernando Gianfrancesco, Giuseppe Di Iorio

Orphanet J Rare Dis. 2013; 8: 91. Published online 2013 Jun 21. doi: 10.1186/1750-1172-8-91

PMCID:: PMC3695851

Abstract Article PDF–3.8M

Select item 339727319.

Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease

Weihong Tang, Christine Schwienbacher, Lorna M. Lopez, Yoav Ben-Shlomo, Tiphaine Oudot-Mellakh, Andrew D. Johnson, Nilesh J. Samani, Saonli Basu, Martin Gögele, Gail Davies, Gordon D.O. Lowe, David-Alexandre Tregouet, Adrian Tan, James S. Pankow, Albert Tenesa, Daniel Levy, Claudia B. Volpato, Ann Rumley, Alan J. Gow, Cosetta Minelli, John W.G. Yarnell, David J. Porteous, John M. Starr, John Gallacher, Eric Boerwinkle, Peter M. Visscher, Peter P. Pramstaller, Mary Cushman, Valur Emilsson, Andrew S. Plump, Nena Matijevic, Pierre-Emmanuel Morange, Ian J. Deary, Andrew A. Hicks, Aaron R. Folsom

Am J Hum Genet. 2012 Jul 13; 91(1): 152–162. doi: 10.1016/j.ajhg.2012.05.009

PMCID:: PMC3397273

Abstract Article PDF–367K

Select item 324725820.

A Genome-Wide Association Study of the Protein C Anticoagulant Pathway

Georgios Athanasiadis, Alfonso Buil, Juan Carlos Souto, Montserrat Borrell, Sonia López, Angel Martinez-Perez, Mark Lathrop, Jordi Fontcuberta, Laura Almasy, José Manuel Soria

PLoS One. 2011; 6(12): e29168. Published online 2011 Dec 28. doi: 10.1371/journal.pone.0029168

PMCID:: PMC3247258

Abstract Article PDF–295K

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