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Select item 111011731.

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

Gang Liu, Yunxuan Hou, Xin Jin, Yixue Zhang, Chaoyue Sun, Chengquan Huang, Yujie Ren, Jianmin Gao, Xiuli Wang, Xiumei Jiang

eLife. 2024; 13: RP95815. Published online 2024 May 17. doi: 10.7554/eLife.95815

PMCID:: PMC11101173

Abstract Article PDF–12M

Select item 110760432.

Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

Benjamin R Duewell, Naomi E Wilson, Gabriela M Bailey, Sarah E Peabody, Scott D Hansen

eLife. 2024; 12: RP88991. Published online 2024 May 7. doi: 10.7554/eLife.88991

PMCID:: PMC11076043

Abstract Article PDF–3.0M

Select item 110732893.

SUMOylation modulates the stability and function of PI3K-p110β

Ahmed El Motiam, Carlos F. de la Cruz-Herrera, Santiago Vidal, Rocío Seoane, Maite Baz-Martínez, Yanis H. Bouzaher, Emilio Lecona, Mariano Esteban, Manuel S. Rodríguez, Anxo Vidal, Manuel Collado, Carmen Rivas

Cell Mol Life Sci. 2021 Apr; 78(8): 4053–4065. Published online 2021 Apr 8. doi: 10.1007/s00018-021-03826-6

PMCID:: PMC11073289

Abstract Article PDF–2.7M

Select item 104852844.

AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20)

Koung Jin Suh, Min-Hee Ryu, Dae Young Zang, Woo Kyun Bae, Hye Seung Lee, Hyeon Jeong Oh, Minsu Kang, Ji-Won Kim, Bum Jun Kim, Peter G S Mortimer, Hee Jung Kim, Keun-Wook Lee

Oncologist. 2023 Sep; 28(9): e823–e834. Published online 2023 Apr 10. doi: 10.1093/oncolo/oyad059

Correction in:: Oncologist. 2024 Apr; 29(4): e579.

PMCID:: PMC10485284

Abstract Article PDF–2.6M

Select item 95616455.

PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression

Sudhanshu Yadav, Antonio Garrido, M. Carmen Hernández, Juan C. Oliveros, Vicente Pérez-García, Mario F. Fraga, Ana C. Carrera

Stem Cell Reports. 2022 Oct 11; 17(10): 2239–2255. Published online 2022 Sep 29. doi: 10.1016/j.stemcr.2022.09.003

PMCID:: PMC9561645

Abstract Article PDF–5.6M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91714117.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90271229.

CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells

Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang

Mol Cancer. 2022; 21: 103. Published online 2022 Apr 22. doi: 10.1186/s12943-022-01524-w

PMCID:: PMC9027122

Abstract Article PDF–12M

Select item 888591110.

PIP₃ abundance overcomes PI3K signaling selectivity in invadopodia

Charles T. Jakubik, Claire C. Weckerly, Gerald R.V. Hammond, Anne R. Bresnick, Jonathan M. Backer

FEBS Lett. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: FEBS Lett. 2022 Feb; 596(4): 417–426. Published online 2022 Jan 12. doi: 10.1002/1873-3468.14273

PMCID:: PMC8885911

Abstract Article PDF–1.1M

Select item 861639011.

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL

Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado, Ana C. Carrera

Cells. 2021 Nov; 10(11): 2803. Published online 2021 Oct 20. doi: 10.3390/cells10112803

PMCID:: PMC8616390

Abstract Article PDF–4.6M

Select item 846392512.

PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer

Jianhua Qu, Biao Zheng, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Xianbin Zhang, Rui Liang, Zhong Liu, Kengo Shirahane, Kazuhiro Mizumoto, Peng Gong, Masafumi Nakamura

J Adv Res. 2021 Nov; 33: 127–140. Published online 2021 Feb 17. doi: 10.1016/j.jare.2021.02.002

PMCID:: PMC8463925

Abstract Article PDF–7.6M

Select item 836418113.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813382915.

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Nisha Raj, Zachary T. McEachin, William Harousseau, Ying Zhou, Feiran Zhang, Megan E. Merritt-Garza, J. Matthew Taliaferro, Magdalena Kalinowska, Samuele G. Marro, Chadwick M. Hales, Elizabeth Berry-Kravis, Marisol W. Wolf-Ochoa, Veronica Martinez-Cerdeño, Marius Wernig, Lu Chen, Eric Klann, Stephen T. Warren, Peng Jin, Zhexing Wen, Gary J. Bassell

Cell Rep. Author manuscript; available in PMC 2021 May 19.

Published in final edited form as: Cell Rep. 2021 Apr 13; 35(2): 108991. doi: 10.1016/j.celrep.2021.108991

PMCID:: PMC8133829

Abstract Article PDF–1.8M

Select item 761053516.

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

Bikash Adhikari, Jelena Bozilovic, Mathias Diebold, Jessica Denise Schwarz, Julia Hofstetter, Martin Schröder, Marek Wanior, Ashwin Narain, Markus Vogt, Nevenka Dudvarski Stankovic, Apoorva Baluapuri, Lars Schönemann, Lorenz Eing, Pranjali Bhandare, Bernhard Kuster, Andreas Schlosser, Stephanie Heinzlmeir, Christoph Sotriffer, Stefan Knapp, Elmar Wolf

Nat Chem Biol. Author manuscript; available in PMC 2021 Apr 6.

Published in final edited form as: Nat Chem Biol. 2020 Nov 1; 16(11): 1179–1188. Published online 2020 Sep 28. doi: 10.1038/s41589-020-00652-y

PMCID:: PMC7610535

Abstract Article PDF–5.1M

Select item 756688117.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 742732718.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 730521619.

YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC

Yanwei Cui, Fengzhou Li, Qiang Xie, Shilei Zhao, Tao Guo, Ping Guo, Sheng Hu, Jiaojiao Hao, Chunfang Tian, Wendan Yu, Zhuoshi Li, Lei Fang, Lei Zhao, Manyu Chen, Taihua Wu, Chundong Gu

Cell Death Dis. 2020 Jun; 11(6): 476. Published online 2020 Jun 19. doi: 10.1038/s41419-020-2555-4

PMCID:: PMC7305216

Abstract Article PDF–2.8M

Select item 712771820.

Infection of Human Immunodeficiency Virus and Intracellular Viral Tat Protein Exert a Pro-survival Effect in a Human Microglial Cell Line

Pauline Chugh, Shongshan Fan, Vicente Planelles, Sanjay B. Maggirwar, Stephen Dewhurst, Baek Kim

J Mol Biol. 2007 Feb 9; 366(1): 67–81. Published online 2006 Nov 10. doi: 10.1016/j.jmb.2006.11.011

PMCID:: PMC7127718

Abstract Article PDF–1.1M

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PMC Links for GEO Profiles (Select 78312206) (136)
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BX100788 Soares_testis_NHT Homo sapiens cDNA clone IMAGp998C243521; IMAGE:139425...
BX100788 Soares_testis_NHT Homo sapiens cDNA clone IMAGp998C243521; IMAGE:1394255 5', mRNA sequence
gi|27844627|gnl|dbEST|16750495|emb| 788.1|

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