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Select item 112224261.

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Jennifer M. Hayashi, Irene P. Chen, Mir M. Khalid, Nathan L. Meyers, Taha Y. Taha, Kristoffer E. Leon, Rahul K. Suryawanshi, Maria McCavitt-Malvido, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen P. Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott

Sci Rep. 2024; 14: 15351. Published online 2024 Jul 4. doi: 10.1038/s41598-024-66003-2

PMCID:: PMC11222426

Abstract Article PDF–4.0M

Select item 111598882.

Potential biomarkers involving IKK/RelA signal in early stage non‐small cell lung cancer

Xianqing Jin, Ziming Wang, Lin Qiu, Dianliang Zhang, Zhenhua Guo, Zongwei Gao, Chun Deng, Fuling Wang, Shan Wang, Chunbao Guo

Cancer Sci. 2008 Mar; 99(3): 582–589. Published online 2008 Jan 21. doi: 10.1111/j.1349-7006.2007.00713.x

PMCID:: PMC11159888

Abstract Article PDF–254K

Select item 111154963.

Annexin A4 interacts with the NF-κB p50 subunit and modulates NF-κB transcriptional activity in a Ca²⁺-dependent manner

Young-Joo Jeon, Do-Hyung Kim, Hyeyun Jung, Sang J. Chung, Seung-Wook Chi, Sayeon Cho, Sang Chul Lee, Byoung Chul Park, Sung Goo Park, Kwang-Hee Bae

Cell Mol Life Sci. 2010 Jul; 67(13): 2271–2281. Published online 2010 Mar 18. doi: 10.1007/s00018-010-0331-9

PMCID:: PMC11115496

Abstract Article PDF–659K

Select item 108501344.

ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling

Ying He, Qian Shi, Yuhang Ling, Huihui Guo, Yi Fei, Ruoyu Wu, Chengwu Tang, Xilin Zhang, Linhua Yao

Cell Death Differ. 2024 Feb; 31(2): 203–216. Published online 2024 Jan 16. doi: 10.1038/s41418-024-01256-y

PMCID:: PMC10850134

Abstract Article PDF–6.4M

Select item 105687855.

Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation

Yuanbang Lin, Mingwei Sheng, Hua Qin, Peng Zhang, Chunli Wang, Wei Fu, Xiangjun Meng, Duowei Wang, Yachao Hou

Cell Commun Signal. 2023; 21: 282. Published online 2023 Oct 12. doi: 10.1186/s12964-023-01287-x

PMCID:: PMC10568785

Abstract Article PDF–12M

Select item 104067146.

TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination

Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong

Cell Biol Toxicol. 2023; 39(3): 607–620. Published online 2022 Oct 14. doi: 10.1007/s10565-022-09768-4

PMCID:: PMC10406714

Abstract Article PDF–6.6M

Select item 103141227.

Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas

Markus Bredel, Lluís Espinosa, Hyunsoo Kim, Denise M. Scholtens, Joseph P. McElroy, Rajani Rajbhandari, Wei Meng, Thomas M. Kollmeyer, Tathiane M. Malta, Michael A. Quezada, Griffith R. Harsh, Teresa Lobo-Jarne, Laura Solé, Aran Merati, Surya Nagaraja, Sindhu Nair, Jaclyn J. White, Nanda K. Thudi, Jessica L. Fleming, Amy Webb, Atsushi Natsume, Seishi Ogawa, Ruthild G. Weber, Joan Bertran, S. Jaharul Haque, Bettina Hentschel, C. Ryan Miller, Frank B. Furnari, Timothy A. Chan, Anca-Ligia Grosu, Michael Weller, Jill S. Barnholtz-Sloan, Michelle Monje, Houtan Noushmehr, Robert B. Jenkins, C. Leland Rogers, David R. MacDonald, Stephanie L. Pugh, Arnab Chakravarti

Cell Rep Med. 2023 Jun 20; 4(6): 101082. Published online 2023 Jun 20. doi: 10.1016/j.xcrm.2023.101082

PMCID:: PMC10314122

Abstract Article PDF–6.5M

Select item 101543018.

Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC)

Ethan L. Morgan, Tiffany Toni, Ramya Viswanathan, Yvette Robbins, Xinping Yang, Hui Cheng, Sreenivasulu Gunti, Angel Huynh, Anastasia L. Sowers, James B. Mitchell, Clint T. Allen, Zhong Chen, Carter Van Waes

Cell Death Differ. 2023 May; 30(5): 1382–1396. Published online 2023 Apr 13. doi: 10.1038/s41418-023-01144-x

PMCID:: PMC10154301

Abstract Article PDF–7.0M

Select item 100398609.

IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

Yanquan Li, Youwei Hu, Zhengquan Wang, Tingting Lu, Yiting Yang, Hua Diao, Xiaoguo Zheng, Chong Xie, Ping Zhang, Xuelian Zhang, Yuchuan Zhou

Commun Biol. 2023; 6: 323. Published online 2023 Mar 25. doi: 10.1038/s42003-023-04693-6

PMCID:: PMC10039860

Abstract Article PDF–3.4M

Select item 990801110.

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

Christopher Nardone, Brad A. Palanski, Daniel C. Scott, Richard T. Timms, Karl W. Barber, Xin Gu, Aoyue Mao, Yumei Leng, Emma V. Watson, Brenda A. Schulman, Philip A. Cole, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2023 Feb 14.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 57–73.e9. doi: 10.1016/j.molcel.2022.12.013

PMCID:: PMC9908011

Abstract Article PDF–2.9M

Select item 968395911.

Identification of Key Genes and miRNAs Affecting Osteosarcoma Based on Bioinformatics

Le Li, Xin Zhou, Wencan Zhang, Ran Zhao

Dis Markers. 2022; 2022: 1015593. Published online 2022 Nov 16. doi: 10.1155/2022/1015593

PMCID:: PMC9683959

Abstract Article PDF–2.1M

Select item 960206712.

A Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia

Chai Teng Chear, Bader Abdul Kader El Farran, Marina Sham, Kavetha Ramalingam, Lokman Mohd Noh, Intan Hakimah Ismail, Mei Yee Chiow, Mohd Farid Baharin, Adiratna Mat Ripen, Saharuddin Bin Mohamad

Genes (Basel) 2022 Oct; 13(10): 1900. Published online 2022 Oct 19. doi: 10.3390/genes13101900

PMCID:: PMC9602067

Abstract Article PDF–2.0M

Select item 944303513.

TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination

Hangqi Shen, Qiaoyun Gong, Jingting Zhang, Haiyan Wang, Qinghua Qiu, Jingfa Zhang, Dawei Luo

Eye Vis (Lond) 2022; 9: 35. Published online 2022 Sep 5. doi: 10.1186/s40662-022-00305-2

PMCID:: PMC9443035

Abstract Article PDF–3.5M

Select item 943393814.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 934596115.

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Fubing Li, Huichun Liang, Hua You, Ji Xiao, Houjun Xia, Xi Chen, Maobo Huang, Zhuo Cheng, Chuanyu Yang, Wenjing Liu, Hailin Zhang, Li Zeng, Yingying Wu, Fei Ge, Zhen Li, Wenhui Zhou, Yi Wen, Zhongmei Zhou, Rong Liu, Dewei Jiang, Ni Xie, Bin Liang, Zhenzhen Liu, Yanjie Kong, Ceshi Chen

Signal Transduct Target Ther. 2022; 7: 264. Published online 2022 Aug 3. doi: 10.1038/s41392-022-01057-0

PMCID:: PMC9345961

Abstract Article PDF–6.4M

Select item 927928516.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 921264917.

Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients

Daniel G. Camblor, Daniel Miranda, Guillermo M. Albaiceta, Laura Amado-Rodríguez, Elías Cuesta-Llavona, Daniel Vázquez-Coto, Julia Gómez de Oña, Claudia García-Lago, Juan Gómez, Eliecer Coto

Hum Immunol. 2022 August-September; 83(8): 613–617. Published online 2022 Jun 21. doi: 10.1016/j.humimm.2022.06.002

PMCID:: PMC9212649

Abstract Article PDF–540K

Select item 911973618.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 884266619.

ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability

Pin Wan, Ge Yang, Simeng Zhang, Yaru Zhang, Yaling Jia, Xu Che, Zhen Luo, Pan Pan, Geng Li, Xulin Chen, Qiwei Zhang, Wen Zhang, Qiuping Tan, Yongkui Li, Jianguo Wu

Front Cell Infect Microbiol. 2022; 12: 759077. Published online 2022 Jan 31. doi: 10.3389/fcimb.2022.759077

PMCID:: PMC8842666

Abstract Article PDF–8.5M

Select item 882889520.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

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