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Select item 102926341.

FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial-Mesenchymal Transition

Bo Dong, Laura Simonson, Samantha Vold, Ethan Oldham, Lillian Barten, Nihal Ahmad, Hao Chang

J Invest Dermatol. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: J Invest Dermatol. 2023 Apr; 143(4): 621–629.e6. Published online 2022 Nov 9. doi: 10.1016/j.jid.2022.09.658

PMCID:: PMC10292634

Abstract Article PDF–2.2M

Select item 92316232.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 84517584.

FZD6 triggers Wnt–signalling driven by WNT10B^IVS1 expression and highlights new targets in T‐cell acute lymphoblastic leukemia

Adriana Cassaro, Giovanni Grillo, Marco Notaro, Jessica Gliozzo, Ilaria Esposito, Gianluigi Reda, Alessandra Trojani, Giorgio Valentini, Barbara Di Camillo, Roberto Cairoli, Alessandro Beghini

Hematol Oncol. 2021 Aug; 39(3): 364–379. Published online 2021 Feb 16. doi: 10.1002/hon.2840

PMCID:: PMC8451758

Abstract Article PDF–1.7M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79797056.

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu

NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3

PMCID:: PMC7979705

Abstract Article PDF–6.8M

Select item 76641207.

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane

Molly M. Hannigan, Alyson M. Hoffman, J. Will Thompson, Tianli Zheng, Christopher V. Nicchitta

Mol Cell Proteomics. 2020 Nov; 19(11): 1826–1849. Published online 2020 Aug 10. doi: 10.1074/mcp.RA120.002228

PMCID:: PMC7664120

Abstract Article PDF–4.8M

Select item 74870408.

Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects

Tian Tian, Yunping Lei, Yongyan Chen, Menuka Karki, Lei Jin, Richard H. Finnell, Linlin Wang, Aiguo Ren

Hum Genet. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Hum Genet. 2020 Oct; 139(10): 1299–1314. Published online 2020 Apr 30. doi: 10.1007/s00439-020-02172-0

PMCID:: PMC7487040

Abstract Article PDF–1.5M

Select item 72067939.

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Jin Huk Choi, Xue Zhong, William McAlpine, Tzu-Chieh Liao, Duanwu Zhang, Beibei Fang, Jamie Russell, Sara Ludwig, Evan Nair-Gill, Zhao Zhang, Kuan-wen Wang, Takuma Misawa, Xiaoming Zhan, Mihwa Choi, Tao Wang, Xiaohong Li, Miao Tang, Qihua Sun, Liyang Yu, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler

Science. Author manuscript; available in PMC 2020 May 8.

Published in final edited form as: Science. 2019 May 10; 364(6440): eaau0812. doi: 10.1126/science.aau0812

PMCID:: PMC7206793

Abstract Article PDF–2.2M

Select item 639924010.

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

Chunjie Xu, Guangang Tian, Chunhui Jiang, Hanbing Xue, Manzila Kuerbanjiang, Longci Sun, Lei Gu, Hong Zhou, Ye Liu, Zhigang Zhang, Qing Xu

Cell Death Dis. 2019 Mar; 10(3): 217. Published online 2019 Mar 4. doi: 10.1038/s41419-019-1467-7

PMCID:: PMC6399240

Abstract Article PDF–4.7M

Select item 638658811.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 633261612.

A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia

Ceren Saygı, Yasemin Alanay, Uğur Sezerman, Aslı Yenenler, Nesrin Özören

BMC Med Genet. 2019; 20: 15. Published online 2019 Jan 14. doi: 10.1186/s12881-019-0746-6

PMCID:: PMC6332616

Abstract Article PDF–1.9M

Select item 629014513.

Dishevelled enables casein kinase 1–mediated phosphorylation of Frizzled 6 required for cell membrane localization

Katerina Strakova, Maria Kowalski-Jahn, Tomas Gybel, Jana Valnohova, Vishnu M. Dhople, Jakub Harnos, Ondrej Bernatik, Ranjani Sri Ganji, Zbynek Zdrahal, Jan Mulder, Cecilia Lindskog, Vitezslav Bryja, Gunnar Schulte

J Biol Chem. 2018 Nov 30; 293(48): 18477–18493. Published online 2018 Oct 11. doi: 10.1074/jbc.RA118.004656

PMCID:: PMC6290145

Abstract Article PDF–5.3M

Select item 624085414.

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment

Jana Valnohova, Maria Kowalski-Jahn, Roger K. Sunahara, Gunnar Schulte

J Biol Chem. 2018 Nov 16; 293(46): 17875–17887. Published online 2018 Sep 19. doi: 10.1074/jbc.RA118.004763

PMCID:: PMC6240854

Abstract Article PDF–3.1M

Select item 599212715.

LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation

Zhenzhen Chen, Yanfeng Gao, Lintong Yao, Yating Liu, Lan Huang, Zhongyi Yan, Wenshan Zhao, Pingping Zhu, Haibo Weng

Oncogene. 2018; 37(23): 3098–3112. Published online 2018 Mar 14. doi: 10.1038/s41388-018-0203-6

Correction in:: Oncogene. 2022; 41(34): 4115–4118.

PMCID:: PMC5992127

Abstract Article PDF–8.2M

Select item 598674116.

Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics

Kun Han, Tingyuan Lang, Zhiqi Zhang, Yi Zhang, Yongning Sun, Zan Shen, Roger W. Beuerman, Lei Zhou, Daliu Min

Sci Rep. 2018; 8: 8537. Published online 2018 Jun 4. doi: 10.1038/s41598-018-26761-2

PMCID:: PMC5986741

Abstract Article PDF–5.3M

Select item 554874517.

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Julian Petersen, Shane C. Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson, Gunnar Schulte

Nat Commun. 2017; 8: 226. Published online 2017 Aug 9. doi: 10.1038/s41467-017-00253-9

PMCID:: PMC5548745

Abstract Article PDF–2.6M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 524860119.

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer

Gabriele Corda, Gianluca Sala, Rossano Lattanzio, Manuela Iezzi, Michele Sallese, Giorgia Fragassi, Alessia Lamolinara, Hasan Mirza, Daniela Barcaroli, Sibylle Ermler, Elisabete Silva, Hemad Yasaei, Robert F Newbold, Paola Vagnarelli, Marcella Mottolese, Pier Giorgio Natali, Letizia Perracchio, Jelmar Quist, Anita Grigoriadis, Pierfrancesco Marra, Andrew N Tutt, Mauro Piantelli, Stefano Iacobelli, Vincenzo De Laurenzi, Arturo Sala

J Pathol. 2017 Feb; 241(3): 350–361. Published online 2016 Dec 29. doi: 10.1002/path.4841

PMCID:: PMC5248601

Abstract Article PDF–2.0M

Select item 513209020.

Isolated recessive nail dysplasia caused by FZD6 mutations: report of three families and review of the literature

C. Kasparis, D. Reid, N. J. Wilson, V. Okur, C. Cole, C. D. Hansen, K. Bosse, R. C. Betz, M. Khan, F. J. D. Smith

Clin Exp Dermatol. 2016 Dec; 41(8): 884–889. Published online 2016 Oct 27. doi: 10.1111/ced.12934

PMCID:: PMC5132090

Abstract Article PDF–574K

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