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Select item 112342211.

Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity

Luning Mao, Lan Wang, Yingying Lyu, Qiyuan Zhuang, Zhujun Li, Jialong Zhang, Zhiyan Gu, Shaohua Lu, Xin Wang, Yun Guan, Ji Xiong, Yin Wang, Ying Mao, Hui Yang, Ying Liu

Int J Biol Sci. 2024; 20(9): 3285–3301. Published online 2024 Jun 29. doi: 10.7150/ijbs.85672

PMCID:: PMC11234221

Abstract Article PDF–9.5M

Select item 111775182.

ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages

Xin Hua, Qiuli Xu, Ranpu Wu, Wei Sun, Yanli Gu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song

J Exp Clin Cancer Res. 2024; 43: 164. Published online 2024 Jun 14. doi: 10.1186/s13046-024-03073-0

PMCID:: PMC11177518

Abstract Article PDF–16M

Select item 111481843.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110940284.

ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p

Shouhua Wang, Xiang Zhu, Yuan Hao, Ting ting Su, Weibin Shi

Commun Biol. 2024; 7: 565. Published online 2024 May 14. doi: 10.1038/s42003-024-06274-7

PMCID:: PMC11094028

Abstract Article PDF–4.7M

Select item 110252185.

ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer

Yuanyuan An, Hua Duan

J Ovarian Res. 2024; 17: 84. Published online 2024 Apr 18. doi: 10.1186/s13048-024-01394-4

PMCID:: PMC11025218

Abstract Article PDF–3.0M

Select item 109292026.

ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m⁶A-dependent manner

Hanwen Wang, Shixin Zhao, Hengdeng Liu, Yiling Liu, Zihui Zhang, Ziheng Zhou, Peng Wang, Shaohai Qi, Julin Xie

Int J Biol Sci. 2024; 20(5): 1729–1743. Published online 2024 Feb 25. doi: 10.7150/ijbs.92994

PMCID:: PMC10929202

Abstract Article PDF–8.8M

Select item 108171757.

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome

Senko Tsukuda, James M. Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A.C. Wing, Jane A. McKeating

PLoS Pathog. 2024 Jan; 20(1): e1011917. Published online 2024 Jan 16. doi: 10.1371/journal.ppat.1011917

PMCID:: PMC10817175

Abstract Article PDF–2.5M

Select item 108029678.

The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis

Yujing Liu, Suihai Wang, Shanshan Wei, Xianwen Qiu, Yijie Mei, Lu Yan

PLoS One. 2024; 19(1): e0290986. Published online 2024 Jan 22. doi: 10.1371/journal.pone.0290986

PMCID:: PMC10802967

Abstract Article PDF–4.4M

Select item 107883399.

ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma

Yugeng Fan, Dujuan Yan, Lijun Ma, Xiaoxi Liu, Guoqiang Luo, Yan Hu, Xin Kou

Sci Rep. 2024; 14: 1303. Published online 2024 Jan 14. doi: 10.1038/s41598-024-51994-9

PMCID:: PMC10788339

Abstract Article PDF–8.3M

Select item 1077062710.

M⁶A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer

Xi Liu, Pan Li, Yuanfeng Huang, Hongsheng Li, Xin Liu, Yaxi Du, Xin Lin, Danyang Chen, Hao Liu, Yongchun Zhou

Redox Biol. 2024 Feb; 69: 102993. Published online 2023 Dec 12. doi: 10.1016/j.redox.2023.102993

PMCID:: PMC10770627

Abstract Article PDF–11M

Select item 1075771611.

The RNA m⁶A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

Yang Liu, Renjie Song, Zhike Lu, Lu Zhao, Xinyi Zhan, Yini Li, Xuetao Cao

Cell Mol Immunol. 2024 Jan; 21(1): 6–18. Published online 2023 Dec 20. doi: 10.1038/s41423-023-01115-9

PMCID:: PMC10757716

Abstract Article PDF–5.3M

Select item 1063660912.

ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m⁶A modification-mediated RNA stability control

Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha Patel, Wei Liu, Zhihong Qi, Yaping Li, Raman Nelakanti, Yuanbin Song, Giulia Biancon, Andrew Z. Xiao, Sarah Slavoff, Richard G. Kibbey, Richard A. Flavell, Matthew D. Simon, Toma Tebaldi, Hua-Bing Li, Stephanie Halene

Cell Rep. 2023 Oct 31; 42(10): 113163. Published online 2023 Sep 23. doi: 10.1016/j.celrep.2023.113163

PMCID:: PMC10636609

Abstract Article PDF–5.0M

Select item 1058803813.

ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner

Jinhao Chen, Mujie Ye, Jianan Bai, Zhihui Gong, Lijun Yan, Danyang Gu, Chunhua Hu, Feiyu Lu, Ping Yu, Lin Xu, Yan Wang, Ye Tian, Qiyun Tang

J Transl Med. 2023; 21: 741. Published online 2023 Oct 19. doi: 10.1186/s12967-023-04578-6

PMCID:: PMC10588038

Abstract Article PDF–12M

Select item 1058225714.

ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N ⁶-methyladenosine methylation

Long Bai, Yu Xiang, Minyue Tang, Shuangying Liu, Qingqing Chen, Qichao Chen, Min Zhang, Shan Wan, Yimiao Sang, Qingfang Li, Sisi Wang, Zhekun Li, Yang Song, Xiaoling Hu, Luna Mao, Guofang Feng, Long Cui, Yinghui Ye, Yimin Zhu

Nat Commun. 2023; 14: 6532. Published online 2023 Oct 17. doi: 10.1038/s41467-023-42302-6

PMCID:: PMC10582257

Abstract Article PDF–4.8M

Select item 1047428815.

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su, Dateng Li, Yunshu Che, Shuai Fan, Peng Wang, Yanfeng Wu, Huiyong Shen

Exp Mol Med. 2023 Aug; 55(8): 1743–1756. Published online 2023 Aug 1. doi: 10.1038/s12276-023-01059-0

PMCID:: PMC10474288

Abstract Article PDF–6.7M

Select item 1045745616.

The disordered C terminus of ALKBH5 promotes phase separation and paraspeckles assembly

Xiaoyang Qin, Yan Long, Xue Bai, Lei Cao, Han Yan, Kai Zhang, Bo Wang, Xudong Wu

J Biol Chem. 2023 Aug; 299(8): 105071. Published online 2023 Jul 18. doi: 10.1016/j.jbc.2023.105071

PMCID:: PMC10457456

Abstract Article PDF–3.5M

Select item 1042421217.

Deubiquitinase USP9X stabilizes RNA m⁶A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival

Peipei Wang, Jing Wang, Shuxin Yao, Manman Cui, Ying Cheng, Weidong Liu, Zhuying Gao, Jin Hu, Jinfang Zhang, Haojian Zhang

J Biol Chem. 2023 Aug; 299(8): 105055. Published online 2023 Jul 15. doi: 10.1016/j.jbc.2023.105055

PMCID:: PMC10424212

Abstract Article PDF–2.9M

Select item 1033083818.

RBM33 is a unique m⁶A RNA binding protein that regulates ALKBH5 Demethylase Activity and Substrate Selectivity

Fang Yu, Allen C Zhu, Shun Liu, Boyang Gao, Yuzhi Wang, Nelli Khudaverdyan, Chunjie Yu, Qiong Wu, Yunhan Jiang, Jikui Song, Lingtao Jin, Chuan He, Zhijian Qian

Mol Cell. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Mol Cell. 2023 Jun 15; 83(12): 2003–2019.e6. Published online 2023 May 30. doi: 10.1016/j.molcel.2023.05.010