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Select item 111439321.

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy

Qi Zhang, Sofia Bin, Kelly Budge, Astgik Petrosyan, Valentina Villani, Paola Aguiari, Coralien Vink, Jack Wetzels, Hasmik Soloyan, Gaetano La Manna, Manuel Alfredo Podestà, Paolo Molinari, Sargis Sedrakyan, Kevin V. Lemley, Roger E. De Filippo, Laura Perin, Paolo Cravedi, Stefano Da Sacco

JCI Insight. 2024 Feb 22; 9(4): e172976. Published online 2024 Jan 16. doi: 10.1172/jci.insight.172976

PMCID:: PMC11143932

Abstract Article PDF–7.3M

Select item 97561852.

Molecular signatures of intrarenal complement receptors C3AR1 and C5AR1 correlate with renal outcome in human lupus nephritis

Désirée Tampe, Samy Hakroush, Björn Tampe

Lupus Sci Med. 2022; 9(1): e000831. Published online 2022 Dec 15. doi: 10.1136/lupus-2022-000831

PMCID:: PMC9756185

Abstract Article PDF–1.2M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79733704.

Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism

Masaaki Ishii, Gyda Beeson, Craig Beeson, Bärbel Rohrer

Front Immunol. 2021; 12: 628062. Published online 2021 Mar 5. doi: 10.3389/fimmu.2021.628062

PMCID:: PMC7973370

Abstract Article PDF–9.2M

Select item 78714825.

High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels

Haibo Yang, Lin Li, Xiaoyu Liu, Yu Zhao

Med Sci Monit. 2021; 27: e927977-1–e927977-14. Prepublished online 2020 Dec 11. Published online 2021 Feb 4. doi: 10.12659/MSM.927977

PMCID:: PMC7871482

Abstract Article PDF–3.3M

Select item 76727236.

Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma

Bendong Chen, Wenyan Zhou, Chaofeng Tang, Genwang Wang, Peng Yuan, Yawen Zhang, Sah Chandra Bhushan, Jinlong Ma, Junzhi Leng

Technol Cancer Res Treat. 2020; 19: 1533033820970668. Published online 2020 Nov 11. doi: 10.1177/1533033820970668

PMCID:: PMC7672723

Abstract Article PDF–3.1M

Select item 69586747.

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

Chi Shu, Haoran Zha, Haixia Long, Xinxin Wang, Fei Yang, Jianbao Gao, Chunyan Hu, Li Zhou, Bo Guo, Bo Zhu

J Exp Clin Cancer Res. 2020; 39: 11. Published online 2020 Jan 13. doi: 10.1186/s13046-019-1515-2

PMCID:: PMC6958674

Abstract Article PDF–2.9M

Select item 68610868.

Deficiency of C3a receptor attenuates the development of diabetic nephropathy

Xiao-Qian Li, Dong-Yuan Chang, Min Chen, Ming-Hui Zhao

BMJ Open Diabetes Res Care. 2019; 7(1): e000817. Published online 2019 Nov 15. doi: 10.1136/bmjdrc-2019-000817

PMCID:: PMC6861086

Abstract Article PDF–2.9M

Select item 67571649.

The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor

Susanne Mommert, Derya Aslan, Lisanne Ratz, Holger Stark, Ralf Gutzmer, Thomas Werfel

J Innate Immun. 2018 Sep; 10(4): 349–362. Published online 2018 Jul 20. doi: 10.1159/000490426

PMCID:: PMC6757164

Abstract Article PDF–747K

Select item 675338110.

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

Bhavani S. Sahu, Pedro Rodriguez, Megin E. Nguyen, Ruijun Han, Cheryl Cero, Maria Razzoli, Paolo Piaggi, Lauren J. Laskowski, Mihaela Pavlicev, Louis Muglia, Sushil K. Mahata, Scott O’Grady, John D. McCorvy, Leslie J. Baier, Yuk Y. Sham, Alessandro Bartolomucci

Cell Rep. Author manuscript; available in PMC 2019 Sep 20.

Published in final edited form as: Cell Rep. 2019 Sep 3; 28(10): 2567–2580.e6. doi: 10.1016/j.celrep.2019.07.101

PMCID:: PMC6753381

Abstract Article PDF–1.7M

Select item 630920211.

Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer’s disease

Alexandra Litvinchuk, Ying-Wooi Wan, Dan B. Swartzlander, Fading Chen, Allysa Cole, Nicholas E. Propson, Qian Wang, Bin Zhang, Zhandong Liu, Hui Zheng

Neuron. Author manuscript; available in PMC 2019 Dec 19.

Published in final edited form as: Neuron. 2018 Dec 19; 100(6): 1337–1353.e5. Published online 2018 Nov 8. doi: 10.1016/j.neuron.2018.10.031

PMCID:: PMC6309202

Abstract Article PDF–3.8M

Select item 620224412.

A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis

Reinhard J. Sauter, Manuela Sauter, Edimara S. Reis, Frederic N. Emschermann, Henry Nording, Sonja Ebenhöch, Peter Kraft, Patrick Münzer, Maximilian Mauler, Johannes Rheinlaender, Johannes Madlung, Frank Edlich, Tilman E. Schäffer, Sven G. Meuth, Daniel Dürschmied, Tobias Geisler, Oliver Borst, Meinrad Gawaz, Christoph Kleinschnitz, John D. Lambris, Harald F. Langer

Circulation. Author manuscript; available in PMC 2019 Oct 16.

Published in final edited form as: Circulation. 2018 Oct 16; 138(16): 1720–1735. doi: 10.1161/CIRCULATIONAHA.118.034600

Correction in:: Circulation. 2019 Jan 15; 139(3): e8.

PMCID:: PMC6202244

Abstract Article PDF–1.1M

Select item 619252613.

Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells

Adrian J. Maurer, Phillip A. Bonney, Lucas C. Toho, Chad A. Glenn, Shweta Agarwal, James D. Battiste, Kar-Ming Fung, Michael E. Sughrue

Inflamm Res. Author manuscript; available in PMC 2018 Oct 17.

Published in final edited form as: Inflamm Res. 2015 Apr; 64(3-4): 185–192. Published online 2015 Jan 22. doi: 10.1007/s00011-015-0796-y

PMCID:: PMC6192526

Abstract Article PDF–961K

Select item 616594814.

Myocardial expression of the anaphylatoxin receptor C3aR is associated with cardiac inflammation and prognosis in patients with non‐ischaemic heart failure

Karin A.L. Mueller, Johannes Patzelt, Manuela Sauter, Philipp Maier, Sarah Gekeler, Karin Klingel, Reinhard Kandolf, Peter Seizer, Meinrad Gawaz, Tobias Geisler, Harald F. Langer

ESC Heart Fail. 2018 Oct; 5(5): 846–857. Published online 2018 Aug 31. doi: 10.1002/ehf2.12298

PMCID:: PMC6165948

Abstract Article PDF–962K

Select item 568613815.

Increased Complement 3a Receptor is Associated with Behcet’s disease and Vogt-Koyanagi-Harada disease

Chaokui Wang, Shuang Cao, Dike Zhang, Hong Li, Aize Kijlstra, Peizeng Yang

Sci Rep. 2017; 7: 15579. Published online 2017 Nov 14. doi: 10.1038/s41598-017-15740-8

PMCID:: PMC5686138

Abstract Article PDF–1.6M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 445464217.

Activation of C3a receptor is required in cigarette smoke-mediated emphysema

Xiaoyi Yuan, Ming Shan, Ran You, Michael V. Frazier, Monica Jeongsoo Hong, Rick A. Wetsel, Scott Drouin, Alexander Seryshev, Li-zhen Song MD, Lorraine Cornwell, Roger D Rossen, David B. Corry, Farrah Kheradmand

Mucosal Immunol. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Mucosal Immunol. 2015 Jul; 8(4): 874–885. Published online 2014 Dec 3. doi: 10.1038/mi.2014.118

PMCID:: PMC4454642

Abstract Article PDF–1.7M

Select item 435361318.

The TLQP-21 Peptide Activates the G-protein-coupled receptor C3aR1 via a Folding-upon-Binding Mechanism

Cheryl Cero, Vitaly V. Vostrikov, Raffaello Verardi, Cinzia Severini, Tata Gopinath, Patrick D. Braun, Maria F. Sassano, Allison Gurney, Bryan L. Roth, Lucy Vulchanova, Roberta Possenti, Gianluigi Veglia, Alessandro Bartolomucci

Structure. Author manuscript; available in PMC 2015 Dec 2.

Published in final edited form as: Structure. 2014 Dec 2; 22(12): 1744–1753. Published online 2014 Nov 13. doi: 10.1016/j.str.2014.10.001