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Items: 1 to 20 of 30

1.
HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350
Yuancai Lin, Hailong Gong, Jinliang Liu, Zhiwen Hu, Mingjun Gao, Wei Yu, Jing Liu
Cell Death Dis. 2023 Dec; 14(12): 794. Published online 2023 Dec 4. doi: 10.1038/s41419-023-06322-w
PMCID:
PMC10695927
AbstractArticlePDF–5.9M
2.
Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer
Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen
Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417
PMCID:
PMC10174091
AbstractArticlePDF–22M
3.
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1
Shanez Haouari, Christian Robert Andres, Debora Lanznaster, Sylviane Marouillat, Céline Brulard, Audrey Dangoumau, Devina Ung, Charlotte Veyrat-Durebex, Frédéric Laumonnier, Hélène Blasco, Philippe Couratier, Philippe Corcia, Patrick Vourc’h
Int J Mol Sci. 2023 Jan; 24(2): 1268. Published online 2023 Jan 9. doi: 10.3390/ijms24021268
PMCID:
PMC9867363
AbstractArticlePDF–1.2M
4.
Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma
Chao Wang, Keqin Dong, Yuning Wang, Guang Peng, Xu Song, Yongwei Yu, Pei Shen, Xingang Cui
BMC Cancer. 2021; 21: 890. Published online 2021 Aug 4. doi: 10.1186/s12885-021-08631-9
PMCID:
PMC8335872
AbstractArticlePDF–2.2M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118
PMCID:
PMC8017720
AbstractArticlePDF–1.9M
7.
The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system
Jia Liu, Su Dong, Lian Li, Heather Wang, Jing Zhao, Yutong Zhao
Cell Signal. Author manuscript; available in PMC 2020 Nov 2.
Published in final edited form as: Cell Signal. 2019 Jun; 58: 91–98. Published online 2019 Mar 5. doi: 10.1016/j.cellsig.2019.03.005
PMCID:
PMC7604857
AbstractArticlePDF–738K
8.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
9.
Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy
Youxia Liu, Jie Zheng, Junya Jia, Hongfen Li, Shuiyi Hu, Yujia Lin, Tiekun Yan
Ren Fail. 2019; 41(1): 370–376. Published online 2019 May 6. doi: 10.1080/0886022X.2019.1605295
PMCID:
PMC6508078
AbstractArticlePDF–714K
10.
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu
Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0
PMCID:
PMC5826926
AbstractArticlePDF–2.3M
11.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
12.
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes
Wei Zhang, Kuen-Phon Wu, Maria A. Sartori, Hari B. Kamadurai, Alban Ordureau, Chong Jiang, Peter Y. Mercredi, Ryan Murchie, Jicheng Hu, Avinash Persaud, Manjeet Mukherjee, Nan Li, Anne Doye, John R. Walker, Yi Sheng, Zhenyue Hao, Yanjun Li, Kevin R. Brown, Emmanuel Lemichez, Junjie Chen, Yufeng Tong, J. Wade Harper, Jason Moffat, Daniela Rotin, Brenda A. Schulman, Sachdev S. Sidhu
Mol Cell. Author manuscript; available in PMC 2017 Apr 7.
Published in final edited form as: Mol Cell. 2016 Apr 7; 62(1): 121–136. Published online 2016 Mar 3. doi: 10.1016/j.molcel.2016.02.005
PMCID:
PMC4988125
AbstractArticlePDF–1.2M
13.
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway
Hironori Inaba, Hidemasa Goto, Kousuke Kasahara, Kanako Kumamoto, Shigenobu Yonemura, Akihito Inoko, Shotaro Yamano, Hideki Wanibuchi, Dongwei He, Naoki Goshima, Tohru Kiyono, Shinji Hirotsune, Masaki Inagaki
J Cell Biol. 2016 Feb 15; 212(4): 409–423. doi: 10.1083/jcb.201507046
PMCID:
PMC4754717
AbstractArticlePDF–3.2M
14.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
15.
Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations
Yosua Adi Kristariyanto, Soo-Youn Choi, Syed Arif Abdul Rehman, Maria Stella Ritorto, David G Campbell, Nicholas A Morrice, Rachel Toth, Yogesh Kulathu
Biochem J. 2015 Apr 15; 467(Pt 2): 345–352. Published online 2015 Apr 2. doi: 10.1042/BJ20141502
PMCID:
PMC4390085
AbstractArticlePDF–1.0M
16.
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
Maggie C. Y. Ng, Daniel Shriner, Brian H. Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J. Bielinski, Lisa R. Yanek, Michael A. Nalls, Mary E. Comeau, Laura J. Rasmussen-Torvik, Richard A. Jensen, Daniel S. Evans, Yan V. Sun, Ping An, Sanjay R. Patel, Yingchang Lu, Jirong Long, Loren L. Armstrong, Lynne Wagenknecht, Lingyao Yang, Beverly M. Snively, Nicholette D. Palmer, Poorva Mudgal, Carl D. Langefeld, Keith L. Keene, Barry I. Freedman, Josyf C. Mychaleckyj, Uma Nayak, Leslie J. Raffel, Mark O. Goodarzi, Y-D Ida Chen, Herman A. Taylor, Jr., Adolfo Correa, Mario Sims, David Couper, James S. Pankow, Eric Boerwinkle, Adebowale Adeyemo, Ayo Doumatey, Guanjie Chen, Rasika A. Mathias, Dhananjay Vaidya, Andrew B. Singleton, Alan B. Zonderman, Robert P. Igo, Jr., John R. Sedor, the FIND Consortium, Edmond K. Kabagambe, David S. Siscovick, Barbara McKnight, Kenneth Rice, Yongmei Liu, Wen-Chi Hsueh, Wei Zhao, Lawrence F. Bielak, Aldi Kraja, Michael A. Province, Erwin P. Bottinger, Omri Gottesman, Qiuyin Cai, Wei Zheng, William J. Blot, William L. Lowe, Jennifer A. Pacheco, Dana C. Crawford, the eMERGE Consortium, the DIAGRAM Consortium, Elin Grundberg, the MuTHER Consortium, Stephen S. Rich, M. Geoffrey Hayes, Xiao-Ou Shu, Ruth J. F. Loos, Ingrid B. Borecki, Patricia A. Peyser, Steven R. Cummings, Bruce M. Psaty, Myriam Fornage, Sudha K. Iyengar, Michele K. Evans, Diane M. Becker, W. H. Linda Kao, James G. Wilson, Jerome I. Rotter, Michèle M. Sale, Simin Liu, Charles N. Rotimi, Donald W. Bowden, for the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium
PLoS Genet. 2014 Aug; 10(8): e1004517. Published online 2014 Aug 7. doi: 10.1371/journal.pgen.1004517
PMCID:
PMC4125087
AbstractArticlePDF–1.0M
17.
The HECT Type Ubiquitin Ligase NEDL2 Is Degraded by Anaphase-promoting Complex/Cyclosome (APC/C)-Cdh1, and Its Tight Regulation Maintains the Metaphase to Anaphase Transition
Li Lu, Shaohua Hu, Rongfei Wei, Xiao Qiu, Kefeng Lu, Yesheng Fu, Hongchang Li, Guichun Xing, Dong Li, Ruiyun Peng, Fuchu He, Lingqiang Zhang
J Biol Chem. 2013 Dec 13; 288(50): 35637–35650. Published online 2013 Oct 25. doi: 10.1074/jbc.M113.472076
PMCID:
PMC3861616
AbstractArticlePDF–4.4M
18.
A Genome-Wide Association Study Identifies New Susceptibility Loci for Esophageal Adenocarcinoma and Barrett’s Esophagus
David M. Levine, Weronica E. Ek, Rui Zhang, Xinxue Liu, Lynn Onstad, Cassandra Sather, Pierre Lao-Sirieix, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Liam J. Murray, Brian J. Reid, Wong-Ho Chow, Harvey A. Risch, Olof Nyrén, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, Alan G. Casson, Stephen Chanock, Patricia Harrington, Isabel Caldas, Irene Debiram-Beecham, Carlos Caldas, Nicholas K. Hayward, Paul Pharoah, Rebecca Fitzgerald, Stuart MacGregor, David C. Whiteman, Thomas L. Vaughan
Nat Genet. Author manuscript; available in PMC 2014 Jun 1.
Published in final edited form as: Nat Genet. 2013 Dec; 45(12): 1487–1493. Published online 2013 Oct 13. doi: 10.1038/ng.2796
PMCID:
PMC3840115
ArticlePDF–1.5M
19.
Cellular Localization and Characterization of Cytosolic Binding Partners for Gla Domain-containing Proteins PRRG4 and PRRG2
Mustafa N. Yazicioglu, Luca Monaldini, Kirk Chu, Fayaz R. Khazi, Samuel L. Murphy, Heshu Huang, Paris Margaritis, Katherine A. High
J Biol Chem. 2013 Sep 6; 288(36): 25908–25914. Published online 2013 Jul 19. doi: 10.1074/jbc.M113.484683
PMCID:
PMC3764795
AbstractArticlePDF–1.1M
20.
Genome Wide Association Study of the Rate of Cognitive Decline in Alzheimer’s Disease
Richard Sherva, Yorghos Tripodis, David Bennett, Lori B. Chibnik, Paul K. Crane, Philip de Jager, Lindsay A. Farrer, Andrew J. Saykin, Joshua Shulman, Robert C. Green, the Alzheimer’s Disease Neuroimaging Initiative
Alzheimers Dement. Author manuscript; available in PMC 2015 Jan 1.
Published in final edited form as: Alzheimers Dement. 2014 Jan; 10(1): 10.1016/j.jalz.2013.01.008. Published online 2013 Mar 25. doi: 10.1016/j.jalz.2013.01.008
PMCID:
PMC3760995
AbstractArticlePDF–589K

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