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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71791722.

Ginseng Gintonin Contains Ligands for GPR40 and GPR55

Yeon-Jin Cho, Sun-Hye Choi, Rami Lee, Hongik Hwang, Hyewhon Rhim, Ik-Hyun Cho, Hyoung-Chun Kim, Jeong-Ik Lee, Sung-Hee Hwang, Seung-Yeol Nah

Molecules. 2020 Mar; 25(5): 1102. Published online 2020 Mar 2. doi: 10.3390/molecules25051102

PMCID:: PMC7179172

Abstract Article PDF–4.5M

Select item 66201153.

Pharmacological stimulation of G–protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells

Aekkacha Moonwiriyakit, Michael Koval, Chatchai Muanprasat

Int Immunopharmacol. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Int Immunopharmacol. 2019 Aug; 73: 353–361. Published online 2019 May 23. doi: 10.1016/j.intimp.2019.05.026

PMCID:: PMC6620115

Abstract Article PDF–2.2M

Select item 65997344.

Upregulation of Free Fatty Acid Receptors in Periodontal Tissues of Patients with Metabolic Syndrome and Periodontitis

Guang Li, Samantha Robles, Zhongyang Lu, Yanchun Li, Joe W. Krayer, Renata S. Leite, DR. Yan Huang

J Periodontal Res. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: J Periodontal Res. 2019 Aug; 54(4): 356–363. Published online 2018 Dec 30. doi: 10.1111/jre.12636

PMCID:: PMC6599734

Abstract Article PDF–1.7M

Select item 64868255.

FFAR4 Is Involved in Regulation of Neurotensin Release From Neuroendocrine Cells and Male C57BL/6 Mice

Jing Li, Jun Song, Xian Li, Stephanie B Rock, Heather F Sinner, Heidi L Weiss, Todd Weiss, Courtney M Townsend, Jr, Tianyan Gao, B Mark Evers

Endocrinology. 2018 Aug; 159(8): 2939–2952. Published online 2018 May 22. doi: 10.1210/en.2018-00284

PMCID:: PMC6486825

Abstract Article

Select item 61926866.

GPR40 modulates epileptic seizure and NMDA receptor function

Yong Yang, Xin Tian, Demei Xu, Fangshuo Zheng, Xi Lu, Yanke Zhang, Yuanlin Ma, Yun Li, Xin Xu, Binglin Zhu, Xuefeng Wang

Sci Adv. 2018 Oct; 4(10): eaau2357. Published online 2018 Oct 17. doi: 10.1126/sciadv.aau2357

PMCID:: PMC6192686

Abstract Article PDF–4.5M

Select item 59170107.

Structural basis for GPR40 allosteric agonism and incretin stimulation

Joseph D. Ho, Betty Chau, Logan Rodgers, Frances Lu, Kelly L. Wilbur, Keith A. Otto, Yanyun Chen, Min Song, Jonathan P. Riley, Hsiu-Chiung Yang, Nichole A. Reynolds, Steven D. Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E. Madsen, Kris Conners, Jayana P. Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R. Lee, Jordi Benach, Kenton A. Baker, Chahrzad Montrose-Rafizadeh, Michael J. Genin, Anne R. Miller, Chafiq Hamdouchi

Nat Commun. 2018; 9: 1645. Published online 2018 Apr 25. doi: 10.1038/s41467-017-01240-w

PMCID:: PMC5917010

Abstract Article PDF–2.2M

Select item 58070078.

Palmitic Acid Hydroxy Stearic Acids Activate GPR40 Which is Involved in Their Beneficial Effects on Glucose Homeostasis

Ismail Syed, Jennifer Lee, Pedro M. Moraes-Vieira, Cynthia J. Donaldson, Alexandra Sontheimer, Pratik Aryal, Kerry Wellenstein, Matthew J Kolar, Andrew T Nelson, Dionicio Siegel, Jacek Mokrosinski, I. Sadaf Farooqi, Juan Juan Zhao, Mark M. Yore, Odile D. Peroni, Alan Saghatelian, Barbara B. Kahn

Cell Metab. Author manuscript; available in PMC 2019 Feb 6.

Published in final edited form as: Cell Metab. 2018 Feb 6; 27(2): 419–427.e4. doi: 10.1016/j.cmet.2018.01.001

PMCID:: PMC5807007

Abstract Article PDF–1.3M

Select item 57666079.

20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1

Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns

Nat Commun. 2018; 9: 177. Published online 2018 Jan 12. doi: 10.1038/s41467-017-02539-4

PMCID:: PMC5766607

Abstract Article PDF–1.2M

Select item 549854310.

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

H. Kristinsson, E. Sargsyan, H. Manell, D. M. Smith, S. O. Göpel, P. Bergsten

Sci Rep. 2017; 7: 4657. Published online 2017 Jul 5. doi: 10.1038/s41598-017-04730-5

PMCID:: PMC5498543

Abstract Article PDF–1.6M

Select item 482172711.

Linoleic Acid Permeabilizes Gastric Epithelial Cells by Increasing Connexin43 Levels in the Cell Membrane Via a GPR40- and Akt-Dependent Mechanism

Carlos Puebla, Bruno A. Cisterna, Daniela P. Salas, Fernando Delgado-López, Paul D. Lampe, Juan C. Sáez

Biochim Biophys Acta. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Biochim Biophys Acta. 2016 May; 1861(5): 439–448. Published online 2016 Feb 8. doi: 10.1016/j.bbalip.2016.02.002

PMCID:: PMC4821727

Abstract Article PDF–588K

Select item 462898112.

Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle

Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, Charles W. Emala, Sr.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1; 309(9): L970–L982. Published online 2015 Sep 4. doi: 10.1152/ajplung.00041.2015

PMCID:: PMC4628981

Abstract Article

Select item 462470813.

A Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor Function

Shimeng Guo, Jiandong Zhang, Shuyong Zhang, Jing Li

PLoS One. 2015; 10(10): e0141303. Published online 2015 Oct 27. doi: 10.1371/journal.pone.0141303

PMCID:: PMC4624708

Abstract Article PDF–2.0M

Select item 454366914.

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1

Arturo D. Mancini, Gyslaine Bertrand, Kevin Vivot, Éric Carpentier, Caroline Tremblay, Julien Ghislain, Michel Bouvier, Vincent Poitout

J Biol Chem. 2015 Aug 21; 290(34): 21131–21140. Published online 2015 Jul 8. doi: 10.1074/jbc.M115.644450

PMCID:: PMC4543669

Abstract Article PDF–1.7M

Select item 452812215.

G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY

Shuibang Wang, Keytam S. Awad, Jason M. Elinoff, Edward J. Dougherty, Gabriela A. Ferreyra, Jennifer Y. Wang, Rongman Cai, Junfeng Sun, Anetta Ptasinska, Robert L. Danner

J Biol Chem. 2015 Aug 7; 290(32): 19544–19557. Published online 2015 Jun 23. doi: 10.1074/jbc.M115.638924

PMCID:: PMC4528122

Abstract Article PDF–4.5M

Select item 450036416.

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

G Milligan, E Alvarez-Curto, K R Watterson, T Ulven, B D Hudson

Br J Pharmacol. 2015 Jul; 172(13): 3254–3265. Published online 2015 Feb 27. doi: 10.1111/bph.12879

PMCID:: PMC4500364

Abstract Article PDF–732K

Select item 439718617.

GPR40/FFA1 and Neutral Sphingomyelinase Are Involved in Palmitate-Boosted Inflammatory Response of Microvascular Endothelial Cells to LPS

Zhongyang Lu, Yanchun Li, Junfei Jin, Xiaoming Zhang, Yusuf A. Hannun, Yan Huang

Atherosclerosis. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Atherosclerosis. 2015 May; 240(1): 163–173. Published online 2015 Mar 14. doi: 10.1016/j.atherosclerosis.2015.03.013

PMCID:: PMC4397186

Abstract Article PDF–1.4M

Select item 433247118.

Overexpression of G-Protein-Coupled Receptor 40 Enhances the Mitogenic Response to Epoxyeicosatrienoic Acids

Seong Kwon Ma, Yinqiu Wang, Jianchun Chen, Ming-Zhi Zhang, Raymond C. Harris, Jian-Kang Chen

PLoS One. 2015; 10(2): e0113130. Published online 2015 Feb 13. doi: 10.1371/journal.pone.0113130

PMCID:: PMC4332471

Abstract Article PDF–1.0M

Select item 414093019.

Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice: A ROLE FOR GPR120 IN GLUCAGON SECRETION

Arthur T. Suckow, David Polidori, Wen Yan, Suhyoun Chon, Jing Ying Ma, James Leonard, Celia P. Briscoe

J Biol Chem. 2014 May 30; 289(22): 15751–15763. Published online 2014 Apr 17. doi: 10.1074/jbc.M114.568683

PMCID:: PMC4140930

Abstract Article PDF–4.2M

Select item 379492720.

A Novel Antidiabetic Drug, Fasiglifam/TAK-875, Acts as an Ago-Allosteric Modulator of FFAR1

Chiori Yabuki, Hidetoshi Komatsu, Yoshiyuki Tsujihata, Risa Maeda, Ryo Ito, Kae Matsuda-Nagasumi, Kensuke Sakuma, Kazumasa Miyawaki, Naoya Kikuchi, Koji Takeuchi, Yugo Habata, Masaaki Mori

PLoS One. 2013; 8(10): e76280. Published online 2013 Oct 10. doi: 10.1371/journal.pone.0076280

PMCID:: PMC3794927

Abstract Article PDF–1.5M

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Organophosphorus compound VX effect on hepatocytes: dose response
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