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Select item 110717571.

DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis

Amina Jamal Laham, Maha Saber-Ayad, Raafat El-Awady

Cell Mol Life Sci. 2021 Jan; 78(2): 603–619. Published online 2020 Sep 1. doi: 10.1007/s00018-020-03626-4

PMCID:: PMC11071757

Abstract Article PDF–1.6M

Select item 110175622.

Shared and divergent mental health characteristics of ADNP-, CHD8- and DYRK1A-related neurodevelopmental conditions

Emily Neuhaus, Hannah Rea, Elizabeth Jones, Hannah Benavidez, Conor Miles, Alana Whiting, Margaret Johansson, Curtis Eayrs, Evangeline C. Kurtz-Nelson, Rachel Earl, Raphael A. Bernier, Evan E. Eichler

J Neurodev Disord. 2024; 16: 15. Published online 2024 Apr 15. doi: 10.1186/s11689-024-09532-1

PMCID:: PMC11017562

Abstract Article PDF–1.2M

Select item 109523933.

Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders

Elizabeth K. J. Hogg, Greg M. Findlay

FEBS Lett. 2023 Oct; 597(19): 2375–2415. Published online 2023 Sep 4. doi: 10.1002/1873-3468.14723

PMCID:: PMC10952393

Abstract Article PDF–1.9M

Select item 109457074.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109248445.

MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang, Hongfeng Chang, Wenyang Chen, Taotao Fan, Lesha Zhang, Bing Shen, Qiu Zhang

Commun Biol. 2024; 7: 300. Published online 2024 Mar 9. doi: 10.1038/s42003-024-05986-0

PMCID:: PMC10924844

Abstract Article PDF–18M

Select item 108959986.

Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis

Ying Ting Sit, Kaoru Takasaki, Hyun Hyung An, Yan Xiao, Christian Hurtz, Peter A. Gearhart, Zhe Zhang, Paul Gadue, Deborah L. French, Stella T. Chou

JCI Insight. 2023 Dec 8; 8(23): e172851. Published online 2023 Oct 31. doi: 10.1172/jci.insight.172851

PMCID:: PMC10895998

Abstract Article PDF–1.9M

Select item 108132067.

Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation

Chiara Di Vona, Laura Barba, Roberto Ferrari, Susana de la Luna

Biomolecules. 2024 Jan; 14(1): 31. Published online 2023 Dec 25. doi: 10.3390/biom14010031

PMCID:: PMC10813206

Abstract Article PDF–2.9M

Select item 108050188.

DYRK1A is a multifunctional host factor that regulates coronavirus replication in a kinase-independent manner

Zhen Fu, Yixin Xiang, Yanan Fu, Zhelin Su, Yubei Tan, Mengfang Yang, Yuanyuan Yan, Hakimeh Baghaei Daemi, Yuejun Shi, Shengsong Xie, Limeng Sun, Guiqing Peng

J Virol. 2024 Jan; 98(1): e01239-23. Published online 2023 Dec 15. doi: 10.1128/jvi.01239-23

PMCID:: PMC10805018

Abstract Article PDF–5.0M

Select item 105592289.

Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A

Yoshihiko Miyata, Eisuke Nishida

Life Sci Alliance. 2023 Dec; 6(12): e202302129. Published online 2023 Oct 6. doi: 10.26508/lsa.202302129

PMCID:: PMC10559228

Abstract Article PDF–3.6M

Select item 1053055910.

Characterizing the autism spectrum phenotype in DYRK1A-related syndrome

Evangeline C. Kurtz-Nelson, Hannah M. Rea, Aiva C. Petriceks, Caitlin M. Hudac, Tianyun Wang, Rachel K. Earl, Raphael A. Bernier, Evan E. Eichler, Emily Neuhaus

Autism Res. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Autism Res. 2023 Aug; 16(8): 1488–1500. Published online 2023 Jul 27. doi: 10.1002/aur.2995

PMCID:: PMC10530559

Abstract Article PDF–644K

Select item 1043576711.

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Dražen J. Petrović, Ana Bekavac, Ante Plećaš, Valentina Hribljan, Reinhard Brunmeir, Julija Jurić, Maja Pučić-Baković, Anita Slana, Helena Deriš, Azra Frkatović, Jűrgen Groet, Niamh L. O’Brien, Hong Yu Chen, Yee Jie Yeap, Frederic Delom, Steven Havlicek, Luke Gammon, Sarah Hamburg, Carla Startin, Hana D’Souza, Dinko Mitrečić, Mijana Kero, Ljubica Odak, Božo Krušlin, Željka Krsnik, Ivica Kostović, Jia Nee Foo, Yuin-Han Loh, Norris Ray Dunn, Susana de la Luna, Tim Spector, Ingeborg Barišić, Michael S.C. Thomas, Andre Strydom, Claudio Franceschi, Gordan Lauc, Jasminka Krištić, Ivan Alić, Dean Nižetić

eBioMedicine. 2023 Aug; 94: 104692. Published online 2023 Jul 12. doi: 10.1016/j.ebiom.2023.104692

PMCID:: PMC10435767

Abstract Article PDF–4.3M

Select item 1033919612.

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21

François Bélanger, Cassandra Roussel, Christina Sawchyn, Edlie St-Hilaire, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Frédérick Antoine Mallette, Hugo Wurtele, Elliot Drobetsky

J Biol Chem. 2023 Jul; 299(7): 104900. Published online 2023 Jun 9. doi: 10.1016/j.jbc.2023.104900

PMCID:: PMC10339196

Abstract Article PDF–2.2M

Select item 1026335613.

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

Madison S. Strine, Wesley L. Cai, Jin Wei, Mia Madel Alfajaro, Renata B. Filler, Scott B. Biering, Sylvia Sarnik, Ryan D. Chow, Ajinkya Patil, Kasey S. Cervantes, Clayton K. Collings, Peter C. DeWeirdt, Ruth E. Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G. Doench, Patrick D. Hsu, Cigall Kadoch, Qin Yan, Craig B. Wilen

PLoS Biol. 2023 Jun; 21(6): e3002097. Published online 2023 Jun 13. doi: 10.1371/journal.pbio.3002097

PMCID:: PMC10263356

Abstract Article PDF–2.6M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1007290615.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1002542516.

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage

Cell Genom. 2023 Mar 8; 3(3): 100250. Published online 2023 Jan 24. doi: 10.1016/j.xgen.2022.100250

PMCID:: PMC10025425

Abstract Article PDF–22M

Select item 995367817.

The Conserved Transcriptional Activation Activity Identified in Dual-Specificity Tyrosine-(Y)-Phosphorylation-Regulated Kinase 1

Xiuke Ouyang, Zhuqing Wang, Bingtong Wu, Xiuxia Yang, Bo Dong

Biomolecules. 2023 Feb; 13(2): 283. Published online 2023 Feb 2. doi: 10.3390/biom13020283

PMCID:: PMC9953678

Abstract Article PDF–3.5M

Select item 995018318.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 952511819.

Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Kamaleldin E. Elagib, Ashton Brock, Cara M. Clementelli, Goar Mosoyan, Lorrie L. Delehanty, Ranjit K. Sahu, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, Stephan W. Morris, Koji Eto, Chintan Jobaliya, Deborah L. French, Paul Gadue, Sandeep Singh, Xinrui Shi, Fujun Qin, Robert Cornelison, Hui Li, Camelia Iancu-Rubin, Adam N. Goldfarb

J Clin Invest. 2022 Oct 3; 132(19): e154839. Published online 2022 Oct 3. doi: 10.1172/JCI154839