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Select item 101156291.

Structural basis for GSDMB pore formation and its targeting by IpaH7.8

Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma, JengYih Chang, Kunpeng Li, Kangkang Song, Chen Xu, Vijay A. Rathinam, Jianbin Ruan

Nature. 2023; 616(7957): 590–597. Published online 2023 Mar 29. doi: 10.1038/s41586-023-05832-z

PMCID:: PMC10115629

Abstract Article PDF–49M

Select item 98214182.

The study of GSDMB in pathogenesis of psoriasis vulgaris

Xiaojuan Ji, Huaqing Chen, Ling Xie, Shiqi Chen, Shan Huang, Qi Tan, Huifang Yang, Tao Yang, Xiaoying Ye, Zhaolin Zeng, Chunlei Wan, Longnian Li

PLoS One. 2023; 18(1): e0279908. Published online 2023 Jan 6. doi: 10.1371/journal.pone.0279908

PMCID:: PMC9821418

Abstract Article PDF–963K

Select item 98133583.

Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8

Hang Yin, Jian Zheng, Qiuqiu He, Xuan Zhang, Xuzichao Li, Yongjian Ma, Xiao Liang, Jiaqi Gao, Benjamin L. Kocsis, Zhuang Li, Xiang Liu, Neal M. Alto, Long Li, Heng Zhang

Nat Commun. 2023; 14: 61. Published online 2023 Jan 4. doi: 10.1038/s41467-022-35725-0

PMCID:: PMC9813358

Abstract Article PDF–2.8M

Select item 95366114.

GSDM gene polymorphisms regulate the IgE level in asthmatic patients

Amer Imraish, Tuqa Abu-Thiab, Tareq Alhindi, Malek Zihlif

PLoS One. 2022; 17(10): e0274951. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0274951

PMCID:: PMC9536611

Abstract Article PDF–401K

Select item 88799975.

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro

Cell. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Cell. 2022 Jan 20; 185(2): 283–298.e17. Published online 2022 Jan 11. doi: 10.1016/j.cell.2021.12.024

Correction in:: Cell. 2024 Feb 15; 187(4): 1011–1015.

PMCID:: PMC8879997

Abstract Article PDF–4.8M

Select item 87023406.

Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis

Yuanshan Cui, Zhongbao Zhou, Yumeng Chai, Yong Zhang

J Immunol Res. 2021; 2021: 7753553. Published online 2021 Dec 16. doi: 10.1155/2021/7753553

PMCID:: PMC8702340

Abstract Article PDF–4.7M

Select item 86365137.

The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.

Dana E. Zack, Debra A. Stern, Amanda L. Willis, Alexander S. Kim, Corinne J. Mansfield, Danielle R. Reed, Steven G. Brooks, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Alexander G. Chiu, Brian H. Song, Chris H. Le, Eugene H. Chang

Int Forum Allergy Rhinol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Int Forum Allergy Rhinol. 2021 Dec; 11(12): 1647–1653. Published online 2021 Jun 2. doi: 10.1002/alr.22824

PMCID:: PMC8636513

Abstract Article PDF–327K

Select item 83150278.

USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway

Haiqing He, Lu Yi, Bin Zhang, Bin Yan, Ming Xiao, Jiannan Ren, Dong Zi, Liang Zhu, Zhaohui Zhong, Xiaokun Zhao, Xin Jin, Wei Xiong

Int J Biol Sci. 2021; 17(10): 2417–2429. Published online 2021 Jun 11. doi: 10.7150/ijbs.54442

PMCID:: PMC8315027

Abstract Article PDF–3.3M

Select item 82215299.

Pathogenic Ubiquitination of GSDMB Inhibits NK-cell Bactericidal Functions.

Justin M. Hansen, Maarten F. de Jong, Qi Wu, Li-Shu Zhang, David B. Heisler, Laura T. Alto, Neal M. Alto

Cell. Author manuscript; available in PMC 2022 Jun 10.

Published in final edited form as: Cell. 2021 Jun 10; 184(12): 3178–3191.e18. Published online 2021 May 21. doi: 10.1016/j.cell.2021.04.036

PMCID:: PMC8221529

Abstract Article PDF–2.0M

Select item 801918110.

Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case–control study

Yu Zhang, Li Hua, Quan-Hua Liu, Shu-Yuan Chu, Yue-Xin Gan, Min Wu, Yi-Xiao Bao, Qian Chen, Jun Zhang

BMC Pulm Med. 2021; 21: 114. Published online 2021 Apr 2. doi: 10.1186/s12890-021-01484-9

PMCID:: PMC8019181

Abstract Article PDF–838K

Select item 787616711.

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

Xingnan Li, Stephanie A. Christenson, Brian Modena, Huashi Li, William W. Busse, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Benjamin Gaston, Annette T. Hastie, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Wendy C. Moore, Prescott G. Woodruff, Naftali Kaminski, Sally E. Wenzel, Eugene R. Bleecker, Deborah A. Meyers

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Mar; 147(3): 894–909. Published online 2020 Aug 11. doi: 10.1016/j.jaci.2020.07.030

PMCID:: PMC7876167

Abstract Article PDF–807K

Select item 673449112.

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

Qin Chen, Peiliang Shi, Yufang Wang, Dayuan Zou, Xiuwen Wu, Dingyu Wang, Qiongyuan Hu, Yujie Zou, Zan Huang, Jianan Ren, Zhaoyu Lin, Xiang Gao

J Mol Cell Biol. 2019 Jun; 11(6): 496–508. Published online 2018 Oct 15. doi: 10.1093/jmcb/mjy056

PMCID:: PMC6734491

Abstract Article PDF–1.2M

Select item 603762013.

A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

Ronald A. Panganiban, Maoyun Sun, Amber Dahlin, Hae-Ryung Park, Mengyuan Kan, Blanca E. Himes, Jennifer A. Mitchel, Carlos Iribarren, Eric Jorgenson, Scott H. Randell, Elliot Israel, Kelan Tantisira, Stephanie Shore, Jin-Ah Park, Scott T. Weiss, Ann Chen Wu, Quan Lu

J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Nov 9.

Published in final edited form as: J Allergy Clin Immunol. 2018 Nov; 142(5): 1469–1478.e2. Published online 2018 Jan 9. doi: 10.1016/j.jaci.2017.11.040

PMCID:: PMC6037620

Abstract Article PDF–1.3M

Select item 599418514.

The role of local CpG DNA methylation in mediating the 17q21 asthma-susceptibility GSDMB/ORMDL3 expression quantitative trait locus

Parul H. Kothari, Weiliang Qiu, Damien C. Croteau-Chonka, Fernando D. Martinez, Andrew H. Liu, Robert F. Lemanske, Jr., Carole Ober, Jerry A. Krishnan, Dan L. Nicolae, Kathleen C. Barnes, Stephanie J. London, Albino Barraza-Villarreal, Steven R. White, Edward T. Naureckas, Joshua Millstein, W. James Gauderman, Frank D. Gilliland, Vincent J. Carey, Scott T. Weiss, Benjamin A. Raby, On behalf of the Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium

J Allergy Clin Immunol. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: J Allergy Clin Immunol. 2018 Jun; 141(6): 2282–2286.e6. Published online 2018 Jan 31. doi: 10.1016/j.jaci.2017.11.057

PMCID:: PMC5994185

Article PDF–215K

Select item 546019815.

Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis

Yuki Hitomi, Kaname Kojima, Minae Kawashima, Yosuke Kawai, Nao Nishida, Yoshihiro Aiba, Michio Yasunami, Masao Nagasaki, Minoru Nakamura, Katsushi Tokunaga

Sci Rep. 2017; 7: 2904. Published online 2017 Jun 6. doi: 10.1038/s41598-017-03067-3

PMCID:: PMC5460198

Abstract Article PDF–1.7M

Select item 537259216.

The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis

Giulia Cardamone, Elvezia Maria Paraboschi, Valeria Rimoldi, Stefano Duga, Giulia Soldà, Rosanna Asselta

Int J Mol Sci. 2017 Mar; 18(3): 576. Published online 2017 Mar 7. doi: 10.3390/ijms18030576

PMCID:: PMC5372592

Abstract Article PDF–1.4M

Select item 535552417.

Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression

Anna Lutkowska, Andrzej Roszak, Margarita Lianeri, Anna Sowińska, Emianka Sotiri, Pawel P. Jagodziński

Mol Diagn Ther. 2017; 21(2): 199–207. Published online 2017 Jan 25. doi: 10.1007/s40291-017-0256-1

PMCID:: PMC5355524

Abstract Article PDF–470K

Select item 532103318.

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

Kinlin L. Chao, Liudmila Kulakova, Osnat Herzberg

Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): E1128–E1137. Published online 2017 Feb 1. doi: 10.1073/pnas.1616783114

PMCID:: PMC5321033

Abstract Article PDF–2.1M

Select item 530291519.

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer

Marta Hergueta-Redondo, David Sarrio, Ángela Molina-Crespo, Rocío Vicario, Cristina Bernadó-Morales, Lidia Martínez, Alejandro Rojo-Sebastián, Jordi Serra-Musach, Alba Mota, Ángel Martínez-Ramírez, Maria Ángeles Castilla, Antonio González-Martin, Sonia Pernas, Amparo Cano, Javier Cortes, Paolo G. Nuciforo, Vicente Peg, José Palacios, Miguel Ángel Pujana, Joaquín Arribas, Gema Moreno-Bueno

Oncotarget. 2016 Aug 30; 7(35): 56295–56308. Published online 2016 Jul 22. doi: 10.18632/oncotarget.10787

PMCID:: PMC5302915

Abstract Article PDF–6.8M

Select item 513537820.

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Sudipta Das, Marina Miller, Andrew K. Beppu, James Mueller, Matthew D. McGeough, Christine Vuong, Maya R. Karta, Peter Rosenthal, Fazila Chouiali, Taylor A. Doherty, Richard C. Kurten, Qutayba Hamid, Hal M. Hoffman, David H. Broide

Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46): 13132–13137. Published online 2016 Oct 31. doi: 10.1073/pnas.1610433113

PMCID:: PMC5135378

Abstract Article PDF–1.0M

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PMC Links for GEO Profiles (Select 81651551) (48)
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Asthma exacerbation and convalescent phases: peripheral blood mononuclear cells
Asthma exacerbation and convalescent phases: peripheral blood mononuclear cells
Accession: GDS3615

GEO DataSets
Related DataSets for GEO Profiles (Select 62373692) (1)
GEO DataSets
Osteoarthritic chondrocytes: monolayer and matrix cultures
Osteoarthritic chondrocytes: monolayer and matrix cultures
Accession: GDS3758

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Related DataSets for GEO Profiles (Select 67023123) (1)
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