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Select item 111099451.

WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination

Jie Zhang, Yuanyuan Yu, Xiuqun Zou, Yaning Du, Qiankun Liang, Mengyao Gong, Yurong He, Junqi Luo, Dandan Wu, Xiaoli Jiang, Matt Sinclair, Emad Tajkhorshid, Hong-Zhuan Chen, Zhaoyuan Hou, Yuejuan Zheng, Lin-Feng Chen, Xiao-Dong Yang

Nucleic Acids Res. 2024 May 22; 52(9): 4969–4984. Published online 2024 Mar 7. doi: 10.1093/nar/gkae161

PMCID:: PMC11109945

Abstract Article PDF–1.6M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104544983.

WSB1 Involvement in Prostate Cancer Progression

Laura Boldrini, Massimo Bardi

Genes (Basel) 2023 Aug; 14(8): 1558. Published online 2023 Jul 29. doi: 10.3390/genes14081558

PMCID:: PMC10454498

Abstract Article PDF–785K

Select item 100703444.

PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions

Jiayi Chen, Mei Li, Yeqing Liu, Tangming Guan, Xiao Yang, Yalei Wen, Yingjie Zhu, Zeyu Xiao, Xiangchun Shen, Haoxing Zhang, Hui Tang, Tongzheng Liu

Cell Death Differ. 2023 Apr; 30(4): 1082–1095. Published online 2023 Feb 23. doi: 10.1038/s41418-023-01128-x

PMCID:: PMC10070344

Abstract Article PDF–5.0M

Select item 90722315.

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao

Acta Pharm Sin B. 2022 Mar; 12(3): 1225–1239. Published online 2021 Oct 26. doi: 10.1016/j.apsb.2021.10.021

PMCID:: PMC9072231

Abstract Article PDF–2.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79377247.

WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides

Valdirene Leão Carneiro, Hugo Bernardino Ferreira da Silva, Gerson de Almeida Queiroz, Rafael Valente Veiga, Pablo Rafael Silveira Oliveira, Norma Vilany Queiroz Carneiro, Anaque de Oliveira Pires, Raimon Rios da Silva, Flavia Sena, Emilia Belitardo, Regina Nascimento, Milca Silva, Cintia Rodrigues Marques, Ryan dos Santos Costa, Neuza Maria Alcantra-Neves, Mauricio L. Barreto, Philip J. Cooper, Camila Alexandrina Figueiredo

Front Immunol. 2021; 12: 622051. Published online 2021 Feb 22. doi: 10.3389/fimmu.2021.622051

PMCID:: PMC7937724

Abstract Article PDF–1009K

Select item 75668818.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 71752499.

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Xinxin Liu, Xiaoli Zhang, Zhiqiang Peng, Chunnan Li, Ze Wang, Chanjuan Wang, Zhikang Deng, Bo Wu, Yu Cui, Zhanxin Wang, Chun‐Ping Cui, Min Zheng, Lingqiang Zhang

Adv Sci (Weinh) 2020 Apr; 7(8): 1902040. Published online 2020 Mar 8. doi: 10.1002/advs.201902040

PMCID:: PMC7175249

Abstract Article PDF–4.0M

Select item 715369510.

ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.

Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008

PMCID:: PMC7153695

Abstract Article PDF–2.6M

Select item 671347511.

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne JG Chan, Samir Kharbanda, Jonathon J O'Brien, Fiona E McAllister, Ari J Firestone, Calvin H Jan, Jeffrey Settleman

eLife. 2019; 8: e47362. Published online 2019 Aug 27. doi: 10.7554/eLife.47362

PMCID:: PMC6713475

Abstract Article PDF–4.6M

Select item 603950112.

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Ming-Shan Niu, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Kai-Lin Xu

Cell Death Dis. 2018 Jul; 9(7): 774. Published online 2018 Jul 10. doi: 10.1038/s41419-018-0812-6

PMCID:: PMC6039501

Abstract Article PDF–2.7M

Select item 594353513.

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer

Flore-Anne Poujade, Aarren Mannion, Nicholas Brittain, Andrew Theodosi, Ellie Beeby, Katarzyna B. Leszczynska, Ester M. Hammond, John Greenman, Christopher Cawthorne, Isabel M. Pires

Br J Cancer. 2018 May 1; 118(9): 1229–1237. Published online 2018 Mar 15. doi: 10.1038/s41416-018-0056-3

PMCID:: PMC5943535

Abstract Article PDF–1.4M

Select item 567858114.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533985016.

WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Jung Jin Kim, Seung Baek Lee, Sang-Yeop Yi, Sang-Ah Han, Sun-Hyun Kim, Jong-Min Lee, Seo-Yun Tong, Ping Yin, Bowen Gao, Jun Zhang, Zhenkun Lou

Cell Res. 2017 Feb; 27(2): 274–293. Published online 2016 Dec 13. doi: 10.1038/cr.2016.148

PMCID:: PMC5339850

Abstract Article PDF–7.2M

Select item 508522617.

miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth

Yan-Yan Jia, Jin-Yi Zhao, Bing-Ling Li, Kai Gao, Ying Song, Mei-You Liu, Xiao-Juan Yang, Yan Xue, Ai-Dong Wen, Lei Shi

Oncotarget. 2016 Jun 7; 7(23): 35257–35269. Published online 2016 May 2. doi: 10.18632/oncotarget.9135

PMCID:: PMC5085226

Abstract Article PDF–7.9M

Select item 499221618.

WSB1: from homeostasis to hypoxia

Moinul Haque, Joseph Keith Kendal, Ryan Matthew MacIsaac, Douglas James Demetrick

J Biomed Sci. 2016; 23: 61. Published online 2016 Aug 19. doi: 10.1186/s12929-016-0270-3

PMCID:: PMC4992216

Abstract Article PDF–1.5M

Select item 489963019.

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

Frederick C. Nucifora, Jr, Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani, Simone Engelender, Dong Wei, Xiao-Fang Wang, Tianxia Li, Darren J. Moore, Olga Pletnikova, Juan C. Troncoso, Akira Sawa, Ted M. Dawson, Wanli Smith, Kah-Leong Lim, Christopher A. Ross

Nat Commun. 2016; 7: 11792. Published online 2016 Jun 7. doi: 10.1038/ncomms11792

PMCID:: PMC4899630

Abstract Article PDF–1.3M

Select item 464794120.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

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