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Select item 111458051.

NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression

Yijun Shi, Na Fang, Yutong Wu, Huiwen Xu, Anhui Ning, Wendi Zhang, Yiran Liu, Xiaobo Tao, Qiong Chen, Tian Tian, Lei Zhang, Minjie Chu, Jiahua Cui

Cell Commun Signal. 2024; 22: 302. Published online 2024 Jun 3. doi: 10.1186/s12964-024-01685-9

PMCID:: PMC11145805

Abstract Article PDF–17M

Select item 109621282.

NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells

Binghong Liu, Fei Song, Xiaoxia Zhou, Chan Wu, Huizhu Huang, Weiyin Wu, Gang Li, Yan Wang

J Cell Mol Med. 2024 Apr; 28(8): 1–11. Published online 2024 Mar 25. doi: 10.1111/jcmm.18233

PMCID:: PMC10962128

Abstract Article PDF–17M

Select item 109457073.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109335554.

NEDD4L intramolecular interactions regulate its auto and substrate Na_V1.5 ubiquitination

Katharine M. Wright, Sara Nathan, Hanjie Jiang, Wendy Xia, HyoJeon Kim, Nourdine Chakouri, Justin N. Nwafor, Lucile Fossier, Lakshmi Srinivasan, Zan Chen, Tatiana Boronina, Jeremy Post, Suman Paul, Robert N. Cole, Manu Ben-Johny, Philip A. Cole, Sandra B. Gabelli

J Biol Chem. 2024 Mar; 300(3): 105715. Published online 2024 Feb 2. doi: 10.1016/j.jbc.2024.105715

PMCID:: PMC10933555

Abstract Article PDF–5.1M

Select item 108346165.

METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke

Wenjie Su, Xiang Yu, Shan Wang, Xu Wang, Zheng Dai, Yi Li

Cell Biol Toxicol. 2024; 40(1): 8. Published online 2024 Feb 2. doi: 10.1007/s10565-024-09844-x

PMCID:: PMC10834616

Abstract Article PDF–7.0M

Select item 104243986.

The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen, Ming-Hsien Chien

J Biomed Sci. 2023; 30: 68. Published online 2023 Aug 14. doi: 10.1186/s12929-023-00949-9

PMCID:: PMC10424398

Abstract Article PDF–6.4M

Select item 103372847.

Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary

Juan Liu, Jihong Hu, Yaqing Duan, Rong Qin, Chunguang Guo, Hongtao Zhou, Hua Liu, Chunlei Liu

Mol Genet Genomic Med. 2023 Jul; 11(7): e2169. Published online 2023 Mar 19. doi: 10.1002/mgg3.2169

PMCID:: PMC10337284

Abstract Article PDF–1.8M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102183539.

JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis

Kun Ding, Xuqian Jiang, Zhangding Wang, Lu Zou, Jiahua Cui, Xiong Li, Chuanjun Shu, Aiping Li, Jianwei Zhou

Int J Mol Sci. 2023 May; 24(10): 8794. Published online 2023 May 15. doi: 10.3390/ijms24108794

PMCID:: PMC10218353

Abstract Article PDF–19M

Select item 1018550010.

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu

Cell Death Discov. 2023; 9: 165. Published online 2023 May 15. doi: 10.1038/s41420-023-01463-5

PMCID:: PMC10185500

Abstract Article PDF–3.1M

Select item 1017409111.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 1016774112.

Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis

Shuang Li, Qinmao Ye, Jianxin Wei, Sarah J Taleb, Heather Wang, Yingze Zhang, Daniel J Kass, Jeffrey C Horowitz, Jing Zhao, Yutong Zhao

Transl Res. Author manuscript; available in PMC 2023 May 9.

Published in final edited form as: Transl Res. 2023 Mar; 253: 1–7. Published online 2022 Oct 17. doi: 10.1016/j.trsl.2022.10.002

PMCID:: PMC10167741

Abstract Article PDF–1.4M

Select item 1010317013.

Avidity-Based Method for the Efficient Generation of Monoubiquitinated Recombinant Proteins

Spencer L. Nelson, Yunan Li, Yue Chen, Lalit Deshmukh

J Am Chem Soc. 2023 Apr 12; 145(14): 7748–7752. Published online 2023 Apr 3. doi: 10.1021/jacs.3c01943

PMCID:: PMC10103170

Abstract Article PDF–6.4M

Select item 1008367514.

NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation

Hong Tang, Xiaomei Jiang, Yu Hua, Heyue Li, Chunlan Zhu, Xiaobai Hao, Minhui Yi, Linxia Li

Endocr Connect. 2023 Apr 1; 12(4): e220459. Prepublished online 2023 Jan 20. Published online 2023 Mar 17. doi: 10.1530/EC-22-0459

PMCID:: PMC10083675

Abstract Article PDF–2.2M

Select item 1007041815.

AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy

Xiaomei Zhang, Qiwei Jiang, Yaqing Su, Lang Bu, Zicheng Sun, Xueji Wu, Bing Gao, Lei Wang, Ying Lin, Wei Xie, Jianping Guo

Br J Cancer. 2023 Apr 12; 128(8): 1452–1465. Published online 2023 Feb 17. doi: 10.1038/s41416-022-02127-4

PMCID:: PMC10070418

Abstract Article PDF–2.8M

Select item 1006882016.

circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1

Shuang Chen, Ke Li, Jiawei Guo, Hai-Ning Chen, Yue Ming, Yang Jin, Fuyan Xu, Tingting Zhang, Yang Yang, Zixia Ye, Wenrong Liu, Hulin Ma, Jian Cheng, Jian-Kang Zhou, Zhang Li, Shu Shen, Lunzhi Dai, Zong-Guang Zhou, Heng Xu, Yong Peng

Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13): e2215132120. Published online 2023 Mar 24. doi: 10.1073/pnas.2215132120