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Select item 109058431.

Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma

Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun, Siwen Li

J Transl Med. 2024; 22: 216. Published online 2024 Feb 29. doi: 10.1186/s12967-023-04700-8

PMCID:: PMC10905843

Abstract Article PDF–8.7M

Select item 105688962.

MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib

Jinhui Guo, Jie Zhao, Qiuran Xu, Dongsheng Huang

BMC Cancer. 2023; 23: 967. Published online 2023 Oct 12. doi: 10.1186/s12885-023-11320-4

PMCID:: PMC10568896

Abstract Article PDF–2.4M

Select item 97725583.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 91052354.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 85664735.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81090857.

Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity

Kejin Huang, Dan Liu, Changlei Su

Aging (Albany NY) 2021 Apr 30; 13(8): 12058–12066. Published online 2021 Apr 25. doi: 10.18632/aging.202911

PMCID:: PMC8109085

Abstract Article PDF–1.6M

Select item 64618648.

LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Qingsong Hu, Chunlai Li, Shouyu Wang, Yajuan Li, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin, Liuqing Yang

Cell Res. 2019 Apr; 29(4): 286–304. Published online 2019 Jan 10. doi: 10.1038/s41422-018-0134-3

PMCID:: PMC6461864

Abstract Article PDF–11M

Select item 63911089.

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease

Yajuan Li, Qingsong Hu, Chunlai Li, Ke Liang, Yu Xiang, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, Chandrashekar R. Ambati, Nagireddy Putluri, David H. Hawke, Leng Han, Mien-Chie Hung, Farhad R. Danesh, Liuqing Yang, Chunru Lin

J Clin Invest. 2019 Mar 1; 129(3): 1129–1151. Published online 2019 Feb 11. doi: 10.1172/JCI121987

PMCID:: PMC6391108

Abstract Article PDF–65M

Select item 619426910.

Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase

Sayed Ala Moududee, Yiyang Jiang, Nshogoza Gilbert, Guodong Xie, Zheng Xu, Jihui Wu, Qingguo Gong, Yajun Tang, Yunyu Shi

Protein Sci. 2018 Sep; 27(9): 1661–1669. Published online 2018 Oct 18. doi: 10.1002/pro.3473

PMCID:: PMC6194269

Abstract Article PDF–503K

Select item 583915811.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 562891712.

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting

Pin Lu, Huanhuan Li, Ning Li, Ravi N. Singh, Colin E. Bishop, Xiangxian Chen, Baisong Lu

PLoS One. 2017; 12(10): e0185992. Published online 2017 Oct 5. doi: 10.1371/journal.pone.0185992

PMCID:: PMC5628917

Abstract Article PDF–14M

Select item 562505213.

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity

Lingna Yang, Chongyuan Wang, Fudong Li, Jiahai Zhang, Anam Nayab, Jihui Wu, Yunyu Shi, Qingguo Gong

J Biol Chem. 2017 Sep 29; 292(39): 16221–16234. Published online 2017 Aug 14. doi: 10.1074/jbc.M117.797746

PMCID:: PMC5625052

Abstract Article PDF–3.7M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 545599615.

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

Joseph Rosenbluh, Johnathan Mercer, Yashaswi Shrestha, Rachel Oliver, Pablo Tamayo, John G. Doench, Itay Tirosh, Federica Piccioni, Ella Hartenian, Heiko Horn, Lola Fagbami, David E. Root, Jacob Jaffe, Kasper Lage, Jesse S. Boehm, William C. Hahn

Cell Syst. Author manuscript; available in PMC 2017 Sep 28.

Published in final edited form as: Cell Syst. 2016 Sep 28; 3(3): 302–316.e4. doi: 10.1016/j.cels.2016.09.001

PMCID:: PMC5455996

Abstract Article PDF–3.1M

Select item 476457316.

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich

eLife. 2015; 4: e11466. Published online 2015 Dec 17. doi: 10.7554/eLife.11466

PMCID:: PMC4764573

Abstract Article PDF–5.7M

Select item 461760617.

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C

Florencia Cano, Radu Rapiteanu, G. Sebastiaan Winkler, Paul J. Lehner

Nat Commun. 2015; 6: 8670. Published online 2015 Oct 16. doi: 10.1038/ncomms9670

PMCID:: PMC4617606

Abstract Article PDF–1.6M

Select item 417058518.

Genome-Wide Analysis of Polymorphisms Associated with Cytokine Responses in Smallpox Vaccine Recipients

Richard B. Kennedy, Inna G. Ovsyannikova, V. Shane Pankratz, Iana H. Haralambieva, Robert A. Vierkant, Gregory A. Poland

Hum Genet. Author manuscript; available in PMC 2014 Sep 22.

Published in final edited form as: Hum Genet. 2012 Sep; 131(9): 1403–1421. Published online 2012 May 19. doi: 10.1007/s00439-012-1174-2

PMCID:: PMC4170585

Abstract Article PDF–594K

Select item 399266919.

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity

Kanako Kuniyoshi, Osamu Takeuchi, Surya Pandey, Takashi Satoh, Hidenori Iwasaki, Shizuo Akira, Taro Kawai

Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15): 5646–5651. Published online 2014 Mar 27. doi: 10.1073/pnas.1401674111

PMCID:: PMC3992669

Abstract Article PDF–1.1M

Select item 362758020.

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness

Bruno Pereira, Sofia Sousa, Rita Barros, Laura Carreto, Patrícia Oliveira, Carla Oliveira, Nicolas T. Chartier, Michelina Plateroti, Jean-Pierre Rouault, Jean-Noël Freund, Marc Billaud, Raquel Almeida

Nucleic Acids Res. 2013 Apr; 41(7): 3986–3999. Published online 2013 Feb 12. doi: 10.1093/nar/gkt087

PMCID:: PMC3627580

Abstract Article PDF–17M

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