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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110916662.

Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription

Bingdong Jiang, Binghua Yan, Hengjin Yang, He Geng, Peng Li

J Microbiol Biotechnol. 2024 Apr 28; 34(4): 920–929. Published online 2023 Nov 17. doi: 10.4014/jmb.2308.08026

PMCID:: PMC11091666

Abstract Article PDF–5.0M

Select item 100360923.

Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells

Mikio Shimada, Takumi Tokumiya, Tomoko Miyake, Kaima Tsukada, Norie Kanzaki, Hiromi Yanagihara, Junya Kobayashi, Yoshihisa Matsumoto

J Radiat Res. 2023 Mar; 64(2): 345–351. Published online 2023 Jan 11. doi: 10.1093/jrr/rrac099

PMCID:: PMC10036092

Abstract Article PDF–871K

Select item 97673424.

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

James P. Wells, Emily Yun-Chia Chang, Leticia Dinatto, Justin White, Stephanie Ryall, Peter C. Stirling

PLoS Genet. 2022 Dec; 18(12): e1010309. Published online 2022 Dec 8. doi: 10.1371/journal.pgen.1010309

PMCID:: PMC9767342

Abstract Article PDF–10M

Select item 97080865.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 96647296.

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Xue Wang, Han Cheng, Jing Zhao, Jiuming Li, Ying Chen, Kaisa Cui, Lu Tian, Jia Zhang, Chaoqun Li, Shengbai Sun, Yuyang Feng, Surui Yao, Zehua Bian, Shenglin Huang, Bojian Fei, Zhaohui Huang

Mol Cancer. 2022; 21: 210. Published online 2022 Nov 14. doi: 10.1186/s12943-022-01675-w

PMCID:: PMC9664729

Abstract Article PDF–20M

Select item 95826757.

RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p‐DNA‐PKcs

Xiaoqing Li, Shitao Zou, Liangsu Zhou, Aidi Gao, Jing Xu, Chao He, Jundong Zhou, Shuhua Wu, Yihong Chen

Cancer Med. 2022 Oct; 11(20): 3809–3819. Published online 2022 Apr 14. doi: 10.1002/cam4.4754

PMCID:: PMC9582675

Abstract Article PDF–2.4M

Select item 95403458.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 93719089.

LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms

Ruyuan Yu, Yameng Hu, Shuxia Zhang, Xincheng Li, Miaoling Tang, Meisongzhu Yang, Xingui Wu, Ziwen Li, Xinyi Liao, Yingru Xu, Man Li, Suwen Chen, Wanying Qian, Li-Yun Gong, Libing Song, Jun Li

Nucleic Acids Res. 2022 Aug 12; 50(14): 8060–8079. Published online 2022 Jul 18. doi: 10.1093/nar/gkac611

PMCID:: PMC9371908

Abstract Article PDF–13M

Select item 927928510.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 916199211.

UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization

Xi Zeng, Wen Zheng, Yuting Sheng, Hongwei Ma

Bioengineered. 2022; 13(4): 8000–8012. Published online 2022 Mar 22. doi: 10.1080/21655979.2022.2048991

PMCID:: PMC9161992

Abstract Article PDF–3.7M

Select item 911973612.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 903454913.

Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

Mingrui Du, Jintao Gu, Chenlin Liu, Nannan Liu, Zhe Yu, Chengpei Zhou, Wei Heng, Zhengcong Cao, Feilong Wei, Kailong Zhu, Yingwen Wang, Wei Zhang, Xiaochang Xue, Yong Zhang, Jixian Qian

J Exp Clin Cancer Res. 2022; 41: 154. Published online 2022 Apr 23. doi: 10.1186/s13046-022-02344-y

PMCID:: PMC9034549

Abstract Article PDF–5.6M

Select item 895832514.

A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade

Gabriel Fenteany, Gaurav Sharma, Paras Gaur, Attila Borics, Edit Wéber, Ernő Kiss, Lajos Haracska

iScience. 2022 Apr 15; 25(4): 104053. Published online 2022 Mar 10. doi: 10.1016/j.isci.2022.104053

PMCID:: PMC8958325

Abstract Article PDF–3.2M

Select item 882889515.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 881417916.

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis

Yunshang Chen, Xiaohua Jie, Biyuan Xing, Zilong Wu, Xijie Yang, Xinrui Rao, Yingzhuo Xu, Dong Zhou, Xiaorong Dong, Tao Zhang, Kunyu Yang, Zhenyu Li, Gang Wu

Cell Death Dis. 2022 Feb; 13(2): 110. Published online 2022 Feb 3. doi: 10.1038/s41419-022-04567-5

PMCID:: PMC8814179

Abstract Article PDF–6.0M

Select item 817992917.

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase

Alexandra Daks, Alexey Petukhov, Olga Fedorova, Oleg Shuvalov, Alena Kizenko, Elizaveta Tananykina, Elena Vasileva, Oleg Semenov, Andrew Bottrill, Nickolai Barlev

Cell Death Dis. 2021 Jun; 12(6): 581. Published online 2021 Jun 5. doi: 10.1038/s41419-021-03871-w

PMCID:: PMC8179929

Abstract Article PDF–2.6M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810809319.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 806935520.

Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress

Domenico Maiorano, Jana El Etri, Camille Franchet, Jean-Sébastien Hoffmann

Int J Mol Sci. 2021 Apr; 22(8): 3924. Published online 2021 Apr 10. doi: 10.3390/ijms22083924

PMCID:: PMC8069355

Abstract Article PDF–2.9M

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