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Select item 105440061.

Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer

Yonghong Chen, Catherine R. Dufour, Lingwei Han, Ting Li, Hui Xia, Vincent Giguère

Mol Cancer Res. 2023 Oct 2; 21(10): 1050–1063. Published online 2023 Jul 6. doi: 10.1158/1541-7786.MCR-23-0086

PMCID:: PMC10544006

Abstract Article PDF–5.7M

Select item 98126332.

Germline Variants in DNA Damage Repair Genes and HOXB13 Among Black Patients With Early-Onset Prostate Cancer

Matthew R. Trendowski, Christopher Sample, Tara Baird, Azita Sadeghpour, David Moon, Julie J. Ruterbusch, Jennifer L. Beebe-Dimmer, Kathleen A. Cooney

JCO Precis Oncol. 2022; 6: e2200460. Published online 2022 Nov 29. doi: 10.1200/PO.22.00460

PMCID:: PMC9812633

Abstract Article PDF–247K

Select item 94817283.

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

Duy T. Nguyen, Wei Yang, Arun Renganathan, Cody Weimholt, Duminduni H. Angappulige, Thanh Nguyen, Robert W. Sprung, Gerald L. Andriole, Eric H. Kim, Nupam P. Mahajan, Kiran Mahajan

Clin Cancer Res. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: Clin Cancer Res. 2022 Jul 18 : CCR-21-3603. Published online 2022 Jul 18. doi: 10.1158/1078-0432.CCR-21-3603

PMCID:: PMC9481728

Abstract Article PDF–3.5M

Select item 93576584.

Comprehensive network analysis of dysregulated genes revealed MNX1‐AS1/hsa‐miR‐4697‐3p/HOXB13 axis in ovarian cancer chemotherapy response

Anqi Wu, Jiaqi Liu, Xiaojun Zhang, Chenxi Niu, Guang Shu, Gang Yin

Cancer Sci. 2022 Aug; 113(8): 2627–2641. Published online 2022 Jun 24. doi: 10.1111/cas.15447

PMCID:: PMC9357658

Abstract Article PDF–17M

Select item 93464715.

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation

Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung

EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468

PMCID:: PMC9346471

Abstract Article PDF–5.2M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91174667.

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

Xiaodong Lu, Ka-wing Fong, Galina Gritsina, Fang Wang, Sylvan C. Baca, Lourdes T. Brea, Jacob E. Berchuck, Sandor Spisak, Jenny Ross, Colm Morrissey, Eva Corey, Navdeep S. Chandel, William J. Catalona, Ximing Yang, Matthew L. Freedman, Jonathan C. Zhao, Jindan Yu

Nat Genet. Author manuscript; available in PMC 2022 Oct 25.

Published in final edited form as: Nat Genet. 2022 May; 54(5): 670–683. Published online 2022 Apr 25. doi: 10.1038/s41588-022-01045-8

PMCID:: PMC9117466

Abstract Article PDF–7.2M

Select item 90855868.

miR-20a-5p通过下调HOXB13基因表达抑制肺癌细胞系A549增殖

刘海军, 王杰, 申珈馨, 吴旭, 李玉磊

Nan Fang Yi Ke Da Xue Xue Bao. 2022 Apr 20; 42(4): 568–574. Chinese. doi: 10.12122/j.issn.1673-4254.2022.04.13

PMCID:: PMC9085586

Abstract Article PDF–2.3M

Select item 90185209.

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry

Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja I. Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J.M. Hennis, Alexander Lubwama, Ian M. Thompson, Jr, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T.H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W.K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David V. Conti, Christopher A. Haiman

Eur Urol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Eur Urol. 2022 May; 81(5): 458–462. Published online 2022 Jan 12. doi: 10.1016/j.eururo.2021.12.023

PMCID:: PMC9018520

Abstract Article PDF–275K

Select item 888855910.

The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients

Rong Na, Jun Wei, Chris J. Sample, Marta Gielzak, Sodam Choi, Kathleen A. Cooney, Daniel Rabizadeh, Patrick C. Walsh, Lilly S. Zheng, Jianfeng Xu, William B. Isaacs

Br J Cancer. 2022 Mar 23; 126(5): 791–796. Published online 2021 Nov 19. doi: 10.1038/s41416-021-01622-4

PMCID:: PMC8888559

Abstract Article PDF–376K

Select item 859735911.

HOXB13 and TFF3 can contribute to the prognostic stratification of prostate adenocarcinoma

Andrei Daniel Timofte, Simona Eliza Giuşcă, Ludmila Lozneanu, Mariana Bianca Manole, Iulian Prutianu, Bogdan Gafton, Andreea Rusu, Irina-Draga Căruntu

Rom J Morphol Embryol. 2021 Jan-Mar; 62(1): 41–52. Published online 2021 Jul 26. doi: 10.47162/RJME.62.1.04

PMCID:: PMC8597359

Abstract Article PDF–2.7M

Select item 838303412.

HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway

Hui Geng, Guangli Liu, Jiandong Hu, Jianchao Li, Dong Wang, Shenshan Zou, Xintao Xu

Mol Med Rep. 2021 Oct; 24(4): 722. Published online 2021 Aug 11. doi: 10.3892/mmr.2021.12361

PMCID:: PMC8383034

Abstract Article PDF–15M

Select item 816711913.

Prostate cancer risk variants of the HOXB genetic locus

William D. Dupont, Joan P. Breyer, Spenser H. Johnson, W. Dale Plummer, Jeffrey R. Smith

Sci Rep. 2021; 11: 11385. Published online 2021 May 31. doi: 10.1038/s41598-021-89399-7

PMCID:: PMC8167119

Abstract Article PDF–1.7M

Select item 800904814.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 797926415.

Upregulated long non-coding RNA LincIN promotes tumor progression via the regulation of nuclear factor 90/microRNA-7/HOXB13 in esophageal squamous cell carcinoma

Zhibo Tan, Peitao Zhou, Zhenru Zhu, Ying Wang, Zeqin Guo, Mengying Shen, Yazhi Xiao, Weixi Shen, Dehua Wu

Int J Mol Med. 2021 May; 47(5): 78. Published online 2021 Mar 10. doi: 10.3892/ijmm.2021.4911

PMCID:: PMC7979264

Abstract Article PDF–1.6M

Select item 791241216.

Long Noncoding RNA HOXA11-AS and Transcription Factor HOXB13 Modulate the Expression of Bone Metastasis-Related Genes in Prostate Cancer

Aya Misawa, Yukihiro Kondo, Hiroyuki Takei, Toshihiro Takizawa

Genes (Basel) 2021 Feb; 12(2): 182. Published online 2021 Jan 27. doi: 10.3390/genes12020182

PMCID:: PMC7912412

Abstract Article PDF–5.1M

Select item 785458217.

Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression

Siyuan Cheng, Shu Yang, Yingli Shi, Runhua Shi, Yunshin Yeh, Xiuping Yu

Sci Rep. 2021; 11: 2778. Published online 2021 Feb 2. doi: 10.1038/s41598-021-82472-1

PMCID:: PMC7854582

Abstract Article PDF–10M

Select item 773620518.

Somatic HOXB13 Expression Correlates with Metastatic Progression in Men with Localized Prostate Cancer Following Radical Prostatectomy

Adam B. Weiner, Farzana A. Faisal, Elai Davicioni, R. Jeffrey Karnes, Donald J. Vander Griend, Tamara L. Lotan, Edward M. Schaeffer

Eur Urol Oncol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Eur Urol Oncol. 2021 Dec; 4(6): 955–962. Published online 2020 Jun 12. doi: 10.1016/j.euo.2020.05.001

PMCID:: PMC7736205

Abstract Article PDF–1.2M

Select item 771053119.

The HOXB13 p.Gly84Glu variant observed in an extended five generation high-risk prostate cancer pedigree supports risk association for multiple cancer sites

Lisa A Cannon-Albright, Jeff Stevens, Craig C Teerlink, Neeraj Agarwal

Cancer Epidemiol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Cancer Epidemiol. 2020 Dec; 69: 101834. Published online 2020 Oct 21. doi: 10.1016/j.canep.2020.101834

PMCID:: PMC7710531

Abstract Article PDF–127K

Select item 759191120.

Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank

Jun Wei, Zhuqing Shi, Rong Na, Chi-Hsiung Wang, W. Kyle Resurreccion, S. Lilly Zheng, Peter J. Hulick, Kathleen A. Cooney, Brian T. Helfand, William B. Isaacs, Jianfeng Xu

Br J Cancer. 2020 Oct 27; 123(9): 1356–1359. Published online 2020 Aug 24. doi: 10.1038/s41416-020-01036-8

PMCID:: PMC7591911

Abstract Article PDF–257K

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