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Select item 110769891.

Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

CNS Neurosci Ther. 2024 May; 30(5): e14742. Published online 2024 May 7. doi: 10.1111/cns.14742

PMCID:: PMC11076989

Abstract Article PDF–20M

Select item 83473952.

Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A₃ Receptor Subtype

Elisabetta Coppi, Federica Cherchi, Elena Lucarini, Carla Ghelardini, Felicita Pedata, Kenneth A. Jacobson, Lorenzo Di Cesare Mannelli, Anna Maria Pugliese, Daniela Salvemini

Int J Mol Sci. 2021 Aug; 22(15): 7952. Published online 2021 Jul 26. doi: 10.3390/ijms22157952

PMCID:: PMC8347395

Abstract Article PDF–1.4M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80271704.

Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells

Jiacheng Bi, Chaoyue Zheng, Xiaohu Zheng

Cell Mol Immunol. 2021 Feb; 18(2): 496–497. Published online 2021 Jan 8. doi: 10.1038/s41423-020-00632-1

PMCID:: PMC8027170

Article PDF–793K

Select item 75827545.

Activation of Adenosine A₃ Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure

Joana Ferreira-Silva, Inês D. Aires, Raquel Boia, António Francisco Ambrósio, Ana Raquel Santiago

Int J Mol Sci. 2020 Oct; 21(19): 7218. Published online 2020 Sep 30. doi: 10.3390/ijms21197218

PMCID:: PMC7582754

Abstract Article PDF–4.4M

Select item 74041376.

Adenosine A_2A and A₃ Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling

Alejandro Lillo, Eva Martínez-Pinilla, Irene Reyes-Resina, Gemma Navarro, Rafael Franco

Int J Mol Sci. 2020 Jul; 21(14): 5070. Published online 2020 Jul 17. doi: 10.3390/ijms21145070

PMCID:: PMC7404137

Abstract Article PDF–1.5M

Select item 70011497.

A₃ Adenosine Receptor Activation Mechanisms: Molecular Dynamics Analysis of Inactive, Active, and Fully Active States

Antonella Ciancetta, Priscila Rubio, David I. Lieberman, Kenneth A. Jacobson

J Comput Aided Mol Des. Author manuscript; available in PMC 2020 Nov 22.

Published in final edited form as: J Comput Aided Mol Des. 2019 Nov; 33(11): 983–996. Published online 2019 Nov 22. doi: 10.1007/s10822-019-00246-4

PMCID:: PMC7001149

Abstract Article PDF–1.7M

Select item 68322578.

Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy

Aaron Tan, Maria V. Babak, Gopalakrishnan Venkatesan, Clarissa Lim, Karl-Norbert Klotz, Deron Raymond Herr, Siew Lee Cheong, Stephanie Federico, Giampiero Spalluto, Wei-Yi Ong, Yu Zong Chen, Jason Siau Ee Loo, Giorgia Pastorin

Molecules. 2019 Oct; 24(20): 3661. Published online 2019 Oct 11. doi: 10.3390/molecules24203661

PMCID:: PMC6832257

Abstract Article PDF–2.8M

Select item 66220389.

CXCL16 Orchestrates Adenosine A₃ Receptor and MCP-1/CCL2 Activity to Protect Neurons from Excitotoxic Cell Death in the CNS

Maria Rosito, Cristina Deflorio, Cristina Limatola, Flavia Trettel

J Neurosci. 2012 Feb 29; 32(9): 3154–3163. doi: 10.1523/JNEUROSCI.4046-11.2012

PMCID:: PMC6622038

Abstract Article PDF–1.7M

Select item 600089010.

The Polymorphism in ADORA3 Decreases Transcriptional Activity and Influences the Chronic Heart Failure Risk in the Chinese

Hai-Rong He, Yuan-Jie Li, Gong-Hao He, Hua Qiang, Ya-Jing Zhai, Mao Ma, Ya-Jun Wang, Yan Wang, Xiao-Wei Zheng, Ya-Lin Dong, Jun Lyu

Biomed Res Int. 2018; 2018: 4969385. Published online 2018 May 31. doi: 10.1155/2018/4969385

PMCID:: PMC6000890

Abstract Article PDF–921K

Select item 597949611.

The Adenosine A₃ Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia

René Rocha, Ángelo Torres, Karina Ojeda, Daniel Uribe, Dellis Rocha, José Erices, Ignacio Niechi, Pamela Ehrenfeld, Rody San Martín, Claudia Quezada

Int J Mol Sci. 2018 Apr; 19(4): 1228. Published online 2018 Apr 18. doi: 10.3390/ijms19041228

PMCID:: PMC5979496

Abstract Article PDF–9.6M

Select item 560255712.

Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A₃ Adenosine Receptor

Zhan-Guo Gao, Aishe Chen, Dov Barak, Soo-Kyung Kim, Christa E. Müller, Kenneth A. Jacobson

J Biol Chem. Author manuscript; available in PMC 2017 Sep 18.

Published in final edited form as: J Biol Chem. 2002 May 24; 277(21): 19056–19063. Published online 2002 Mar 12. doi: 10.1074/jbc.M110960200

PMCID:: PMC5602557

Abstract Article PDF–1.0M

Select item 555089313.

Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A₁ or A₃ receptor

CHARLES DOUGHERTY, JULIE BARUCHA, PETER R. SCHOFIELD, KENNETH A. JACOBSON, BRUCE T. LIANG

FASEB J. Author manuscript; available in PMC 2017 Aug 10.

Published in final edited form as: FASEB J. 1998 Dec; 12(15): 1785–1792. doi: 10.1096/fasebj.12.15.1785

PMCID:: PMC5550893

Abstract Article PDF–788K

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 535219115.

MicroRNA-206 is involved in the pathogenesis of ulcerative colitis via regulation of adenosine A3 receptor

Weiyun Wu, Yanting He, Xiao Feng, Shicai Ye, Hao Wang, Wenkai Tan, Caiyuan Yu, Juxiang Hu, Rong Zheng, Yu Zhou

Oncotarget. 2017 Jan 3; 8(1): 705–721. Published online 2016 Nov 23. doi: 10.18632/oncotarget.13525

PMCID:: PMC5352191

Abstract Article PDF–10M

Select item 513365916.

Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

Swathi V. Iyer, Atul Ranjan, Harold K. Elias, Alejandro Parrales, Hiromi Sasaki, Badal C. Roy, Shahid Umar, Ossama W. Tawfik, Tomoo Iwakuma

Nat Commun. 2016; 7: 13561. Published online 2016 Nov 25. doi: 10.1038/ncomms13561

PMCID:: PMC5133659

Abstract Article PDF–2.3M

Select item 480664317.

A₃ Adenosine Receptors in Human Astrocytoma Cells: Agonist-Mediated Desensitization, Internalization, and Down-Regulation

M. L. TRINCAVELLI, D. TUSCANO, M. MARRONI, A. FALLENI, V. GREMIGNI, S. CERUTI, M. P. ABBRACCHIO, K. A. JACOBSON, F. CATTABENI, C. MARTINI

Mol Pharmacol. Author manuscript; available in PMC 2016 Mar 24.

Published in final edited form as: Mol Pharmacol. 2002 Dec; 62(6): 1373–1384. doi: 10.1124/mol.62.6.1373

PMCID:: PMC4806643

Abstract Article PDF–1.5M

Select item 471567718.

Distinct transcriptome profiles differentiate NSAID-dependent from NSAID-independent food anaphylaxis

Rosa Muñoz-Cano, Mariona Pascal, Joan Bartra, Cesar Picado, Antonio Valero, Do-Kyun Kim, Stephen Brooks, Michael Ombrello, Dean D. Metcalfe, Juan Rivera, Ana Olivera

J Allergy Clin Immunol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: J Allergy Clin Immunol. 2016 Jan; 137(1): 137–146. Published online 2015 Jul 17. doi: 10.1016/j.jaci.2015.05.042

PMCID:: PMC4715677

Abstract Article PDF–1.6M

Select item 461721119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 436754120.

Identification of Essential Residues Involved in the Allosteric Modulation of the Human A₃ Adenosine Receptor

ZHAN-GUO GAO, SOO-KYUNG KIM, ARIEL S. GROSS, AISHE CHEN, JOSHUA B. BLAUSTEIN, KENNETH A. JACOBSON

Mol Pharmacol. Author manuscript; available in PMC 2015 Mar 20.

Published in final edited form as: Mol Pharmacol. 2003 May; 63(5): 1021–1031. doi: 10.1124/mol.63.5.1021

PMCID:: PMC4367541

Abstract Article PDF–941K

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