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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 97340422.

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Antoine Cherix, Carole Poitry-Yamate, Bernard Lanz, Olivia Zanoletti, Jocelyn Grosse, Carmen Sandi, Rolf Gruetter, Jean-René Cardinaux

Mol Psychiatry. 2022; 27(11): 4485–4501. Published online 2022 Oct 12. doi: 10.1038/s41380-022-01791-5

PMCID:: PMC9734042

Abstract Article PDF–5.0M

Select item 90670833.

Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity

Min Gu, Zhen Wang, Feifei Feng, Yongjian Yang, Xiongshan Sun, Dachun Yang

J Cardiovasc Pharmacol. 2022 May; 79(5): 739–748. Published online 2022 Mar 11. doi: 10.1097/FJC.0000000000001243

PMCID:: PMC9067083

Abstract Article PDF–950K

Select item 87543334.

Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice

Jin Tanaka, Fuka Ishikawa, Tomoki Jinno, Motoki Miyakita, Haruka Miyamori, Tsutomu Sasaki, Takumi Yokokawa, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumura

PLoS One. 2022; 17(1): e0262577. Published online 2022 Jan 12. doi: 10.1371/journal.pone.0262577

PMCID:: PMC8754333

Abstract Article PDF–4.0M

Select item 86825205.

Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet

Shigenobu Matsumura, Fuka Ishikawa, Tsutomu Sasaki, Mike Krogh Terkelsen, Kim Ravnskjaer, Tomoki Jinno, Jin Tanaka, Tsuyoshi Goto, Kazuo Inoue

Endocrinology. 2021 Sep; 162(9): bqab076. Published online 2021 Apr 12. doi: 10.1210/endocr/bqab076

PMCID:: PMC8682520

Abstract Article

Select item 83680256.

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning

Mol Metab. 2021 Nov; 53: 101309. Published online 2021 Jul 23. doi: 10.1016/j.molmet.2021.101309

PMCID:: PMC8368025

Abstract Article PDF–3.3M

Select item 83276497.

MTORC1 inhibition drives crinophagic degradation of glucagon

Sangam Rajak, Sherwin Xie, Archana Tewari, Sana Raza, Yajun Wu, Boon-Huat Bay, Paul M. Yen, Rohit A. Sinha

Mol Metab. 2021 Nov; 53: 101286. Published online 2021 Jul 2. doi: 10.1016/j.molmet.2021.101286

PMCID:: PMC8327649

Abstract Article PDF–2.0M

Select item 82385108.

Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

Xin Zhou, Jennifer W Li, Zirong Chen, Wei Ni, Xuehui Li, Rongqiang Yang, Huangxuan Shen, Jian Liu, Francesco J DeMayo, Jianrong Lu, Frederic J Kaye, Lizi Wu

eLife. 2021; 10: e66095. Published online 2021 Jun 18. doi: 10.7554/eLife.66095

PMCID:: PMC8238510

Abstract Article PDF–6.1M

Select item 80754109.

Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose

Yimeng Hu, Jian Lv, Yu Fang, Qiang Luo, Yuan He, Lili Li, Mingxia Fan, Zhihua Wang

Front Cell Dev Biol. 2021; 9: 602529. Published online 2021 Apr 12. doi: 10.3389/fcell.2021.602529

PMCID:: PMC8075410

Abstract Article PDF–4.6M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 791436511.

MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways

Pengbo Lou, Xueyun Bi, Yuhua Tian, Guilin Li, Qianqian Kang, Cong Lv, Yongli Song, Jiuzhi Xu, Xiaole Sheng, Xu Yang, Ruiqi Liu, Qingyong Meng, Fazheng Ren, Maksim V. Plikus, Bin Liang, Bing Zhang, Huiyuan Guo, Zhengquan Yu

Theranostics. 2021; 11(8): 3607–3623. Published online 2021 Jan 25. doi: 10.7150/thno.50900

PMCID:: PMC7914365

Abstract Article PDF–3.3M

Select item 687731312.

mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation

Kaushal Asrani, Sanjana Murali, Brandon Lam, Chan-Hyun Na, Pornima Phatak, Akshay Sood, Harsimar Kaur, Zoya Khan, Michaël Noë, Ravi K. Anchoori, C. Conover Talbot, Jr., Barbara Smith, Michael Skaro, Tamara L. Lotan

J Clin Invest. 2019 Dec 2; 129(12): 5584–5599. Published online 2019 Nov 11. doi: 10.1172/JCI128287

PMCID:: PMC6877313

Abstract Article PDF–16M

Select item 682337713.

Salt-inducible kinase 1 regulates bone anabolism via the CRTC1–CREB–Id1 axis

Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Bongjun Kim, Haemin Kim, Zang Hee Lee, Seung-Hoi Koo, Hong-Hee Kim

Cell Death Dis. 2019 Nov; 10(11): 826. Published online 2019 Oct 31. doi: 10.1038/s41419-019-1915-4

PMCID:: PMC6823377

Abstract Article PDF–8.4M

Select item 663242414.

β-Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1

Judit España, Jorge Valero, Alfredo J. Miñano-Molina, Roser Masgrau, Elsa Martín, Cristina Guardia-Laguarta, Alberto Lleó, Lydia Giménez-Llort, José Rodríguez-Alvarez, Carlos A. Saura

J Neurosci. 2010 Jul 14; 30(28): 9402–9410. doi: 10.1523/JNEUROSCI.2154-10.2010