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Select item 112476641.

Post‐GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3

Daniel J. Panyard, Lianne M. Reus, Muhammad Ali, Jihua Liu, Yuetiva K. Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J. Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M. Carlsson, Sterling C. Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M. Tijms, Corinne D. Engelman, Michael P. Snyder

Alzheimers Dement. 2024 Jul; 20(7): 5044–5053. Published online 2024 May 29. doi: 10.1002/alz.13848

PMCID:: PMC11247664

Abstract Article PDF–1.1M

Select item 104280752.

Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma

Fu-Ju Lei, Jung-Ying Chiang, Huan-Jui Chang, Der-Cherng Chen, Hwai-Lee Wang, Hsi-An Yang, Kai-Yu Wei, Yen‐Chih Huang, Chi-Chung Wang, Sung-Tai Wei, Chia-Hung Hsieh

Redox Biol. 2023 Sep; 65: 102831. Published online 2023 Aug 5. doi: 10.1016/j.redox.2023.102831

PMCID:: PMC10428075

Abstract Article PDF–16M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102317534.

Polyalanine polymorphism in the signal peptide of Glutathione peroxidase 1 (GPX1) gene & its association with osteoporosis

Soni Ghumnani Ahuja, Arjun Shahu, Subrata Rath, Neeraj Adkar, Yogesh Shouche, Saroj Ghaskadbi, Richa Ashma

Indian J Med Res. 2022 Oct-Nov; 156(4-5): 640–647. Published online 2023 Mar 11. doi: 10.4103/ijmr.IJMR_208_20

PMCID:: PMC10231753

Abstract Article PDF–2.1M

Select item 98609625.

Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness

Predrag Nikic, Dejan Dragicevic, Djurdja Jerotic, Slaviša Savic, Tatjana Djukic, Branko Stankovic, Luka Kovacevic, Tatjana Simic, Marija Matic

Medicina (Kaunas) 2023 Jan; 59(1): 131. Published online 2023 Jan 9. doi: 10.3390/medicina59010131

PMCID:: PMC9860962

Abstract Article PDF–356K

Select item 98519736.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 98273807.

Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides

Maria Schwarz, Alina Löser, Qing Cheng, Mareike Wichmann-Costaganna, Patrick Schädel, Oliver Werz, Elias SJ. Arnér, Anna P. Kipp

Redox Biol. 2023 Feb; 59: 102593. Published online 2023 Jan 2. doi: 10.1016/j.redox.2022.102593

PMCID:: PMC9827380

Abstract Article PDF–3.0M

Select item 96291218.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 96119829.

The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer

Milica Djokic, Tanja Radic, Veljko Santric, Dejan Dragicevic, Sonja Suvakov, Smiljana Mihailovic, Vesna Stankovic, Milica Cekerevac, Tatjana Simic, Marina Nikitovic, Vesna Coric

Medicina (Kaunas) 2022 Oct; 58(10): 1414. Published online 2022 Oct 9. doi: 10.3390/medicina58101414

PMCID:: PMC9611982

Abstract Article PDF–751K

Select item 940870210.

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters

Benoît Chevalier, Nesrine Baatallah, Matthieu Najm, Solène Castanier, Vincent Jung, Iwona Pranke, Anita Golec, Véronique Stoven, Stefano Marullo, Fabrice Antigny, Ida Chiara Guerrera, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter

Int J Mol Sci. 2022 Aug; 23(16): 8937. Published online 2022 Aug 11. doi: 10.3390/ijms23168937

PMCID:: PMC9408702

Abstract Article PDF–3.5M

Select item 938043211.

Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway

Bo Lu, Jianhua Li, MingTai Gui, Lei Yao, Mingsong Fan, Xunjie Zhou, Deyu Fu

Pharm Biol. 2022; 60(1): 1458–1468. Published online 2022 Aug 14. doi: 10.1080/13880209.2022.2096644

PMCID:: PMC9380432

Abstract Article PDF–3.0M

Select item 930417912.

The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase‐1 (GPx1) gene and autism spectrum disorder

Federica Carducci, Chiara Ardiccioni, Rosamaria Fiorini, Arianna Vignini, Alice Di Paolo, Sonila Alia, Marco Barucca, Maria Assunta Biscotti

Autism Res. 2022 Feb; 15(2): 215–221. Published online 2022 Jan 8. doi: 10.1002/aur.2655

PMCID:: PMC9304179

Abstract Article PDF–846K

Select item 897953313.

SOD2 rs4880 and GPX1 rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort

Djurdja Jerotic, Jovan Ranin, Zoran Bukumiric, Tatjana Djukic, Vesna Coric, Ana Savic-Radojevic, Nevena Todorovic, Milika Asanin, Marko Ercegovac, Ivana Milosevic, Marija Pljesa-Ercegovac, Goran Stevanovic, Marija Matic, Tatjana Simic

Redox Rep. 2022; 27(1): 85–91. Published online 2022 Mar 31. doi: 10.1080/13510002.2022.2057707

PMCID:: PMC8979533

Abstract Article PDF–1.6M

Select item 887191814.

An Assessment of GPX1 (rs1050450), DIO2 (rs225014) and SEPP1 (rs7579) Gene Polymorphisms in Women with Endometrial Cancer

Magdalena Janowska, Natalia Potocka, Sylwia Paszek, Marzena Skrzypa, Kamila Żulewicz, Marta Kluz, Sławomir Januszek, Piotr Baszuk, Jacek Gronwald, Jan Lubiński, Izabela Zawlik, Tomasz Kluz

Genes (Basel) 2022 Feb; 13(2): 188. Published online 2022 Jan 21. doi: 10.3390/genes13020188

PMCID:: PMC8871918

Abstract Article PDF–267K

Select item 884216515.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 820315416.

Evaluation of saliva glutathione, glutathione peroxidase, and malondialdehyde levels in head-neck radiotherapy patients

Gözde DERİNDAĞ, Hayati Murat AKGÜL, Ahmet KIZILTUNÇ, Halil İbrahim ÖZKAN, Hilal KIZILTUNÇ ÖZMEN, Nilgün AKGÜL

Turk J Med Sci. 2021; 51(2): 644–649. Published online 2021 Apr 30. doi: 10.3906/sag-2006-84

PMCID:: PMC8203154

Abstract Article PDF–96K

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794896418.

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1

Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D.F. Licchesi

J Biol Chem. 2021 Jan-Jun; 296: 100246. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015162