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Select item 112065341.

The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment

Szilvia Juhász, Rebecca Smith, Tamás Schauer, Dóra Spekhardt, Hasan Mamar, Siham Zentout, Catherine Chapuis, Sébastien Huet, Gyula Timinszky

Sci Adv. 2020 Dec; 6(51): eabb8626. Published online 2020 Dec 18. doi: 10.1126/sciadv.abb8626

PMCID:: PMC11206534

Abstract Article PDF–2.9M

Select item 111940942.

The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Joanne Saldanha, Julie Rageul, Jinal A Patel, Amy L Phi, Natalie Lo, Jennifer J Park, Hyungjin Kim

Nucleic Acids Res. 2024 Jun 24; 52(11): 6424–6440. Published online 2024 May 27. doi: 10.1093/nar/gkae445

PMCID:: PMC11194094

Abstract Article PDF–2.9M

Select item 111618713.

Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition

Caroline Fidalgo Ribeiro, Silvia Rodrigues, Debora Campanella Bastos, Giuseppe Nicolò Fanelli, Hubert Pakula, Marco Foiani, Giorgia Zadra, Massimo Loda

Sci Signal. Author manuscript; available in PMC 2024 Jun 8.

Published in final edited form as: Sci Signal. 2024 Apr 9; 17(831): eadh1922. Published online 2024 Apr 9. doi: 10.1126/scisignal.adh1922

PMCID:: PMC11161871

Abstract Article PDF–2.6M

Select item 111598404.

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer

Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park

Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x

PMCID:: PMC11159840

Abstract Article PDF–209K

Select item 110669855.

PARP1 UFMylation ensures the stability of stalled replication forks

Yamin Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2322520121. Published online 2024 Apr 24. doi: 10.1073/pnas.2322520121

PMCID:: PMC11066985

Abstract Article PDF–1.5M

Select item 109608596.

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor

Nat Commun. 2024; 15: 2599. Published online 2024 Mar 23. doi: 10.1038/s41467-024-46824-5

PMCID:: PMC10960859

Abstract Article PDF–2.3M

Select item 108909327.

TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma

Longpo Geng, Mingming Zhu, Dongjun Luo, Huihui Chen, Binghua Li, Yuanxiang Lao, Hongda An, Yue Wu, Yunzheng Li, Anliang Xia, Yi Shi, Zhuting Tong, Shanshan Lu, Dengqiu Xu, Xu Wang, Wenjun Zhang, Beicheng Sun, Zhu Xu

Oncogene. 2024; 43(9): 682–692. Published online 2024 Jan 12. doi: 10.1038/s41388-023-02935-9

PMCID:: PMC10890932

Abstract Article PDF–3.8M

Select item 108867658.

A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts

Svetlana N. Khodyreva, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alina S. Kochetkova, Alexandra A. Yamskikh, Ekaterina A. Maltseva, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Olga I. Lavrik

Cells. 2024 Feb; 13(4): 302. Published online 2024 Feb 6. doi: 10.3390/cells13040302

PMCID:: PMC10886765

Abstract Article PDF–2.4M

Select item 108845369.

Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression

Lulu Han, Yuxin Chen, Nan Huang, Xiaowan Zhou, Yanfang Lv, Huizhong Li, Dafei Chai, Junnian Zheng, Gang Wang

Cancer Biol Med. 2024 Feb 15; 21(2): 175–192. Published online 2024 Jan 2. doi: 10.20892/j.issn.2095-3941.2023.0248

PMCID:: PMC10884536

Abstract Article PDF–2.8M

Select item 1088399910.

Value of the NF-κB signalling pathway and the DNA repair gene PARP1 in predicting distant metastasis after breast cancer surgery

Kaiyong Pan, Xiabin Li, Junfang He, Yuxi Lei, Yongxin Yang, Deyong Jiang, Yan Tang

Sci Rep. 2024; 14: 4402. Published online 2024 Feb 22. doi: 10.1038/s41598-023-49156-4

PMCID:: PMC10883999

Abstract Article PDF–2.2M

Select item 1085895511.

circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation

Yan Wang, Yihao Wang, Chunjie Wu, Yunfei Ji, Pingfu Hou, Xueqing Wu, Zhongwei Li, Minle Li, Sufang Chu, Qianqian Ning, Bo Xu, Junnian Zheng, Jin Bai

Cell Death Discov. 2024; 10: 72. Published online 2024 Feb 10. doi: 10.1038/s41420-024-01836-4

PMCID:: PMC10858955

Abstract Article PDF–6.9M

Select item 1076495812.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1063905013.

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance

Julia O’Sullivan, Charu Kothari, Marie-Christine Caron, Jean-Philippe Gagné, Zhigang Jin, Louis Nonfoux, Adèle Beneyton, Yan Coulombe, Mélissa Thomas, Nurgul Atalay, X Wei Meng, Larissa Milano, Dominique Jean, François-Michel Boisvert, Scott H Kaufmann, Michael J Hendzel, Jean-Yves Masson, Guy G Poirier

Nucleic Acids Res. 2023 Nov 10; 51(20): 11056–11079. Published online 2023 Oct 12. doi: 10.1093/nar/gkad791

PMCID:: PMC10639050

Abstract Article PDF–6.7M

Select item 1062908514.

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA

Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan, Wan-Wan Lin

J Biomed Sci. 2023; 30: 91. Published online 2023 Nov 7. doi: 10.1186/s12929-023-00978-4

PMCID:: PMC10629085

Abstract Article PDF–2.9M

Select item 1061767315.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 1056785316.

USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation

Deng Yong Zhang, Yan Zhu, Qiong Wu, Shuoshuo Ma, Yang Ma, Zheng chao Shen, Zhonglin Wang, Wanliang Sun, Yong Chun Zhou, Dongdong Wang, Shuo Zhou, Zhong Liu, Lawrence N. Kwong, Zheng Lu

Cell Death Dis. 2023 Oct; 14(10): 669. Published online 2023 Oct 11. doi: 10.1038/s41419-023-06172-6

PMCID:: PMC10567853

Abstract Article PDF–14M

Select item 1056587617.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1051863118.

PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy

Bruktawit Maru, Alessandra Messikommer, Linhui Huang, Katja Seipel, Olivia Kovecses, Peter J.M. Valk, Alexandre P.A. Theocharides, Francois E. Mercier, Thomas Pabst, Maureen McKeague, Nathan W. Luedtke

Cell Rep Med. 2023 Sep 19; 4(9): 101191. Published online 2023 Sep 7. doi: 10.1016/j.xcrm.2023.101191

PMCID:: PMC10518631

Abstract Article PDF–5.3M

Select item 1051664819.

Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD⁺ levels

Anka Güldenpfennig, Ann-Katrin Hopp, Lukas Muskalla, Patrick Manetsch, Fabio Raith, Lars Hellweg, Cyril Dördelmann, Deena M Leslie Pedrioli, Kai Johnsson, Giulio Superti-Furga, Michael O Hottiger

Nucleic Acids Res. 2023 Sep 22; 51(17): 9248–9265. Published online 2023 Aug 17. doi: 10.1093/nar/gkad659

PMCID:: PMC10516648

Abstract Article PDF–1.8M

Select item 1048053520.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

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PMC Links for GEO Profiles (Select 83054762) (882)
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Obese women with polycystic ovary syndrome and obese, healthy women: skeletal mu...
Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle
Accession: GDS4133

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Esrrg estrogen-related receptor gamma [Mus musculus]
Esrrg estrogen-related receptor gamma [Mus musculus]
Gene ID:26381

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