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Select item 110887031.

Structural basis of human NOX5 activation

Chenxi Cui, Meiqin Jiang, Nikhil Jain, Sourav Das, Yu-Hua Lo, Ali A. Kermani, Tanadet Pipatpolkai, Ji Sun

Nat Commun. 2024; 15: 3994. Published online 2024 May 11. doi: 10.1038/s41467-024-48467-y

PMCID:: PMC11088703

Abstract Article PDF–2.1M

Select item 103001612.

Structure, regulation, and physiological functions of NADPH oxidase 5 (NOX5)

Jorge G. García, Eduardo Ansorena, Iñigo Izal, Guillermo Zalba, Carlos de Miguel, Fermín I. Milagro

J Physiol Biochem. 2023; 79(2): 383–395. Published online 2023 Mar 11. doi: 10.1007/s13105-023-00955-3

PMCID:: PMC10300161

Abstract Article PDF–1.3M

Select item 96258473.

NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients

Zhu Jiang, Linghe Wu, Britt van der Leeden, Albert C. van Rossum, Hans W.M. Niessen, Paul A.J. Krijnen

Int J Cardiol. 2023 Jan 1; 370: 454–462. Published online 2022 Nov 2. doi: 10.1016/j.ijcard.2022.10.172

PMCID:: PMC9625847

Abstract Article PDF–2.2M

Select item 93028924.

Nicotine promotes vascular calcification via intracellular Ca²⁺-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Ploingarm Petsophonsakul, Mathias Burgmaier, Brecht Willems, Sylvia Heeneman, Nadina Stadler, Felix Gremse, Sebastian Reith, Kathrin Burgmaier, Florian Kahles, Nikolaus Marx, Ehsan Natour, Elham Bidar, Michael Jacobs, Barend Mees, Chris Reutelingsperger, Malgorzata Furmanik, Leon Schurgers

Cardiovasc Res. 2022 Jun; 118(9): 2196–2210. Published online 2021 Jul 17. doi: 10.1093/cvr/cvab244

PMCID:: PMC9302892

Abstract Article PDF–1.4M

Select item 83296965.

NOX5 mediates the crosstalk between tumor cells and cancer‐associated fibroblasts via regulating cytokine network

Jie Chen, Yan Wang, Weimin Zhang, Di Zhao, Lingyuan Zhang, Jing Zhang, Jiawen Fan, Qimin Zhan

Clin Transl Med. 2021 Aug; 11(8): e472. Published online 2021 Aug 3. doi: 10.1002/ctm2.472

PMCID:: PMC8329696

Abstract Article PDF–9.3M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80086227.

NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease

Jing Wang, Jun Xiao, Xinyao Meng, Xufeng Chu, Di Di Zhuansun, Bo Xiong, Jiexiong Feng

BMC Pediatr. 2021; 21: 153. Published online 2021 Mar 30. doi: 10.1186/s12887-021-02611-5

PMCID:: PMC8008622

Abstract Article PDF–2.6M

Select item 77355338.

The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines

S. Carnesecchi, A.-L. Rougemont, J.H. Doroshow, M. Nagy, S. Mouche, F. Gumy-Pause, I. Szanto

Free Radic Biol Med. Author manuscript; available in PMC 2020 Dec 14.

Published in final edited form as: Free Radic Biol Med. 2015 Jul; 84: 22–29. Published online 2015 Mar 19. doi: 10.1016/j.freeradbiomed.2015.02.027

PMCID:: PMC7735533

Abstract Article PDF–1.6M

Select item 74269619.

Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells

Jie Chen, Yan Wang, Weimin Zhang, Di Zhao, Lingyuan Zhang, Jiawen Fan, Jinting Li, Qimin Zhan

Signal Transduct Target Ther. 2020; 5: 139. Published online 2020 Aug 14. doi: 10.1038/s41392-020-0193-z

PMCID:: PMC7426961

Abstract Article PDF–6.2M

Select item 731744910.

On the mechanism of calcium‐dependent activation of NADPH oxidase 5 (NOX5)

Elisa Millana Fañanás, Sofia Todesca, Alessandro Sicorello, Laura Masino, Petr Pompach, Francesca Magnani, Annalisa Pastore, Andrea Mattevi

FEBS J. 2020 Jun; 287(12): 2486–2503. Published online 2019 Dec 20. doi: 10.1111/febs.15160

PMCID:: PMC7317449

Abstract Article PDF–6.3M

Select item 714041811.

Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells

Javier Marqués, Adriana Cortés, Álvaro Pejenaute, Eduardo Ansorena, Gloria Abizanda, Felipe Prósper, Juan José Martínez-Irujo, Carlos de Miguel, Guillermo Zalba

Cells. 2020 Mar; 9(3): 637. Published online 2020 Mar 6. doi: 10.3390/cells9030637

PMCID:: PMC7140418

Abstract Article PDF–1.6M

Select item 702076412.

Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells

Yingxin Li, Yarong Li, Shouhao Zheng

Med Sci Monit. 2020; 26: e919399-1–e919399-11. Prepublished online 2020 Jan 21. Published online 2020 Feb 3. doi: 10.12659/MSM.919399

PMCID:: PMC7020764

Abstract Article PDF–2.1M

Select item 674514313.

Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis

Mihaela-Loredana Vlad, Simona-Adriana Manea, Alexandra-Gela Lazar, Monica Raicu, Horia Muresian, Maya Simionescu, Adrian Manea

Oxid Med Cell Longev. 2019; 2019: 3201062. Published online 2019 Sep 2. doi: 10.1155/2019/3201062

PMCID:: PMC6745143

Abstract Article PDF–6.3M

Select item 651928414.

NOX5: Molecular biology and pathophysiology

Rhian M. Touyz, Aikaterini Anagnostopoulou, Francisco Rios, Augusto C. Montezano, Livia L. Camargo

Exp Physiol. 2019 May 1; 104(5): 605–616. Published online 2019 Mar 18. doi: 10.1113/EP086204

PMCID:: PMC6519284

Abstract Article PDF–724K

Select item 635460115.

Vascular Biology of Superoxide-Generating NADPH Oxidase 5—Implications in Hypertension and Cardiovascular Disease

Rhian M. Touyz, Aikaterini Anagnostopoulou, Livia L. Camargo, Francisco J. Rios, Augusto C. Montezano

Antioxid Redox Signal. 2019 Mar 1; 30(7): 1027–1040. Published online 2019 Jan 21. doi: 10.1089/ars.2018.7583

PMCID:: PMC6354601

Abstract Article PDF–1.0M

Select item 622054416.

NADPH Oxidase 5 Is a Pro‐Contractile Nox Isoform and a Point of Cross‐Talk for Calcium and Redox Signaling‐Implications in Vascular Function

Augusto C. Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J. Rios, Adam P. Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P. Gandara, Rheure Alves‐Lopes, Karla B. Neves, Maria Dulak‐Lis, Chet E. Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy, Rhian M. Touyz

J Am Heart Assoc. 2018 Jun 19; 7(12): e009388. Published online 2018 Jun 15. doi: 10.1161/JAHA.118.009388

PMCID:: PMC6220544

Abstract Article PDF–1.8M

Select item 567580917.

NADPH oxidase 5 (NOX5)—induced reactive oxygen signaling modulates normoxic HIF‐1α and p27^Kip1 expression in malignant melanoma and other human tumors

Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L. Meitzler, Hala R. Makhlouf, Diana C. Haines, Donna Butcher, Dave S. Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K. Roy, James H. Doroshow

Mol Carcinog. 2017 Dec; 56(12): 2643–2662. Published online 2017 Aug 30. doi: 10.1002/mc.22708

PMCID:: PMC5675809

Abstract Article PDF–9.2M

Select item 553161118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366