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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108368062.

Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains

Hye Sun Kuehn, Inga S. Sakovich, Julie E. Niemela, Agustin A. Gil Silva, Jennifer L. Stoddard, Ekaterina A. Polyakova, Ana Esteve Sole, Svetlana N. Aleshkevich, Tatjana A. Uglova, Mikhail V. Belevtsev, Vladislav R. Vertelko, Tatsiana V. Shman, Aleksandra N. Kupchinskaya, Jolan E. Walter, Thomas A. Fleisher, Luigi D. Notarangelo, Xiao P. Peng, Ottavia M. Delmonte, Svetlana O. Sharapova, Sergio D. Rosenzweig

J Clin Invest. 2024 Feb 1; 134(3): e172573. Published online 2024 Feb 1. doi: 10.1172/JCI172573

PMCID:: PMC10836806

Abstract Article PDF–2.6M

Select item 108296923.

Genetic variations in IKZF3, LET7‐a2, and CDKN2B‐AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations

Alireza Paniri, Mohammad Mahdi Hosseini, Sadegh Fattahi, Galia Amiribozorgi, Mohsen Asouri, Mansooreh Maadi, Nima Motamed, Farhad Zamani, Haleh Akhavan‐Niaki

J Clin Lab Anal. 2024 Jan; 38(1-2): e24999. Published online 2024 Jan 9. doi: 10.1002/jcla.24999

PMCID:: PMC10829692

Abstract Article PDF–464K

Select item 100192424.

IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis

Hongxiang Li, Mengmeng Ye, Zeyang Hu, Haoxuan Lu, Dawei Zheng, Mi Wu, Ting Ge, Shuguang Xu, Zhen Ge, Shuoni Zhang, Guodong Xu, Hang Chen

Medicine (Baltimore) 2023 Mar 17; 102(11): e33124. Published online 2023 Mar 17. doi: 10.1097/MD.0000000000033124

PMCID:: PMC10019242

Abstract Article PDF–3.7M

Select item 98491415.

A proteome-scale map of the SARS-CoV-2–human contactome

Dae-Kyum Kim, Benjamin Weller, Chung-Wen Lin, Dayag Sheykhkarimli, Jennifer J. Knapp, Guillaume Dugied, Andreas Zanzoni, Carles Pons, Marie J. Tofaute, Sibusiso B. Maseko, Kerstin Spirohn, Florent Laval, Luke Lambourne, Nishka Kishore, Ashyad Rayhan, Mayra Sauer, Veronika Young, Hridi Halder, Nora Marín-de la Rosa, Oxana Pogoutse, Alexandra Strobel, Patrick Schwehn, Roujia Li, Simin T. Rothballer, Melina Altmann, Patricia Cassonnet, Atina G. Coté, Lena Elorduy Vergara, Isaiah Hazelwood, Betty B. Liu, Maria Nguyen, Ramakrishnan Pandiarajan, Bushra Dohai, Patricia A. Rodriguez Coloma, Juline Poirson, Paolo Giuliana, Luc Willems, Mikko Taipale, Yves Jacob, Tong Hao, David E. Hill, Christine Brun, Jean-Claude Twizere, Daniel Krappmann, Matthias Heinig, Claudia Falter, Patrick Aloy, Caroline Demeret, Marc Vidal, Michael A. Calderwood, Frederick P. Roth, Pascal Falter-Braun

Nat Biotechnol. 2023; 41(1): 140–149. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01475-z

PMCID:: PMC9849141

Abstract Article PDF–7.1M

Select item 96629456.

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

Patrick R. Hagner, Hsiling Chiu, Vivek S. Chopra, Martino Colombo, Nisha Patel, Maria Ortiz Estevez, Michelle F. Waldman, Remco Loos, Fadi Towfic, Anita K. Gandhi

Clin Cancer Res. 2022 Aug 2; 28(15): 3367–3377. Published online 2022 May 18. doi: 10.1158/1078-0432.CCR-21-3347

PMCID:: PMC9662945

Abstract Article PDF–1.6M

Select item 90142637.

AIOLOS Variants Causing Immunodeficiency in Human and Mice

Motoi Yamashita, Tomohiro Morio

Front Immunol. 2022; 13: 866582. Published online 2022 Apr 4. doi: 10.3389/fimmu.2022.866582

PMCID:: PMC9014263

Abstract Article PDF–3.1M

Select item 89589608.

A Variant in Human AIOLOS Impairs Adaptive Immunity by Interfering with IKAROS

Motoi Yamashita, Hye Sun Kuehn, Kazuki Okuyama, Satoshi Okada, Yuzaburo Inoue, Noriko Mitsuiki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Masahiro Takeuchi, Naoki Shimojo, Miyuki Tsumura, Aditya K. Padhi, Kam Y. J. Zhang, Bertrand Boisson, Jean-Laurent Casanova, Osamu Ohara, Sergio D. Rosenzweig, Ichiro Taniuchi, Tomohiro Morio

Nat Immunol. Author manuscript; available in PMC 2022 Mar 28.

Published in final edited form as: Nat Immunol. 2021 Jul; 22(7): 893–903. Published online 2021 Jun 21. doi: 10.1038/s41590-021-00951-z

PMCID:: PMC8958960

Abstract Article PDF–4.7M

Select item 88288959.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 854891410.

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients

Hye Sun Kuehn, Jingjie Chang, Motoi Yamashita, Julie E. Niemela, Chengcheng Zou, Kazuki Okuyama, Junji Harada, Jennifer L. Stoddard, Cristiane J. Nunes-Santos, Brigette Boast, Ryan M. Baxter, Elena W.Y. Hsieh, Mary Garofalo, Thomas A. Fleisher, Tomohiro Morio, Ichiro Taniuchi, Cullen M. Dutmer, Sergio D. Rosenzweig

J Exp Med. 2021 Dec 6; 218(12): e20211118. Published online 2021 Oct 25. doi: 10.1084/jem.20211118

PMCID:: PMC8548914

Abstract Article PDF–7.5M

Select item 854257411.

Aiolos regulates eosinophil migration into tissues

Jennifer M. Felton, Carine Bouffi, Justin T. Schwartz, Kaila L. Schollaert, Astha Malik, Sushmitha Vallabh, Benjamin Wronowski, Adam Z. Magier, Li Merlin, Artem Barski, Matthew T. Weirauch, Patricia C. Fulkerson, Marc E. Rothenberg

Mucosal Immunol. Author manuscript; available in PMC 2022 Feb 2.

Published in final edited form as: Mucosal Immunol. 2021 Nov; 14(6): 1271–1281. Published online 2021 Aug 2. doi: 10.1038/s41385-021-00416-4

PMCID:: PMC8542574

Abstract Article PDF–1.8M

Select item 852870412.

Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity

Jinxin Qiu, Jingjing Zhang, Yan Ji, Hanxiao Sun, Zhitao Gu, Qiangling Sun, Meizhu Bai, Jue Gong, Jupei Tang, Yunpeng Zhang, Shiyang Li, Zhen Shao, Jinsong Li, Huiming Sheng, Lei Shen, Ju Qiu

Mucosal Immunol. 2021; 14(6): 1306–1322. Published online 2021 Aug 4. doi: 10.1038/s41385-021-00431-5

PMCID:: PMC8528704

Abstract Article PDF–5.8M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 803454614.

A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

Gregory Lazarian, Shanye Yin, Elisa ten Hacken, Tomasz Sewastianik, Mohamed Uduman, Alba Font-Tello, Satyen H. Gohil, Shuqiang Li, Ekaterina Kim, Heather Joyal, Leah Billington, Elizabeth Witten, Mei Zheng, Teddy Huang, Mariano Severgnini, Valerie Lefebvre, Laura Z. Rassenti, Catherine Gutierrez, Katia Georgopoulos, Christopher J. Ott, Lili Wang, Thomas J. Kipps, Jan A. Burger, Kenneth J. Livak, Donna S Neuberg, Fanny Baran-Marszak, Florence Cymbalista, Ruben D. Carrasco, Catherine J. Wu

Cancer Cell. Author manuscript; available in PMC 2022 Mar 8.

Published in final edited form as: Cancer Cell. 2021 Mar 8; 39(3): 380–393.e8. doi: 10.1016/j.ccell.2021.02.003

PMCID:: PMC8034546

Abstract Article PDF–3.0M

Select item 786524515.

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them

Marco Cippitelli, Helena Stabile, Andrea Kosta, Sara Petillo, Angela Gismondi, Angela Santoni, Cinzia Fionda

Int J Mol Sci. 2021 Feb; 22(3): 1103. Published online 2021 Jan 22. doi: 10.3390/ijms22031103

PMCID:: PMC7865245

Abstract Article PDF–2.2M

Select item 766494316.

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus

Timothy J. Vyse, Deborah S. Cunninghame Graham

Int J Mol Sci. 2020 Nov; 21(21): 8383. Published online 2020 Nov 9. doi: 10.3390/ijms21218383

PMCID:: PMC7664943

Abstract Article PDF–4.5M

Select item 719351017.

IKZF1/3 and CRL4^CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma

Santiago Barrio, Umair Munawar, Yuan Xiao Zhu, Nicola Giesen, Chang-Xin Shi, Matteo Da Viá, Ricardo Sanchez, Laura Bruins, Theresa Demler, Nicole Müller, Larissa Haertle, Andoni Garitano, Torsten Steinbrunn, Sophia Danhof, Isabel Cuenca, Clara Barrio-Garcia, Esteban Braggio, Andreas Rosenwald, Joaquin Martinez-Lopez, Leo Rasche, Marc S. Raab, A. Keith Stewart, Hermann Einsele, Thorsten Stühmer, K. Martin Kortüm

Haematologica. 2020 May; 105(5): e237–e241. doi: 10.3324/haematol.2019.217943

PMCID:: PMC7193510

Article PDF–1.4M

Select item 716998318.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 674264619.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 668753420.

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

Nan Zhou, Alvaro Gutierrez-Uzquiza, Xiang Yu Zheng, Renxu Chang, Dan T. Vogl, Alfred L. Garfall, Luca Bernabei, Anita Saraf, Laurence Florens, Michael P. Washburn, Anuradha Illendula, John H. Bushweller, Luca Busino

Leukemia. 2019; 33(8): 2006–2021. Published online 2019 Feb 13. doi: 10.1038/s41375-019-0403-2