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Select item 108508181.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 83529642.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699834.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 64200975.

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids

Kyosuke Nakamura, Giulia Saredi, Jordan R. Becker, Benjamin M. Foster, Nhuong V. Nguyen, Tracey Beyer, Laura C. Cesa, Peter A. Faull, Saulius Lukauskas, Thomas Frimurer, J. Ross Chapman, Till Bartke, Anja Groth

Nat Cell Biol. Author manuscript; available in PMC 2019 Aug 25.

Published in final edited form as: Nat Cell Biol. 2019 Mar; 21(3): 311–318. Published online 2019 Feb 25. doi: 10.1038/s41556-019-0282-9

PMCID:: PMC6420097

Article PDF–1.7M

Select item 58567756.

SUMO targets the APC/C to regulate transition from metaphase to anaphase

Karolin Eifler, Sabine A. G. Cuijpers, Edwin Willemstein, Jonne A. Raaijmakers, Dris El Atmioui, Huib Ovaa, René H. Medema, Alfred C. O. Vertegaal

Nat Commun. 2018; 9: 1119. Published online 2018 Mar 16. doi: 10.1038/s41467-018-03486-4

PMCID:: PMC5856775

Abstract Article PDF–1.8M

Select item 56698147.

Assembly and Function of Heterotypic Ubiquitin Chains in Cell Cycle and Protein Quality Control

Richard G. Yau, Kerstin Doerner, Erick R. Castellanos, Diane L. Haakonsen, Achim Werner, Nan Wang, X. William Yang, Nadia Martinez-Martin, Marissa L. Matsumoto, Vishva M. Dixit, Michael Rape

Cell. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Cell. 2017 Nov 2; 171(4): 918–933.e20. Published online 2017 Oct 12. doi: 10.1016/j.cell.2017.09.040

PMCID:: PMC5669814

Abstract Article PDF–3.1M

Select item 50358758.

WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity

Qiuhong Li, Leifu Chang, Shintaro Aibara, Jing Yang, Ziguo Zhang, David Barford

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): 10547–10552. Published online 2016 Sep 6. doi: 10.1073/pnas.1607147113

PMCID:: PMC5035875

Abstract Article PDF–1.2M

Select item 48828679.

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor

Sarah Daakour, Leon Juvenal Hajingabo, Despoina Kerselidou, Aurelie Devresse, Richard Kettmann, Nicolas Simonis, Franck Dequiedt, Jean-Claude Twizere

BMC Cancer. 2016; 16: 335. Published online 2016 May 26. doi: 10.1186/s12885-016-2374-2

PMCID:: PMC4882867

Abstract Article PDF–1.8M

Select item 487866910.

Molecular mechanism of APC/C activation by mitotic phosphorylation

Suyang Zhang, Leifu Chang, Claudio Alfieri, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel, David Barford

Nature. Author manuscript; available in PMC 2016 Oct 27.

Published in final edited form as: Nature. 2016 May 12; 533(7602): 260–264. Published online 2016 Apr 27. doi: 10.1038/nature17973

PMCID:: PMC4878669

Abstract Article PDF–5.3M

Select item 464794111.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 460804812.

Atomic structure of the APC/C and its mechanism of protein ubiquitination

Leifu Chang, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin, David Barford

Nature. Author manuscript; available in PMC 2015 Dec 25.

Published in final edited form as: Nature. 2015 Jun 25; 522(7557): 450–454. Published online 2015 Jun 15. doi: 10.1038/nature14471

PMCID:: PMC4608048

Abstract Article PDF–5.4M

Select item 445666013.

Molecular architecture and mechanism of the anaphase-promoting complex

Lei-Fu Chang, Ziguo Zhang, Jing Yang, Stephen H. McLaughlin, David Barford

Nature. Author manuscript; available in PMC 2015 Jun 5.

Published in final edited form as: Nature. 2014 Sep 18; 513(7518): 388–393. Published online 2014 Jul 20. doi: 10.1038/nature13543

PMCID:: PMC4456660

Abstract Article PDF–4.7M

Select item 444436914.

Structure of an APC3-APC16 complex: Insights into assembly of the Anaphase Promoting Complex/Cyclosome

Masaya Yamaguchi, Shanshan Yu, Renping Qiao, Florian Weissmann, Darcie J. Miller, Ryan VanderLinden, Nicholas G. Brown, Jeremiah J. Frye, Jan-Michael Peters, Brenda A. Schulman

J Mol Biol. Author manuscript; available in PMC 2016 Apr 24.

Published in final edited form as: J Mol Biol. 2015 Apr 24; 427(8): 1748–1764. Published online 2014 Dec 6. doi: 10.1016/j.jmb.2014.11.020

PMCID:: PMC4444369

Abstract Article PDF–2.5M

Select item 388259115.

Transcriptional Intermediary Factor 1? binds to the Anaphase-Promoting Complex/Cyclosome and promotes mitosis

Garry G. Sedgwick, Kelly Townsend, Ashley Martin, Neil J. Shimwell, Roger J. A. Grand, Grant S. Stewart, Jakob Nilsson, Andrew S. Turnell

Oncogene. Author manuscript; available in PMC 2014 Mar 26.

Published in final edited form as: Oncogene. 2013 Sep 26; 32(39): 10.1038/onc.2012.501. Published online 2012 Nov 19. doi: 10.1038/onc.2012.501

PMCID:: PMC3882591

Abstract Article PDF–4.1M

Select item 349806216.

APC15 mediates CDC20 auto-ubiquitylation by APC/C^MCC and MCC disassembly

Kristina Uzunova, Billy T. Dye, Hannelore Schutz, Rene Ladurner, Georg Petzold, Yusuke Toyoda, Marc A. Jarvis, Nicholas G. Brown, Ina Poser, Maria Novatchkova, Karl Mechtler, Anthony A. Hyman, Holger Stark, Brenda A. Schulman, Jan-Michael Peters

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Struct Mol Biol. 2012 Nov; 19(11): 1116–1123. Published online 2012 Sep 24. doi: 10.1038/nsmb.2412