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Select item 112755061.

The Evolution of Genetic Variability at the LRRK2 Locus

Dylan T. Guenther, Jordan Follett, Rim Amouri, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer

Genes (Basel) 2024 Jul; 15(7): 878. Published online 2024 Jul 3. doi: 10.3390/genes15070878

PMCID:: PMC11275506

Abstract Article PDF–1.0M

Select item 111464322.

Genetic analysis and natural history of Parkinson’s disease due to the LRRK2 G2019S variant

Matthew J Kmiecik, Steven Micheletti, Daniella Coker, Karl Heilbron, Jingchunzi Shi, Keaton Stagaman, Teresa Filshtein Sonmez, Pierre Fontanillas, Suyash Shringarpure, Madeleine Wetzel, Helen M Rowbotham, Paul Cannon, Janie F Shelton, David A Hinds, Joyce Y Tung, 23andMe Research Team , Michael V Holmes, Stella Aslibekyan, Lucy Norcliffe-Kaufmann

Brain. 2024 Jun; 147(6): 1996–2008. Published online 2024 May 28. doi: 10.1093/brain/awae073

PMCID:: PMC11146432

Abstract Article PDF–855K

Select item 111132133.

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

José M. Bravo-San Pedro, Mireia Niso-Santano, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Ana Aiastui-Pujana, Ana Gorostidi, Vicente Climent, Rakel López de Maturana, Rosario Sanchez-Pernaute, Adolfo López de Munain, José M. Fuentes, Rosa A. González-Polo

Cell Mol Life Sci. 2013 Jan; 70(1): 121–136. Published online 2012 Jul 8. doi: 10.1007/s00018-012-1061-y

PMCID:: PMC11113213

Abstract Article PDF–1.0M

Select item 110963884.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson’s disease

Ping Fang, Lewis W. Yu, Hannah Espey, Gulistan Agirman, Sabeen A. Kazmi, Kai Li, Yongning Deng, Jamie Lee, Haley Hrncir, Arlene Romero-Lopez, Arthur P. Arnold, Elaine Y. Hsiao

Commun Biol. 2024; 7: 570. Published online 2024 May 15. doi: 10.1038/s42003-024-06256-9

PMCID:: PMC11096388

Abstract Article PDF–4.6M

Select item 110154865.

Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson’s disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls

Julia G. Mannheim, Jessie Fanglu Fu, Tilman Wegener, Ivan S. Klyuzhin, Nasim Vafai, Elham Shahinfard, Jessamyn McKenzie, Audrey Strongosky, Zbigniew K. Wszolek, A. Jon Stoessl, Vesna Sossi

Neuroimage Clin. 2024; 42: 103600. Published online 2024 Apr 1. doi: 10.1016/j.nicl.2024.103600

PMCID:: PMC11015486

Abstract Article PDF–2.7M

Select item 109591206.

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

Dan Dou, Jayne Aiken, Erika L.F. Holzbaur

J Cell Biol. 2024 Jun 3; 223(6): e202307092. Published online 2024 Mar 21. doi: 10.1083/jcb.202307092

PMCID:: PMC10959120

Abstract Article PDF–5.4M

Select item 108748597.

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons

Adamantios Mamais, Anwesha Sanyal, Austin Fajfer, Catherine G. Zykoski, Michael Guldin, Alexis Riley-DiPaolo, Nitya Subrahmanian, Whitney Gibbs, Steven Lin, Matthew J. LaVoie

Stem Cell Reports. 2024 Feb 13; 19(2): 163–173. Published online 2024 Feb 1. doi: 10.1016/j.stemcr.2024.01.001

PMCID:: PMC10874859

Abstract Article PDF–5.3M

Select item 108747008.

VPS35 and retromer dysfunction in Parkinson's disease

Jordan Rowlands, Darren J. Moore

Philos Trans R Soc Lond B Biol Sci. April 8, 2024; 379(1899): 20220384. Published online February 19, 2024. doi: 10.1098/rstb.2022.0384

PMCID:: PMC10874700

Abstract Article PDF–578K

Select item 108049199.

Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study

Xiaohui Sun, Kaixin Dou, Li Xue, Yijie Xie, Yong Yang, Anmu Xie

Clin Transl Sci. 2024 Jan; 17(1): e13720. Published online 2024 Jan 23. doi: 10.1111/cts.13720

PMCID:: PMC10804919

Abstract Article PDF–3.5M

Select item 1079155810.

The V-ATPase–ATG16L1 axis recruits LRRK2 to facilitate the lysosomal stress response

Tomoya Eguchi, Maria Sakurai, Yingxue Wang, Chieko Saito, Gen Yoshii, Thomas Wileman, Noboru Mizushima, Tomoki Kuwahara, Takeshi Iwatsubo

J Cell Biol. 2024 Mar 4; 223(3): e202302067. Published online 2024 Jan 16. doi: 10.1083/jcb.202302067

PMCID:: PMC10791558

Abstract Article PDF–5.8M

Select item 1071937711.

Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson’s disease related transcriptional profile and function

Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm

Sci Rep. 2023; 13: 22118. Published online 2023 Dec 13. doi: 10.1038/s41598-023-49294-9

PMCID:: PMC10719377

Abstract Article PDF–3.9M

Select item 1070888912.

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Marcus Y Chin, Audrey Cheuk-Nga Ho, Rajarshi Ghosh, Dara E Leto, David Joy, Meredith EK Calvert, Joseph W Lewcock, Gilbert Di Paolo, Robert G Thorne, Zachary K Sweeney, Anastasia G Henry

eLife. 2023; 12: e87255. Published online 2023 Oct 24. doi: 10.7554/eLife.87255

PMCID:: PMC10708889

Abstract Article PDF–1.9M

Select item 1062291113.

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

Wondwossen M. Yeshaw, Ayan Adhikari, Claire Y. Chiang, Herschel S. Dhekne, Paulina S. Wawro, Suzanne R. Pfeffer

Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44): e2315171120. Published online 2023 Oct 27. doi: 10.1073/pnas.2315171120

PMCID:: PMC10622911

Abstract Article PDF–6.7M

Select item 1061437814.

LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity

Yuichi Mazaki, Haruka Handa, Yoshizuki Fumoto, Takahiro Horinouchi, Yasuhito Onodera

Cell Commun Signal. 2023; 21: 300. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01305-y

PMCID:: PMC10614378

Abstract Article PDF–1.3M

Select item 1057524515.

Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation

Eden Shkury, Shani Danziger-Schragenheim, Zoya Katzir, Yael Ezra, Nir Giladi, Anat Mirelman, Inbal Maidan

Sensors (Basel) 2023 Oct; 23(19): 8266. Published online 2023 Oct 6. doi: 10.3390/s23198266

PMCID:: PMC10575245

Abstract Article PDF–2.0M

Select item 1055190116.

Endogenous Rab38 regulates LRRK2’s membrane recruitment and substrate Rab phosphorylation in melanocytes

Alexandra Unapanta, Farbod Shavarebi, Jacob Porath, Yiyi Shen, Carson Balen, Albert Nguyen, Josh Tseng, Weng Si Leong, Michelle Liu, Pawel Lis, Santiago M. Di Pietro, Annie Hiniker

J Biol Chem. 2023 Oct; 299(10): 105192. Published online 2023 Aug 23. doi: 10.1016/j.jbc.2023.105192

PMCID:: PMC10551901

Abstract Article PDF–4.1M

Select item 1052623817.

The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson’s Disease

Alexandra Albus, Yannick Kronimus, Monika Burg-Roderfeld, Hendrik van der Wurp, Dieter Willbold, Tamar Ziehm, Richard Dodel, Jean Alexander Ross

Biomolecules. 2023 Sep; 13(9): 1303. Published online 2023 Aug 25. doi: 10.3390/biom13091303

PMCID:: PMC10526238

Abstract Article PDF–571K

Select item 1052485718.

Patterns of TDP-43 Deposition in Brains with LRRK2 G2019S Mutations

Julian Agin-Liebes, Richard A. Hickman, Jean Paul Vonsattel, Phyllis L. Faust, Xena Flowers, Irina Utkina Sosunova, Joel Ntiri, Richard Mayeux, Matthew Surface, Karen Marder, Stanley Fahn, Serge Przedborski, Roy N. Alcalay

Mov Disord. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Mov Disord. 2023 Aug; 38(8): 1541–1545. Published online 2023 May 23. doi: 10.1002/mds.29449

PMCID:: PMC10524857

Abstract Article PDF–355K

Select item 1050869519.

Leucine-rich repeat kinase 2 at a glance

Christiane Zhu, Susanne Herbst, Patrick A. Lewis

J Cell Sci. 2023 Sep 1; 136(17): jcs259724. Published online 2023 Sep 12. doi: 10.1242/jcs.259724

PMCID:: PMC10508695

Abstract Article

Select item 1047042020.

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen

Redox Biol. 2023 Oct; 66: 102860. Published online 2023 Aug 22. doi: 10.1016/j.redox.2023.102860